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Anti-Atopic Effects of Mixed Extracts from Date Plum, Persimmon, and Mulberry Leaves
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 Title & Authors
Anti-Atopic Effects of Mixed Extracts from Date Plum, Persimmon, and Mulberry Leaves
Cho, Byoung Ok; Yin, Hong Hua; Shin, Jae Young; Fang, Chong Zhou; Chang, Che Denis; Jang, Seon Il;
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The present study investigated the anti-atopic effects of mixed extracts from date plum, persimmon, and mulberry leaves (DPME) on atopic dermatitis (AD)-like skin lesions in hairless mice. The in vivo results demonstrated that DPME treatment significantly reduced the dermatitis clinical score and epidermal thickness in AD-like skin lesions. Histological analyses showed that DPME treatment strongly inhibited dermal infiltration of inflammatory cells and activity of mast cells in AD-like skin lesions. DPME treatment inhibited production of serum IgE and interluekin (IL)-4 in hairless mice with AD. Moreover, DPME treatment significantly suppressed production of tumor necrosis factor and IL-6 cytokines in phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated HMC-1 human mast cells. In addition, DPME treatment reduced production of pro-inflammatory mediators (nitric oxide, prostaglandin E2, , and IL-6) in lipopolysaccharide-stimulated RAW 264.7 macrophages. Therefore, the results of this study indicate that the anti-atopic and anti-inflammatory effects of DPME may be involved in the regulation of inflammatory responses, suggesting that DPME may be used as an anti-atopic dermatitis material and natural anti-inflammatory ingredient.
date plum leaves;persimmon leaves;mulberry leaves;atopic dermatitis;inflammation;
 Cited by
Shaw TE, Currie GP, Koudelka CW, Simpson EL. 2011. Eczema prevalence in the United States: data from the 2003 National Survey of Children's Health. J Invest Dermatol 131: 67-73. crossref(new window)

Guttman-Yassky E, Nograles KE, Krueger JG. 2011. Contrasting pathogenesis of atopic dermatitis and psoriasis-part I: clinical and pathologic concepts. J Allergy Clin Immunol 127: 1110-1118. crossref(new window)

Jeon IH, Kang HJ, Kim SJ, Jeong SI, Lee HS, Jang SI. 2014. Antioxidant and antipruritic activities of ethyl acetate fraction from Diospyros lotus leaves. J Korean Soc Food Sci Nutr 43: 1635-1641. crossref(new window)

Boguniewicz M, Leung DY. 2010. Recent insights into atopic dermatitis and implications for management of infectious complications. J Allergy Clin Immunol 125: 4-13. crossref(new window)

Park KS, Kim KJ. 2010. Effects of atopic dermatitis induced materials on the expression of cytokine genes in human monocytes and mast cells. J Korean Orient Med Ophthalmol Otolaryngol Dermatol 23: 41-56.

Leung DY. 1999. Pathogenesis of atopic dermatitis. J Allergy Clin Immunol 104: S99-S108. crossref(new window)

Kim HS, Jung JI, Suh SB, Jung JA. 2013. Characteristics between IgE mediated and non-IgE mediated atopic dermatitis in children. Allergy Asthma Respir Dis 1: 339-343. crossref(new window)

Kang BK, Kim KBWR, Kim MJ, Bark SW, Park WM, Kim BR, Ahn NK, Choi YU, Bae NY, Park JH, Ahn DH. 2015. Anti-atopic activity of tuna heart ethanol extract. J Korean Soc Food Sci Nutr 44: 1-6. crossref(new window)

Kim SJ, Kim JA, Kim DH, Kwak SH, Yu KY, Jang SI, Kim SY, Jeong SI. 2015. Bio-assay guided isolation and identification of ${\alpha}$-glucosidase inhibitors from the leaves of Diospyros lotus. Kor J Pharmacogn 46: 105-108.

Said A, Hawas UW, Nofal SM, Rashed K, Huefner A. 2009. Pharmaco-chemical studies on the aqueous methanolic extract of Diospyros lotus leaves. Res J Phytochem 3: 1-12. crossref(new window)

Xie C, Xie Z, Xu X, Yang D. 2015. Persimmon (Diospyros kaki L.) leaves: a review on traditional uses, phytochemistry and pharmacological properties. J Ethnopharmacol 163: 229-240. crossref(new window)

Jeong SI, Cho JK, Mok JY, Kim SJ, Park JM, Jeon IH, Kim HS, Jang SI. 2010. Antioxidant activity of persimmon leaves during growth. Kor J Pharmacogn 41: 255-263.

Kim KA, Kang SW, Ahn HR, Song Y, Yang SJ, Jung SH. 2015. Leaves of persimmon (Diospyros kaki Thunb.) ameliorate N-methyl-N-nitrosourea (MNU)-induced retinal degeneration in mice. J Agric Food Chem 63: 7750-7759. crossref(new window)

El-Sayyad HIH, El-Sherbiny MA, Sobh MA, Abou-El-Naga AM, Ibrahim MAN, Mousa SA. 2011. Protective effects of Morus alba leaves extract on ocular functions of pups from diabetic and hypercholesterolemic mother rats. Int J Biol Sci 7: 715-728. crossref(new window)

Kim EJ, Kim GY, Kim YM, Choi KH, Jang SJ. 2009. Antiobesity effect of mulberry leaves extraction in obese rats high-fat diet. Korean J Orient Physiol Pathol 23: 831-836.

Kobayashi Y, Miyazawa M, Kamei A, Abe K, Kojima T. 2010. Ameliorative effects of mulberry (Morus alba L.) leaves on hyperlipidemia in rats fed a high-fat diet: induction of fatty acid oxidation, inhibition of lipogenesis, and suppression of oxidative stress. Biosci Biotechnol Biochem 74: 2385-2395. crossref(new window)

Lim HH, Lee SO, Kim SY, Yang SJ, Lim Y. 2013. Anti-inflammatory and antiobesity effects of mulberry leaf and fruit extract on high fat diet-induced obesity. Exp Biol Med (Maywood) 238: 1160-1169. crossref(new window)

Yang HJ, Park KW, Kim HS, Cho SM, Park KM. 2010. Effect of anti-atopic allergic reaction in response to oriental herb extracts. Korean J Food Sci Technol 42: 109-114.

Byun MW, Byun EH. 2015. Immunological synergistic effects of combined treatment with herbal preparation (Hemo- HIM) and red ginseng extracts. J Korean Soc Food Sci Nutr 44: 182-190. crossref(new window)

Kim DJ, Kim JM, Kim TH, Baek JM, Kim HS, Choe M. 2010. Effects of mixed extract from Lycium chinense, Cordyceps militaris, and Acanthopanax senticosus on glucoseregulating enzymes of HepG2 in hyperglycemic conditions. J Korean Soc Food Sci Nutr 39: 1257-1262. crossref(new window)

Kim HS, Jeon IH, Mok JY, Kang HJ, Shin JH, Park YK, Jeong SI, Jang SI. 2013. Anti-allergy and anti-pruritic effects of Diospyros lotus L. leaf extract. Kor J Pharmacogn 44: 60-69.

Cho JK, Jeon IH, Park JM, Kim HS, Jang SI. 2011. Inhibitory effect of persimmon leaf extract on development of atopic dermatitis-like skin lesions. J Korean Soc Appl Biol Chem 54: 653-657.

Kwon TO, Choi J, Lee HS, Cho BO, Yin HH, Jang SI. 2015. Anti-diabetic effects of Mori Folium extract on high-fat diet and streptozotocin-induced type II diabetes mellitus in mice. Kor J Herbol 30: 1-9.

Omata N, Tsukahara H, Ito S, Ohshima Y, Yasutomi M, Yamada A, Jiang M, Hiraoka M, Nambu M, Deguchi Y, Mayumi M. 2001. Increased oxidative stress in childhood atopic dermatitis. Life Sci 69: 223-228. crossref(new window)

Gonzalez-Rey E, Chorny A, Delgado M. 2007. Regulation of immune tolerance by anti-inflammatory neuropeptides. Nat Rev Immunol 7: 52-63. crossref(new window)

Theoharides TC, Alysandratos KD, Angelidou A, Delivanis DA, Sismanopoulos N, Zhang B, Asadi S, Vasiadi M, Weng Z, Miniati A, Kalogeromitros D. 2012. Mast cells and inflammation. Biochim Biophys Acta 1822: 21-33. crossref(new window)

Kim GD, Lee SE, Park YS, Shin DH, Park GG, Park CS. 2014. Immunosuppressive effects of fisetin against dinitrofluorobenzene- induced atopic dermatitis-like symptoms in NC/Nga mice. Food Chem Toxicol 66: 341-349. crossref(new window)

Tsuduki T, Kuriyama K, Nakagawa K, Miyazawa T. 2013. Tocotrienol (unsaturated vitamin E) suppresses degranulation of mast cells and reduces allergic dermatitis in mice. J Oleo Sci 62: 825-834. crossref(new window)

Kim H, Kim JR, Kang H, Choi J, Yang H, Lee P, Kim J, Lee KW. 2014. 7,8,4'-Trihydroxyisoflavone attenuates DNCBinduced atopic dermatitis-like symptoms in NC/Nga mice. PLoS One 9: e104938. crossref(new window)

Park BK, Park YC, Jung IC, Kim SH, Choi JJ, Do M, Kim SY, Jin M. 2015. Gamisasangja-tang suppresses pruritus and atopic skin inflammation in the NC/Nga murine model of atopic dermatitis. J Ethnopharmacol 165: 54-60. crossref(new window)

Yang G, An D, Lee MH, Lee K, Kim B, Khanita Suman C, Ham I, Choi HY. 2016. Effect of Acer tegmentosum bark on atopic dermatitis-like skin lesions in NC/Nga mice. J Ethnopharmacol 177: 53-60. crossref(new window)

Choi WS, Shin PG, Lee JH, Kim GD. 2012. The regulatory effect of veratric acid on NO production in LPS-stimulated RAW264.7 macrophage cells. Cell Immunol 280: 164-170. crossref(new window)

Wu Q, Li H, Qiu J, Feng H. 2014. Betulin protects mice from bacterial pneumonia and acute lung injury. Microb Pathog 75: 21-28. crossref(new window)

Uddin G, Rauf A, Siddiqui BS, Muhammad N, Khan A, Shah SU. 2014. Anti-nociceptive, anti-inflammatory and sedative activities of the extracts and chemical constituents of Diospyros lotus L.. Phytomedicine 21: 954-959. crossref(new window)

Kim HH, Kim DS, Kim SW, Lim SH, Kim DK, Shin TY, Kim SH. 2013. Inhibitory effects of Diospyros kaki in a model of allergic inflammation: role of cAMP, calcium and nuclear factor-${\kappa}B$. Int J Mol Med 32: 945-951. crossref(new window)

Lim HH, Yang SJ, Kim Y, Lee M, Lim Y. 2013. Combined treatment of mulberry leaf and fruit extract ameliorates obesity- related inflammation and oxidative stress in high fat diet-induced obese mice. J Med Food 16: 673-680. crossref(new window)

Tan WS, Arulselvan P, Karthivashan G, Fakurazi S. 2015. Moringa oleifera flower extract suppresses the activation of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 macrophages via NF-${\kappa}B$ pathway. Mediators Inflammation 2015: 720171.

Jung WY, Jeong JM. 2012. Change of antioxidative activity at different harvest time and improvement of atopic dermatitis effects for persimmon leaf extract. Kor J Herbol 27: 41-49. crossref(new window)

Park SM, Byun SH, Kim YW, Cho IJ, Kim SC. 2012. Inhibitory effect of Mori Folium ethanol extract on pro-inflammatory mediator in lipopolysaccharide-activated RAW 264.7 cells. Kor J Herbol 27: 31-38.

Lee SG, Jeong HJ, Lee EJ, Kim JB, Choi SW. 2011. Antioxidant and anti-inflammatory activities of ethanol extracts from medicinal herb mixtures. Korean J Food Sci Technol 43: 200-205. crossref(new window)

Kang CH, Kwak DY, So JS. 2013. Inhibition of nitric oxide production and hyaluronidase activities from the combined extracts of Platycodon grandiflorum, Astragalus membranaceus, and Schisandra chinensis. J Korean Soc Food Sci Nutr 42: 844-850. crossref(new window)

Kim DH, An BJ, Kim SG, Park TS, Park GH, Son JH. 2011. Anti-inflammatory effect of Ligularia fischeri, Solidago virga-aurea and Aruncus dioicus complex extracts in Raw 264.7 cells. J Life Sci 21: 678-683. crossref(new window)

Jang YA, Lee JT. 2014. Effects of mixture extract on allergic contact dermatitis and anti-inflammatory. Kor J Herbol 29: 55-60.