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Anti-Allergic Effect of 1,2,3,4,6-Penta-O-Galloyl-β-D-Glucose on RBL-2H3 Cells
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 Title & Authors
Anti-Allergic Effect of 1,2,3,4,6-Penta-O-Galloyl-β-D-Glucose on RBL-2H3 Cells
Kim, Yoon Hee; Choi, Ye Rang; Kim, Ji Young; Kwak, Sang Hee;
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 Abstract
1,2,3,4,6-Penta-O-galloyl--D-glucose (PGG) is a gallotannin isolated from various plants such as Galla Rhois. In a previous study, it was reported that PGG has anti-allergic effects by inhibiting interleukin (IL)-4 signaling in B cells. However, the effect of PGG on basophilic cells remains unclear. Therefore, the aim of this study was to investigate the inhibitory effect of PGG on mitogen and calcium ionophore-induced allergic responses. PGG had no effect on proliferation and cytotoxicity of RBL-2H3 cells. PGG significantly suppressed cell degranulation (histamine and ) as well as inflammatory cytokine production such as IL-4 and tumor necrosis factor-. The underlying mechanism of PGG on these anti-allergic actions was correlated with inhibition on translocation of nuclear factor- from the cytosol to nucleus. These data suggest that PGG is a potentially effective functional compound for prevention of allergic diseases.
 Keywords
PGG;gallotannin;anti-allergy;RBL-2H3 cell;
 Language
Korean
 Cited by
 References
1.
Patel BY, Volcheck GW. 2015. Food allergy: common causes, diagnosis, and treatment. Mayo Clin Proc 90: 1411-1419. crossref(new window)

2.
Thomsen SF. 2015. Epidemiology and natural history of atopic diseases. Eur Clin Respir J 2: 1-6.

3.
He S, Zhang H, Zeng X, Chen D, Yang P. 2013. Mast cells and basophils are essential for allergies: mechanisms of allergic inflammation and a proposed procedure for diagnosis. Acta Pharmacol Sin 34: 1270-1283. crossref(new window)

4.
Harvima IT, Levi-Schaffer F, Draber P, Friedman S, Polakovicova I, Gibbs BF, Blank U, Nilsson G, Maurer M. 2014. Molecular targets on mast cells and basophils for novel therapies. J Allergy Clin Immunol 134: 530-544. crossref(new window)

5.
Pevec B, Pevec MR, Markovic AS, Batista I. 2011. The high-affinity IgE-receptor signaling pathway in the treatment of allergies. Acta Med Croat 65: 425-434.

6.
Lyu JH, Lyu SA, Yoon HJ, Ko WS. 2008. Anti-allergic effect of Seungmagalgeun-tang through suppression of $NF-{\kappa}B$ and p38 mitogen-activated protein kinase activation in the RBL-2H3 cells. Korean J Orient Physiol Pathol 22: 1572-1578.

7.
Kim E, Ahn S, Lee DC. 2015. Inhibitory effect of Alpiniae officinarum Rhizoma extract on degranulation in RBL-2H3 cells. Korean J Plant Resour 28: 321-328. crossref(new window)

8.
Choi MY, Choi EJ, Lee E. 1999. Effect of Rhus chinensis gall extract on liver function, plasma lipid composition and antioxidant system in rats with high fat diet. J Korean Soc Food Sci Nutr 28: 632-637.

9.
Lee YS, Han OK, Bae MJ, Kim KJ, Shin SW, Lee SK, Park JH. 2003. Antimicrobial and anticancer effects of Galla Rhois on pathogens isolated from oral and KB human oral epidermoid carcinoma cells. Korean J Orient Physiol Pathol 17: 1427-1432.

10.
Cho HS, Kang S, Kim JH, Choi MJ, Yu HW, Park E, Chun HS. 2014. Antioxidant and antimicrobial activities of combined extracts of Galla rhois, Achyranthes japonica Nakai, Terminalia chebula Retz and Glycyrrhiza uralensis. Korean Soc Biotechnol Bioeng J 29: 29-35.

11.
Ata N, Oku T, Hattori M, Fujii H, Nakajima M, Saiki I. 1996. Inhibition by galloylglucose (GG6-10) of tumor invasion through extracellular matrix and gelatinase-mediated degradation of type IV collagens by metastatic tumor cells. Oncol Res 8: 503-511.

12.
Huh JE, Lee HJ, Song GY, Cha BC, Kim HS, Yoo DY, Ryu SY, Kim SH. 2002. Effect of 1,2,3,4,6-penta-O-galloyl-${\beta}$-D-glucose isolated from Galla Rhois on gap junctional intercellular communication and antiangiogenic activity. Korean J Orient Physiol Pathol 16: 452-457.

13.
Kwon OJ, Bae JS, Lee HY, Hwang JY, Lee EW, Ito H, Kim TH. 2013. Pancreatic lipase inhibitory gallotannins from Galla Rhois with inhibitory effects on adipocyte differentiation in 3T3-L1 cells. Molecules 18: 10629-10638. crossref(new window)

14.
Kim YH, Yoshimoto M, Nakayama K, Tanino S, Fujimura Y, Yamada K, Tachibana H. 2013. Tannic acid, a higher galloylated pentagalloylglucose, suppresses antigen-specific IgE production by inhibiting $\varepsilon$ germline transcription induced by STAT6 activation. FEBS Open Bio 3: 341-345. crossref(new window)

15.
Kim YH, Yang X, Yamashita S, Kumazoe M, Huang Y, Nakahara K, Won YS, Murata M, Lin IC, Tachibana H. 2015. 1,2,3,4,6-Penta-O-galloyl-${\beta}$-D-glucopyranose increases a population of T regulatory cells and inhibits IgE production in ovalbumin-sensitized mice. Int Immunopharmacol 26: 30-36. crossref(new window)

16.
Galli SJ, Nakae S, Tsai M. 2005. Mast cells in the development of adaptive immune responses. Nat Immunol 6: 135-142. crossref(new window)

17.
Song Z, Casolara V, Chen R, Georas SN, Monos D, Ono SJ. 1996. Polymorphic nucleotides within the human IL-4 promoter that mediate overexpression of the gene. J Immunol 156: 424-429.

18.
van Beek AA, Knol EF, de Vos P, Smelt MJ, Savelkoul HFJ, van Neerven RJJ. 2013. Recent developments in basophil research: do basophils initiate and perpetuate type 2 T-helper cell responses?. Int Arch Allergy Immunol 160: 7-17. crossref(new window)

19.
Kim MA, Son HU, Nam DY, Cha YS, Shin YK, Choi YH, Lee SH. 2012. Inhibitory effect of Angelica keiskei extract in an atopic dermatitis animal model. Korean J Food Preserv 19: 792-798. crossref(new window)

20.
Lee MY, Seo CS, Lee JA, Lee NH, Kim JH, Ha H, Zheng MS, Son JK, Shin HK. 2011. Anti-asthmatic effects of Angelica dahurica against ovalbumin-induced airway inflammation via upregulation of heme oxygenase-1. Food Chem Toxicol 49: 829-837. crossref(new window)

21.
Coward WR, Okayama Y, Sagara H, Wilson SJ, Holgate ST, Church MK. 2002. $NF-{\kappa}B$ and $TNF-{\alpha}$: a positive autocrine loop in human lung mast cells?. J Immunol 169: 5287-5293. crossref(new window)

22.
Kim W. 2010. Experimental study about pathway of Aconiti Ciliare Tuber on allergic reaction of inflammation. Korean J Orient Med 16: 155-166.