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Sorghum Extract Lowers Lymphatic Absorption of Trans Fat and Cholesterol in Rats
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 Title & Authors
Sorghum Extract Lowers Lymphatic Absorption of Trans Fat and Cholesterol in Rats
Kim, Juyeon; Noh, Sang Kyu; Woo, Koan-Sik; Seo, Myung-Chul;
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Excessive intake of trans fats is a risk factor for cardiovascular diseases. Previously, we showed that green tea extract lowers intestinal absorption of cholesterol and elaidic acid in rats. This study was conducted to investigate a possible role for sorghum extract on lymphatic absorption of trans fat and cholesterol in rats. Adult male rats with lymph cannulae were infused at a rate of 3.0 mL/h for 8 h via a duodenal catheter with a lipid emulsion containing of trielaidin, of trilinoelaidin, of triolein, cholesterol labeled with (), of cholesterol, and of Na-taurocholate without or with 100.0 mg of sorghum extract in phosphate-buffered saline buffer (pH 6.4). Lymph was collected hourly for 8 h. No significant difference was noted in lymph flow. However, the lymphatic absorption of elaidic acid and linoelaidic acid for 8 h was significantly lower in rats infused with sorghum extract than in those infused with no sorghum extract. Further, lymphatic absorption of was reduced by sorghum extract, which was observed previously. These data indicate that sorghum extract has an inhibitory effect on the intestinal absorption of trans fat and cholesterol. The mechanism(s) by which sorghum extract lowers intestinal absorption of trans fat warrants further study.
cholesterol;intestinal absorption;rats;sorghum extract;trans fat;
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