JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Changes in Platycoside Components and Antimicrobial Activities of Bronchus Disease-Inducing Bacteria of Fermented Platycodon grandiflorum Root by Lactic Acid Bacteria
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Changes in Platycoside Components and Antimicrobial Activities of Bronchus Disease-Inducing Bacteria of Fermented Platycodon grandiflorum Root by Lactic Acid Bacteria
Lee, Ka Soon; Seong, Bong Jae; Kim, Sun Ick; Jee, Moo Geun; Park, Saet Byeol; Park, Myeong Hee; Park, Shin Young; Kim, Hyun Ho;
  PDF(new window)
 Abstract
This study was performed in order to investigate changes in platycosides, as well as antimicrobial activities of bronchus diseases-inducing bacteria (Corynebacterium diphtheriae, Klebsiella pneumoniae, Staphylococcus aureus, and Streptococcus pyogenes) of Platycodon grandiflorum root (PGR) fermented by lactic acid bacteria (Leuconostoc mesenteroides N12-4, Leuc. mesenteroides N58-5, Lactobacillus plantarum N76-10, L. plantarum N56-12, Lactobacillus brevis N70-9, and L. brevis E3-8). Growth of L. plantarum on PGR was most active during lactic acid fermentation using different strains. Total platycoside, platycoside E, platycodin A, polygalacin , polygalacin D, and diapioplatyco-side E contents of PGR fermented for 96 h at by Leuc. mesenteroides and L. plantarum increased, whereas contents of platycodin D and platycodin were reduced. The antimicrobial activity on PGR fermented by L. plantarum N56-12 exhibited strong microbial proliferation for all four kinds of bronchus disease-inducing bacteria and was higher than that of non-fermented PGR extract. MIC of fermented PGR extract by L. plantarum N56-12 on C. diphtheriae, K. pneumoniae, S. aureus, and S. pyogenes were 45, 10, 50, and 25 mg/mL, respectively. Thus, this result shows that the antimicrobial activities of bronchus disease-inducing bacteria and platycoside content of PGR by L. plantarum N56-12 were higher than that of non-fermented PGR extract.
 Keywords
Platycodon grandiflorum root;fermentation;lactic acid bacteria;platycosides;antimicrobial activity;
 Language
Korean
 Cited by
 References
1.
Lim KH. 1971. A medicinal phytology (the details). Dongmyoungsa, Seoul, Korea. p 281.

2.
Chang YJ, Kim E, Choi YS, Jeon KH, Kim YB. 2015. Development process for decreasing bitterness of doraji (Platycodon grandiflorum). J Korean Soc Food Sci Nutr 44: 1550-1557. crossref(new window)

3.
Lee IS, Choi MC, Moon HY. 2000. Effect of Platycodon grandiflorum A. DC extract on the bronchus diseases bacteria. Korean J Biotechnol Bioeng 15: 162-166.

4.
Seo JK, Chung YC, Chun SS, Lee YY, Lee SJ, Shon MY, Sung NJ. 2004. Effect of physiologically active compounds isolated from Platycodon grandiflorum on streptozotocin-induced diabetic rats. J Korean Soc Food Sci Nutr 33: 981-986. crossref(new window)

5.
Zhao HL, Cho KH, Ha YW, Jeong TS, Lee WS, Kim YS. 2006. Cholesterol-lowering effect of platycodin D in hypercholesterolemic ICR mice. Eur J Pharmacol 537: 166-173. crossref(new window)

6.
Seo EK, Kim KS, Lee TK, Woo DY, Kim CH, Lee YC. 2000. Effect of dietary Platycodon grandiflorum on plasma glucose and lipid metabolism in KK-Ay mice and streptozotocin-induced diabetic rats. Int J Oriental Med 1: 14-20.

7.
Byun BH. 2003. Antiobesity effects of Platycodon grandiflorum extract on body weight changes and serum lipid profiles of obese rats induced high fat diet. Korean J Life Sci 13: 896-902. crossref(new window)

8.
Lee JY, Hwang WI, Lim ST. 1998. Effect of Platycodon grandiflorum DC extracts on the growth of cancer cell lines. Korean J Food Sci Technol 30: 13-21.

9.
Kim YS, Lee BE, Kim KJ, Lee YT, Cho KB, Chung YC. 1998. Antitumor and immunomodulatory activities of the P. grandiflorum cultivated for more than 20 years. Yakhak Hoeji 42: 382-387.

10.
Kim CH, Jung BY, Jung SK, Lee CH, Kim BH, Kim SK. 2010. Evaluation of antioxidant activity of Platycodon grandiflorum. J Environ Toxicol 25: 85-94.

11.
Jang JR, Hwang SY, Lim SY. 2011. Inhibitory effect of extracts of Platycodon grandiflorum (the ballon flower) on oxidation and nitric oxide production. Korean J Food Preserv 18: 65-71. crossref(new window)

12.
Akiyama T, Tanaka O, Shibata S. 1972. Chemical studies on the oriental plant drugs. XXX. Sapogenins of the roots of Platycodon grandiflorum A. DE CANDOLLE. (1). Isolation of the sapogenins and the stereochemistry of polygalacic acid. Chem Pharm Bull 20: 1945-1951. crossref(new window)

13.
Tada A, Kaneiwa Y, Shoji J, Shibata S. 1975. Studies on the saponins of the root of Platycodon grandiflorum A. De Candolle. I. Isolation and the structure of platycodin-D. Chem Pharm Bull 23: 2965-2972. crossref(new window)

14.
Chung JH, Shin PG, Ryu JC, Jang DS, Cho SH. 1997. Chemical compositions of Platycodon grandiflorus (jacquin) A. De Candolle. Agric Chem Biotechnol 40: 148-151.

15.
Chung JH, Shin PG, Ryu JC, Jang DS, Cho SH. 1997. Pharmaceutical substances of Platycodon grandiflorus (jacquin) A. De Candolle. Agric Chem Biotechnol 40: 152-156.

16.
Shon MY, Seo JK, Kim HJ, Sung NJ. 2001. Chemical compositions and physiological activities of doraji (Platycodon grandiflorum). J Korean Soc Food Sci Nutr 30: 717-720.

17.
Choi JS, Yoo DS, Choi YH, Yon GH, Hong KS, Lee BH, Kim HJ, Kim HK, Kim EJ, Roh SH, Jeong YC, Kim YS, Ryu SY. 2007. Variation of saponin content in the decoctions of Platycodi Radix. Kor J Pharmacogn 38: 128-132.

18.
Yoo DS, Choi YH, Cha MR, Choi CW, Kim MR, Yon GH, Hong KS, Lee BH, Kim EJ, Cho SW, Kim YS, Ryu SY, Kang JS. 2010. Variation of saponin content in the decoctions of Platycodi Radix (II). Kor J Pharmacogn 41: 147-152.

19.
Lee BJ, Shin YY, Lee SW, Chun HS, Cho YS. 2014. Effects of storage methods and periods on root hardness and content of saponin in Platycodon grandiflorum Radix. Korean J Crop Sci 59: 134-138. crossref(new window)

20.
Lee BJ, Cho YS. 2014. Effects of drying temperature on the saponin and free sugar contents of Platycodon grandiflorum Radix. Korean J Food Sci Technol 46: 769-772. crossref(new window)

21.
Lee BJ, Jeon SH, Lee SW, Chun HS, Cho YS. 2014. Effects of drying methods on the saponin and mineral contents of Platycodon grandiflorum Radix. Korean J Food Sci Technol 46: 636-640. crossref(new window)

22.
Ha IJ, Chung JW, Ha YW, Shun EM, Kim YS. 2008. Compositional analysis of major saponins and anti-inflammatory activity of steam-processed Platycodi Radix under pressure. Nat Prod Sci 14: 274-280.

23.
Kim HJ, Park SK, Kim BY, Hong SK, Cho SK, Kim D. 2008. Development of a natural surfactant from extracts of Platycodon grandiflorum. Korean J Chem Eng Res 46: 227-232.

24.
Jeong MK, Shon EH. Hwang YS, Kim HJ, Lee SK, Kim CK. 2013. Immune and anticancer activities enhanced composition containing the Platycodon grandiflorum fraction from the Platycodon grandiflorum roots with high purity platycosides. Korea Patent 10-1322718.

25.
Lee SH, Choi JH, Kim TH, Yoo HJ, Kim KH, Lee SK. 2013. Manufacturing methods of fermentation bellflower increased an effective ingredient. Korea Patent 10-1290795.

26.
Bae MJ, Kim SJ, Cho MS, Um YB, Bae MI. 2014. Fermentation characteristic of Yeongdeok Bobsikhae to which a natural substance (Bellflower) was added. Korean J Food Preserv 21: 350-356. crossref(new window)

27.
Lee KS, Kim JN, Jeong HC. 2015. Study on anti-oxidative activities and beverage preferences relating to fermented Lotus root and Platycodon grandiflorum extracts with sugar through lactic acid fermentation. J East Asian Soc Diet Life 25: 183-192. crossref(new window)

28.
Kang YH, Kim KK, Kim TW, Yang CS, Choe M. 2015. Evaluation of the anti-obesity activity of Platycodon grandiflorum root and Curcuma longa root fermented with Aspergillus oryzae. Korean J Food Sci Technol 47: 111-118. crossref(new window)

29.
Kim HK, Choi JS, Yoo DS, Choi YH, Yon GH, Hong KS, Lee BH, Kim HJ, Kim EJ, Roh SH, Jeong YC, Kim YS, Ryu SY. 2007. HPLC analysis of saponins in Platycodi Radix. Kor J Pharmacogn 38: 192-196.

30.
Lee IS, Moon HY. 2012. Antimicrobial activity on respiration diseases inducing bacteria and antioxidant activity of water extracts from wild edible vegetables. Korean Soc Biotechnol Bioeng J 27: 114-120.

31.
Li W, Zhang M, Wang Z, Wang YP. 2011. Simutaneous RPHPLC determination of six platycosides: application to an enzymatic preparation study. Chromatographia 74: 777-782. crossref(new window)

32.
Ha IJ, Ha YW, Kang M, Lee J, Park D, Kim YS. 2010. Enzymatic transformation of platycosides and one-step separation of platycodin D by high-speed countercurrent chromatography. J Sep Sci 33: 1916-1922. crossref(new window)

33.
Yun YS. 2013. Antioxidant activity, immune activation effects, and saponin content analysis of fermented ginseng flower-buds. MS Thesis. Chungnam University, Daejeon, Korea. p 35-40.

34.
Kang BH, Lee KJ, Hur SS, Lee DS, Lee SH, Shin KS, Lee JM. 2013. Ginsenoside derivatives and quality characteristics of fermented ginseng using lactic acid bacteria. Korean J Food Preserv 20: 573-582. crossref(new window)

35.
Choi YH, Yoo DS, Cha MR, Choi CW, Kim YS, Choi SU, Lee KR, Ryu SY. 2010. Antiproliferative effects of saponins from the roots of Platycodon grandiflorum on cultured human tumor cells. J Nat Prod 73: 1863-1867. crossref(new window)

36.
Kim J. 2014. Antibacterial and anti-inflammatory effects of Platycodon grandiflorum extracts. J Digital Convergence 12: 359-366.