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In Vitro Screening for Anti-Dementia Activities of Seaweed Extracts
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 Title & Authors
In Vitro Screening for Anti-Dementia Activities of Seaweed Extracts
Son, Hyun Jung; Um, Min Young; Kim, Inho; Cho, Suengmok; Han, Daeseok; Lee, Changho;
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We investigated that methanolic extracts of 20 kinds of seaweeds from Jeju Island for their antioxidant activities, acetylcholinesterase and -secretase inhibitory activities, and neuronal survival in order to evaluate their potentials as anti-dementia agents. Ecklonia cava extracts had the highest total polyphenol content among the 20 seaweed extracts. The antioxidant activity of seaweed extracts was measured by using 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assay. It was found that Ecklonia kurome extracts had the highest ABTS scavenging activity (). As a result, Ecklonia cava, Ecklonia kurome, and Myelophycus simplex extracts were found to be the most effective in terms of acetylcholinesterase inhibitory activity. In the -secretase activity assay, Ecklonia cava and Ecklonia kurome extracts were effectively inhibited ( and , respectively). As expected, neuronal cell death induced by in SH-SY5Y cells was diminished by Ecklonia cava, Ecklonia kurome, and Sargassum yezoense extracts. Taken together, these results showed that Ecklonia cava extract has potential anti-dementia activity, which suggests that it might provide an effective strategy for improving dementia.
seaweed extracts;Alzheimer's disease;acetylcholinesterase;antioxidant activity;neuroprotective effect;
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