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Pancreatic Lipase Inhibitors in the Roots of Taraxacum ohwianum, a Herb Used in Korean Traditional Medicine
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  • Journal title : Korean Journal of Food Preservation
  • Volume 18, Issue 1,  2011, pp.53-58
  • Publisher : The Korean Society of Food Preservation
  • DOI : 10.11002/kjfp.2011.18.1.053
 Title & Authors
Pancreatic Lipase Inhibitors in the Roots of Taraxacum ohwianum, a Herb Used in Korean Traditional Medicine
Kim, Tae-Wan; Kim, Tae-Hoon;
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Activity-guided isolation from an ethylacetate-soluble fraction of a 70% (v/v) ethanolic extract from the roots of Taraxacum ohwianum, using a pancreatic lipase inhibition assay, resulted in isolation and identification of five phenolic metabolites of previously known structure; these were 3,5-di-O-caffeoylquinic acid, chicoric acid, caffeic acid, protocatechuic aldehyde, and luteolin. All structures were confirmed by NMR and MS scpectroscopic data. Of these compounds 3,5-di-O-caffeoylquinic acid exhibited the most potent inhibitory activity, with of against pancreatic lipase.
Taraxacum ohwianum;pancreatic lipase inhibition;caffeic acid derivatives;
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Bray GA, Popkin BM (1998) Dietary fat intake dose affect obesity. Am J Clin Nutr, 68, 1157-1173

Bray GA, Popkin BM (1999) Dietary fat affects obesity rate. Am J Clin Nutr, 70, 572-573

Freedman DS, Serdula MK, Perey CA, Whitle L (1997) Obesity levels of lipids and glucose, and smoking among Navajo adolescents. J Nutr, 127, 2120-2127

Rexrode KM, Manson JE, Hennekens CH (1996) Obesity and cardiovascular disease, Curr Opin Cardiol, 11, 490-495 crossref(new window)

Bitou N, Nimomiya M. Tsjita T, Okuda H (1999) Screening of lipase inhibitors from marine algae. Lipids, 34, 441-445 crossref(new window)

Drent ML, Larsson I, William-Olsson T, Quaade F, Czubayko F, Von Bergmann K, Strobel W, Sjotro L, Van der Veen EA (1995) Orlistat (RO 18-0647), a lipase inhibitor, in the treatment of human obesity: a multiple dose study. Int J Obesity, 19, 221-226

Hadvay P, Lengsfeld H, Wolter H (1988) Inhibition of pancreatic lipase in vitro by covalent inhibitor tetrahydrolipstatin, Biochem J, 256, 357-361 crossref(new window)

Peter C, Williams G (2001) Drug treatment of obesity: from past failures to future successes. Br J Clin Pharmacol, 51, 135-141

Yamamoto M, Shimura Y, Iyoh M Egawa, S Ionue (2000) Anti-obesity effects of lipase inhibitor CT-II, an extract from edible herbs, Nomame Herba, on rats fed a high-fat diet. Int J Obesity, 24, 758-764 crossref(new window)

Birari RB, Bhutani KK (2007) Pancreatic lipase inhibitors from natural sources: unexplored potential. Drug Dicov Today, 12, 879-889 crossref(new window)

Lee EM, Lee SS, Chung BY, Cho JY, Lee IC, Ahn SR, Jang SJ, Kim TH (2010) Pancreatic lipase inhibition by C-glucosidic flavones isolated from Eremochloa ophiuroides. Molecules, 15, 8251-8259 crossref(new window)

Hong JY, Shin SR, Bae MJ, Bae JS, Lee IC, Kwon OJ, Jung JW, Kim YH, Kim TH (2010) Pancreatic lipase inhibitors isolated from the leaves of cultivated mountain ginseng (Panax ginseng). Korean J Food Preserv, 17, 727-732

Kim TH, Kim JK, Ito H, Jo C (2011) Enhancement of pancreatic lipase inhibitory activity of curcumin by radiolytic transformation. Bioorg Med Chem Lett. 21, 1512-1514 crossref(new window)

Kang BS (2000) Bonchohak, 6th edition, Young Lim Sa, Seoul, Korea.

Namba T (1993) The encyclopedia of Wakan-yaku with color pictures vol 1, 68-71, Hoikusha, Osaka, Japan.

Hwang KH, Park TK (2006) The inhibitory activity of the Taraxacum mongolicum on monoamine oxidase. Korean J Pharmacogn, 37, 229-234

Kim JH, Kim HJ, Park HW, Youn SH, Choi DY, Shin CS (2007) Development of inhibitors against lipase and alpha-glucosidase from derivatives of monascus pigment. FEMS Microbiol Lett, 276, 93-98 crossref(new window)

Zhu X, Zhang H, Lo R (2004) Phenolic compounds from the leaf extract of Artichoke (Cynara scolymus L.) and their antimicrobial activities. J Agric Food Chem, 62, 7272-7278

Vett M, Strack D, Czygan F-C, Wray V, Witte L (1991) Di-E-caffeoyl-meso-tartaric acid in the barren sprouts of Equisetum arvense. Phytochemistry, 30, 527-529 crossref(new window)

Kwon YS, Won HM, Kim CM (2000) Flavonoids from Indigofera pseudo-tinctoria stem. Korean J Pharmacogn, 31, 280-283

Xu M, Zhang Z, Fu G, Sun J, Yang M, Liu Z, Han J, Guo D (2007) Liquid chromatography-tandem mass spectrometry analysis of protocatechuic aldehyde and its phase I and II metabolites in rat. J Chromatogr, 856, 100-107 crossref(new window)

Markham KR, Ternai B, Stanley R, Geiger H, Marbry TJ (1978) Carbon-13 NMR studies of flavonoids-III: Naturally occurring flavonoid glycosides and their acylated derivatives. Tetrahedron, 34, 1389-1397 crossref(new window)

Jung HA, Islam MD, Kwon YS, Jin SE, Son YK, Park JJ, Sohn HS, Choi JS (2010) Extraction and identification of three major aldose reductase inhibitors from Artemisia montana. Food Chem Toxicol, In press.

Lee BI, Nugroho A, Bachri MS, Choi J, Lee KR, Kim WB, Lee KT, Lee JD, Park HJ (2010) Anti-ulcerogenic effect and HPLC analysis of the caffeoylquinic acid-rich extract from Ligularia stenocephala. Biol Pharm Bull, 33, 493-497 crossref(new window)

Satake T, Kamiya K, An Y, Oishi Nee Taka T, Yamamoto J (2007) The anti-thrombotic active constituents from Centella asiatica. Biol Pharm Bull, 30, 935-940 crossref(new window)