JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Pancreatic Lipase Inhibitory and Antioxidant Activities of Polygonum aviculare Extract
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
  • Journal title : Korean Journal of Food Preservation
  • Volume 18, Issue 2,  2011, pp.250-255
  • Publisher : The Korean Society of Food Preservation
  • DOI : 10.11002/kjfp.2011.18.2.250
 Title & Authors
Pancreatic Lipase Inhibitory and Antioxidant Activities of Polygonum aviculare Extract
Kim, Tae-Hoon;
  PDF(new window)
 Abstract
As part of our continuing search for novel bioactive natural products, antioxidant and pancreatic lipase inhibitory activities of the aqueous ethanolic extract of Polygonum aviculare were investigated. In addition, the total phenolic content was quantified by a spectrophotometric method. The antioxidant properties of the extract were evaluated by radical scavenging assays such as DPPH and radicals. The anti-obesity efficacy of P. aviculare extract was tested by porcine pancreatic lipase assay. All tested samples showed a dose-dependent pancreatic lipase inhibitory and radical scavenging activities. In terms of the value, the ethyl acetate (EtOAc) soluble portion was most potent than other solvent soluble portions. The results suggested that P. aviculare could be considered as a new potential source of natural antioxidant and anti-obesity agent for food, nutraceutical, cosmetics industries.
 Keywords
Polygonum avicuiare;pancreatic lipase inhibition;antioxidant activity;DPPH;;
 Language
Korean
 Cited by
1.
약용식물 추출물의 항산화 활성,박혜진;강선애;이주영;조영제;

한국식품저장유통학회지, 2012. vol.19. 5, pp.744-750 crossref(new window)
 References
1.
Shim JS, Kim SD, Kim TS, Kim KN (2005) Biological activities of flavonoid glycosides isolated from Angelica keiskei. Korean J Food Sci Technol, 37, 78-83

2.
Branen AL (1975) Toxicology and biochemistry of butylated hydroxy anisole and bytylated hydoxytoluane. J Oil Chem Soc, 52, 59-62 crossref(new window)

3.
Masaki H, Sakaki S, Atsumi T, Sakurai H (1995) Active-oxygen scavenging activity of plants extracts. Biol Pharm Bull, 18, 162-166 crossref(new window)

4.
Bray GA, Popkin BM (1998) Dietary fat intake dose affect obesity. Am J Clin Nutr, 68, 1157-1173

5.
Bray GA, Popkin BM (1999) Dietary fat affects obesity rate. Am J Clin Nutr, 70, 572-573

6.
Freedman DS, Serdula MK, Perey CA, Whitle L (1997) Obesity levels of lipids and glucose, and smoking among Navajo adolescents. J Nutr, 127, 2120-2127

7.
Rexrode KM, Manson JE, Hennekens CH (1996) Obesity and cardiovascular disease, Curr Opin Cardiol, 11, 490-495 crossref(new window)

8.
Bitou N, Nimomiya M. Tsjita T, Okuda H (1999) Screening of lipase inhibitors from marine algae. Lipids, 34, 441-445 crossref(new window)

9.
Drent ML, Larsson I, William-Olsson T, Quaade F, Czubayko F, Von Bergmann K, Strobel W, Sjotro L, Van der Veen EA (1995) Orlistat (RO 18-0647), a lipase inhibitor, in the treatment of human obesity: a multiple dose study. Int J Obesity, 19, 221-226

10.
Hadvay P, Lengsfeld H, Wolter H (1988) Inhibition of pancreatic lipase in vitro by covalent inhibitor tetrahydrolipstatin. Biochem J, 256, 357-361 crossref(new window)

11.
Peter C, Williams G (2001) Drug treatment of obesity: from past failures to future successes?. Br J Clin Pharmacol, 51, 13-25

12.
Yamamoto M, Shimura Y, Iyoh M Egawa, S Ionue (2000) Anti-obesity effects of lipase inhibitor CT-II, an extract from edible herbs, Nomame Herba, on rats fed a high-fat diet. Int J Obesity, 24, 758-764 crossref(new window)

13.
Birari RB, Bhutani KK (2007) Pancreatic lipase inhibitors from natural sources: unexplored potential. Drug Dicov Today, 12, 879-889 crossref(new window)

14.
Lee EM, Lee SS, Chung BY, Cho JY, Lee IC, Ahn SR, Jang SJ, Kim TH (2010) Pancreatic lipase inhibition by C-glucosidic flavones isolated from Eremochloa ophiuroides. Molecules, 15, 8251-8259 crossref(new window)

15.
Hong JY, Shin SR, Bae MJ, Bae JS, Lee IC, Kwon OJ, Jung JW, Kim YH, Kim TH (2010) Pancreatic lipase inhibitors isolated from the leaves of cultivated mountain ginseng (Panax ginseng). Korean J Food Preserv, 17, 727-732

16.
Kim TH, Kim JK, Ito H, Jo C (2011) Enhancement of pancreatic lipase inhibitory activity of curcumin by radiolytic transformation. Bioorg Med Chem Lett. 21, 1512-1514 crossref(new window)

17.
Lee CG, Kim NJ, Hong ND, Kwon CH (1994) Anti-lipid peroxidation and liver protective effects of Polygonum aviculare L. Korean J Pharmacogn, 25, 59-69

18.
Al-Hazimi HM, Haque SN (2002) A new naphthoquinone from Polygonum aviculare. Nat Prod Lett, 16, 115-118 crossref(new window)

19.
Inokuchi J, Okabe H, Yamaguchi T, Nagamatsu A, Nonaka G, Nishioka I (1985) Inhibitors of angiotensin- converting enzyme in crude drugs. II. Chem Pharm Bull, 33, 264-269 crossref(new window)

20.
Nan JX, Park EJ, Kim HJ, Ko G, Sohn DH (2000) Antifibrotic effects of methanol extract of Polygonum aviculare in fibrotic rats induced by bie duct ligation and scission. Biol Pharm Bull, 23, 240-243 crossref(new window)

21.
Tunon H, Olavsdotter C, Bohlin L (1995) Evaluation of anti-inflammatory activity of some Swedish medicinal plants. Inhibition of prostaglandin biosynthesis and PAF-induced exocytosis. J Ethnopharmacol, 48, 61-76 crossref(new window)

22.
Gao X, Bjor, L, Trajkovski V, Uggla M (2000) Evaluation of antioxidant activities of rosehip ethanol extracts in different test system. J Sci Food Agric, 80, 2021-2027 crossref(new window)

23.
Blois MS (1958) Antioxidant activity determination by the use of a stable free radical. Nature, 181, 1199-1200 crossref(new window)

24.
Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C (1999) Antioxidnt activity applying and improved ABTS radical cation decolorization assay. Free Radic Biol Med, 26, 1231-1237 crossref(new window)

25.
Kim JH, Kim HJ, Park HW, Youn SH, Choi DY, Shin CS (2007) Development of inhibitors against lipase and alpha-glucosidase from derivatives of monascus pigment. FEMS Microbiol Lett, 276, 93-98 crossref(new window)

26.
Torel J, Gillard J, Gillard P (1986) Antioxidant activity of flavonoids and reactivity with peroxy radical. Phytochemistry, 25, 383-385 crossref(new window)

27.
Wang SY, Chang HN, Lin KT, Lo CP, Yang NS, Shyur LF (2003) Antioxidant properties and phytochemical characteristics of extracts from Lactuca indica. J Agric Food Chem, 26, 1506-1512

28.
Cooke D, Bloom S (2006) The obesity pipeline: current strategies in the development of anti-obesity drugs. Nat Rev Drug Discov, 5, 919-1200 crossref(new window)

29.
Kim HY, Kang MH (2005) Screening of Korean medicinal plants for lipase inhibitory activity. Phytother Res, 19, 359-361 crossref(new window)

30.
Sugiyama H, Akazome Y, Shoji T, Yamaguchi A, Yasue M, Kanda T, Ohtake Y (2007) Oligomeric procyanidins in apple polyphenol are main active components for inhibition of pancreatic lipase and triglyceride absorption. J Agric Food Chem, 55, 4604-4609 crossref(new window)

31.
Liu W, Zheng Y, Han L, Wang H, Saito M, Ling M, Kimura Y, Feng Y (2008) Saponins (Ginsenosides) from stems and leaves of Panax quinquefolium prevented high-fat diet induced obesity in mice. Phytomedicine, 15, 1140-1145 crossref(new window)