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Antibacterial, Antioxidative and Anti-proliferative Activity against Human Colorectal Cell of Pimpinella brachycarpa
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  • Journal title : Korean Journal of Food Preservation
  • Volume 18, Issue 4,  2011, pp.590-596
  • Publisher : The Korean Society of Food Preservation
  • DOI : 10.11002/kjfp.2011.18.4.590
 Title & Authors
Antibacterial, Antioxidative and Anti-proliferative Activity against Human Colorectal Cell of Pimpinella brachycarpa
Ahn, Seon-Mi; Kim, Mi-Sun; Jung, In-Chang; Sohn, Ho-Yong;
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Pimpinella brachycarpa, called as cham-na-mul in Korea, is an edible popular herb. However, the study of biological activity of P. brachycarpa is still rudimentary in worldwide. In this study, from the cultivated P. brachycarpa, we prepared the methanol extract and its subsequent solvent fractions, and their antimicrobial, antioxidation, and anti-proliferative activities were evaluated. The fraction yields of n-hexane (H), methylene chloride (EC), ethylacetate (EA), butanol (B), and water residue (W) from the methanol extract were 18.71, 0.7, 0.56, 4.57, and 71.51%, respectively. Analysis of total flavonoid and total polyphenol showed that the EA fraction contained the highest contents (89.23 and 200 mg/g), and the W residue has the lowest contents (19.6 and 2.27 mg/g) among the factions. In antimicrobial activity assay, the EA fraction showed a broad-range antibacterial activity, while the H fraction is effective against gram positive bacteria. In antioxidation activity assay, EA and B fraction showed strong DPPH anion and ABTS cation scavenging activities including reducing power, and Hand MC fraction showed effective nitrite scavenging activity (71.43~83.82 /mL of ). In a while, only B fraction showed strong anti-proliferative activity against human colorectal cancer HCT-116 (166 /mL of ) as a dose-dependent manner up to 200 /mL. These results suggest that the EA and B fraction of P. brachycarpa could be developed as functional food ingredients.
antibacterial;antioxidant;anti-proliferative;Pimpinella brachycarpa;
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