Advanced SearchSearch Tips
-Glucosidase Inhibitory Substances Exploration Isolated from the Herb Extract
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
  • Journal title : Korean Journal of Food Preservation
  • Volume 18, Issue 4,  2011, pp.620-625
  • Publisher : The Korean Society of Food Preservation
  • DOI : 10.11002/kjfp.2011.18.4.620
 Title & Authors
-Glucosidase Inhibitory Substances Exploration Isolated from the Herb Extract
Choi, Gil-Yong; Han, Gab-Jo; Ha, Sang-Chul;
  PDF(new window)
This is a part of the study on the food materials that are effective for diabetes treatment and for use in the development of functional bread products. In this study, various commercially available Oriental medicines with the intestinal absorption enzyme called -glucosidase, which is known to be effective for diabetes treatment, were explored. According to the research results on the water and methanol in 200 kinds of Oriental medicines, which were separated by layer to investigate the inhibitory activity of -glucosidase, Astragalus membranaceus (70.9%) in the water layer and Pericaeta communissima (72.9%) in the MeOH layer showed a strong inhibitory effect of over 70%. Myristica fragrans (69%), Morus alba (66.9%), Schisandra chinensis (65%), Panax notoginsens (63.9%), Anthriscus sylvestris (62.9%), Asparagus cochinchinensis (62.1%), Erycibe obtusifolia (60.9%), Polygonum cuspidatum (60.7%), Atractylodes lancea (60.2%), and Perilla frutescens (60.2%) in the water layer, and Codonopsis pilosula (67.8%), Prunus persica batsch (67.6%), Sinomenium acutum (63.5%), and Malvae semen (61.6%) in the MeOH layer, showed a more than 60% inhibitory effect. Thirty one species, including Polygonatum sibiricum (59.8%), Medicata fementata (59.7%), Alisma canaliculatum (59.5%), Coix lacryma-jobi (59.2%), Asiasarum sieboldi (59.0%), and Bupleurum falcatum (53.0%), in the water layer, and 10 species [Quisqualis indica (58.8%), Lycium chinense (58.3%), Trichosanthes kirilowii (58.0%), Thuja orientalis (55.9%), Bombyx mori (55.6%), Gallus domesticus (55.4%), Aralia continentalis (55.3%), Cibotium barometz (52.7%), Euphorbia pekinensis (52.7%), and Dolichos lablab (52.5%)] in the MeOHlayer, showed a more than 50% inhibitory effect. Therefore, such materials are expected to be the basic materials that will be used for the development of functional materials for diabetes treatment.
-glucosidase;medicinal herb;diabetes;exploration;bread applied;
 Cited by
약용식물 물 추출물의 항산화 활성 및 α-Glucosidase 저해효과,김현숙;김태우;김대중;이재성;김경곤;최면;

한국약용작물학회지, 2013. vol.21. 3, pp.197-203 crossref(new window)
산사 추출물의 항산화 및 항당뇨 활성,남상명;강일준;신미혜;

동아시아식생활학회지, 2015. vol.25. 2, pp.270-277 crossref(new window)
Anti-diabetic and Anti-oxidative activities of Extracts from Crataegus pinnatifida, Journal of the East Asian Society of Dietary Life, 2015, 25, 2, 270  crossref(new windwow)
The Literature Study of Research Trend of Alismatis Rhizoma and Relationship Between the Herbology and KCD, The Korea Journal of Herbology, 2016, 31, 2, 47  crossref(new windwow)
Kim IS, Ju EJ, Lee KJ, Park ES (2003) Clinical nutrition and dietetic treatment, Hyoil, p 259

Korean Center for disease control and Prevention. the fourth Korea National Health and Nutrition Examination Survey KNHANES IV-2 (2009). Seoul: Korea Centers for Disease Control and Prevention

Park YM, Sohn CM, Jang HC (2005) A study on status subjective recogniti on of functional foods among diabetic patients. J Korean Diet Assoc, 11, 216-222

Park YM (2010) Proper nutrition for diabetes patients dietitan, chonbuk national university hospital, jeonju, Korea. Korean Clinical Diabetes J, 11, 303-308

Xiang Z, He F, Kang TG, Dou DQ, Gai K, Shi YY, Kim YH, Dong F (2010) Anti-dia betes constituents in leaves of Smallanthus sonchifolius. Nat Prod Commun, 5, 95-98

Pyorala K, Laakso M, Uusitupa M (1987) Diabetes and atherosclerosis: an epidem iolo gic view. Diabetes Metab Rev, 3, 463-524 crossref(new window)

Fiordaliso M, Kok N, Desager JP, Goethals F, Deboyser D, Roberfroid M, Delzenne N (1995) Dietary oligofructose lowers triglycerides, phospholipids and cholesterol in serum and very iow density lipoproteins of rats. Lipids, 30, 163-167 crossref(new window)

Yoon JW, Rhee SK, Lee KB (2005) Effects of silkworm extract powder on plasma lipids and glucose rats. Korean J Food Nutr, 18, 140-145

Lee HA, Sim HS, Choi KJ, Lee HB (1998) Hypoglycemic action of red ginseng components(II):Investigation of the effect of fat soluble fraction from red ginseng on enzymes related to glucose metabolism in cultured rat hapatocytes. Korean J Ginseng Sci, 22, 51-59

Kim SH, Ryu DS, Lee MY, Kim KH, Kim YH, Lee DS (2008) Antidiabetic activity of polysaccharide on salicornia herbacea. Korean J Microbiol Biotechnol, 36, 43-48

Puls W, Keup U (1973) Influence of an ${\alpha}-amylase$ inhibitor (Bay d7791) on blood glucose, serum insulin and NEFF in starch loading tests in rats, dogs and man. Diabetologia, 9, 97-101 crossref(new window)

Puls HP, Krause L, Muller H, Schutt R, Thomas G (1984) Inhibitors of the rate of carbohydrate and lipid absorption by the intestine. Int J Obes, 8, 181-190

Toeller M, Klischan A, Heitkamp G, Schumacher W, Milne R, Buyken A, Karam anos B, Gries FA, the EURODIAB IDDM Complications Study Group (1996) Nutritional intake of 2868 IDDM patients from 30 centres in Europe. Diabetologia, 39, 929-939 crossref(new window)

McCue P, Shetty K (2004) Inhibitory effects of rosmarinic acid extracts on porcine pancreatic amylas in vitro. Asia Pac J Clin Nutr, 13, 101-106

Del Prato, S Bianchi C, Marchetti P (2007) Beta-cell function and anti-diabetic pharmacotherapy. Diabetes Metab Res Rev, 23, 518-527 crossref(new window)

Van de Laar, F A Lucassen, P L Akkermans, R P Van de Lisdonk E H. D Grauw WJ (2009) Alpha-glucosidase inhibitors for prople with impaired glucose tolerance or impaired fasting blood glucose. Cochrane Database Syst Rev, 18, CD005061

Tibbot BK, Skadsen RW (1996) Molecular cloning and characterization of a gibberellin-inducible, putative ${\alpha}-glucosidasc$ gene from berley. Plant Mol Biol, 30, 229-241 crossref(new window)

Nam MS, Kim KR, Cho JH, Lee KM, Park HY, Lee EJ, Lim SK, Lee HC, Huh KB (1994) A study on the folk remedies by the questionnaries in Korean diabetic patients. Diabetes, 18, 242-248

Mitsunnaga T. Abe L, Kontani M, Ono H, Tanaka T (1997) Inhibitory effects of bark proanthocynaidins on the activities of glucosyltransferases of streptococcus sobr inus. L. Wood Shem. Korean J Food & Nutr, 17, 327-340

Lee WY, Ahn JK, Park YK, Rhee HI (2004) Inhibitory effects of proanthocyanidin extracted from distylium racemosum on ${\alpha}-amylase$ and ${\alpha}-glucosidase$ Activities. Kor J Pharmacogn, 35, 271-275

Kang TH, Choi SZ, Lee TH, Son MW, Kim SY (2008) Characteristics of antidia betic effect of dioscorea rhizoma (1). Korean J Food & Nutr, 21, 425-429

Shin Je, Han MJ, Lee IK, Mon YI, Kim DH (2003) Hypoglycemic activity of opuntia ficus-indica var. sabotan on Alloxan or Streptozotocin-Induced Diabetic Mice. Kor J Pharmacogn, 34, 75-79

Hikino H, Mizuno T, Oshima Y, Konno C (1985) Isolation and hypoglycemic acticity of Moran A, a glycoprotein of Morus Alba Root Barks. Planta Medica, 159-162

Kimura M, Chen FJ, Nakashima N, Kimura I, Asano N, Koya S (1995) Antihyper glycemic effects of N-containing sugers derived from Mulberry leaves in strepto-zotocininduced diabetic mice. J Trad Med, 12, 214-219

Noh JH, Kim YJ, Kim SW, Lee JH, Lee HY (2003) Comparison of biological activities of Epimedium Koreanum Nakai Produced in Korea and China. Korean J Medicinal Crop Sci, 11, 195-200

Kim JH, Kim MU, Cho YJ (2007) Isolation and identification of inhibitory compound from crataegi fructus on ${\alpha}-glucosidase$. J. Korean soc Appl Biol Chem, 50, 204-209

Cha MR, Park JH, Choi YH, Choi CW, Hong KS, Choi SU (2009) Alpha-glucosidase inhibitors from the branches extract of cotinus coggygria. Kor J Pharmacogn, 40, 229-232

Kim DH, Choi HJ, Bae EA, Hsn MJ, Park SY (1998) Effect of Artificially cultured phellinus linteus on harmful intestinal bacterial enzymes and rat intestinal ${\alpha}-glucosida$ ses. J Fd Hyg Safety, 13, 20-23