JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Effect of the extracts from Schisandra chinensis Fruit and Morus alba Leaf on Insulin Secretion in Glucose-induced HIT-T15 Cells
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
  • Journal title : Korean Journal of Food Preservation
  • Volume 18, Issue 6,  2011, pp.1002-1008
  • Publisher : The Korean Society of Food Preservation
  • DOI : 10.11002/kjfp.2011.18.6.1002
 Title & Authors
Effect of the extracts from Schisandra chinensis Fruit and Morus alba Leaf on Insulin Secretion in Glucose-induced HIT-T15 Cells
Jeong, Yoo-Seok; Hong, Joo-Heon; Jung, Hee-Kyoung;
  PDF(new window)
 Abstract
This study aimed to examine the effect of the Schizandra chinensis fruit and Morus alba leaf on insulin expression in HIT-T15 cells, which is exposed by glucose. The total polyphenol contents of the S. chinensis fruit ethanol extract and the M. alba leaf hot-water extract were mg/g and mg/mL, respectively. The S. chinensis fruit ethanol extract and the M. alba leaf hot-water extract contained and mg/g flavonoids, respectively. The antioxidant ability of the M. alba leaf hot-water extract was found to be superior to that of the S. chinensis fruit ethanol extract. Compared to the HIT-T15-treated 10 mM 2-deoxy-D-glucose, the S. chinensis ethanol extract was found to have a two fold increase in insulin productivity. Moreover, the M. alba leaf hot-water extract promoted the insulin secretion of high-glucose-damaged HIT-T15 almost ten fold. The above results showed that the S. chinensis fruit ethanol extract and M. alba leaf hot-water extract may improve the insulin productivity of the beta cell with glucose-induced oxidative damage. These data suggest that the S. chinensis fruit ethanol extract and the M. alba leaf hot-water extract can be used as food materials for the regulation of insulin secretion.
 Keywords
Schizandra chinensis;Morus alba;HIT-T15;insulin secretion;
 Language
Korean
 Cited by
1.
제2형 당뇨질환모델 db/db 마우스에서 부추 추출물 및 유산균 발효물의 항당뇨 효과,김배진;조성경;정유석;정희경;

한국식품저장유통학회지, 2015. vol.22. 1, pp.134-144 crossref(new window)
1.
Anti-diabetic effects of Allium tuberosum rottler extracts and lactic acid bacteria fermented extracts in type 2 diabetic mice model, Korean Journal of Food Preservation, 2015, 22, 1, 134  crossref(new windwow)
 References
1.
Kaprio J, Tuomilehto J, Koskenvuo M, Romanov K, Reunanen A, Eriksson J, Stengard J, Kesaniemi YA (1992) Concordance for type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus in a population-based cohort of twins in Finland. Diabetologia, 35, 1060-1067 crossref(new window)

2.
Butler AE, Janson J, Susan BW, Rizzan RA, Butler PC (2003) $\beta$-Cell deficit and increased $\beta$-cell apoptosis in humans with type 2 diabetes. Diabetes, 52, 102-110 crossref(new window)

3.
Paul R, Jamie H, Phuong OT, Yoshito T, Hiroki T (2003) Glucose Toxicity in $\beta$-Cells: Type 2 Diabetes, Good Radicals Gone Bad, and the Glutathione Connection. Diabetes, 52, 581-587 crossref(new window)

4.
Abir TE, Amany A, Amal JF (2005) Protective effect of red grape seeds proanthocyanidins against induction of diabetes by alloxan in rats. Pharmacol Res, 52, 264-270 crossref(new window)

5.
Paul R, Jamie H, Phuong OT, Vincent P (2004) $\beta$-Cell Glucose Toxicity, Lipotoxicity and Chronic Oxidative Stress in Type 2 Diabetes. Diabetes, 53, 5119-5124

6.
Rodney CR, Roger BM (2001) Use of Antioxidant Nutrients in the Prevention and Treatment of Type 2 Diabetes. J Am Coll Nutr, 20, 363-369 crossref(new window)

7.
Hancke JL, Burgos RA, Ahumada F (1999) Schisandra chinensis(Turcz) Baill. Fitoterapia, 70, 451-471 crossref(new window)

8.
Cho YJ, Ju IS, Kin BC, Lee WS, Kim MJ, Lee BG, An BJ, Kim JH, Kwon OJ (2007) Biological activity of Omija(Schizandra chinessis Bailon). J Korean Soc Appl Biol Chem, 50, 193-203

9.
Rho SN, Oh HS (2002) Effect of Omija(Schizandra chinensis Baillon) extracts on the growth of liver cancer cell line SNU-398. Korean J Nutr, 35, 201-206

10.
Choi JH, Kim DI, Park SH, Kim DW, Lee JS, Ryu KS, Lee WC (1999) Effect of Mulberry leaf extract on oxygen radicals and their scavenger enzymes in serum of rats. Korean J Seric Sci, 41, 135-140

11.
Do GP, Lee HJ, Do JR, Kim HK (2011) Inhibition of adipogenesis in 3t3-L1 adipocytes with water and ethanol extracts of Curdrania tricuspidata leaves. Korean J Food Preserv, 18, 244-249 crossref(new window)

12.
Kim SY, Ryu KS, Lee WC, Ku HO, Lee HS, Lee KR (1999) Hypolycemic effect of Mulberry leaves with anaerobic treatment in allozan-induced diabetic Mice. Kor J Pharmacogn, 30, 123-129

13.
Kim SI, Sim KH, Ju SY, Han YS (2009) A study of antioxidative and hypoglycemic activities of Omija(Schizandra chinensis Baillon) extract under variable extract conditions. Korean J Food and Nutr, 22, 41-47

14.
Singleton VL, Rossi JA (1965) Colorimetry of total phenolics with phenolics with phosphomolybdicphosphotungstic acid reagents. Am J Enol Viticult, 16, 144-158

15.
Jia Z, Tang M, Wu J (1999) The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals. Food Chem, 64, 555-559 crossref(new window)

16.
Lee EJ, Kim JS, Kwon JH (2008) Optimization of microwave-assisted extraction conditions for total catechin and electron donating ability of grape seed extracts. Korean J Food Preserv, 15, 840-846

17.
Talcott ST, Lee JH (2002) Ellagic acid and flavonoid antioxidant content of mascadine wine and juice. J Agri Food Chem, 50, 3186-3192 crossref(new window)

18.
Leng SH, Lu FE, XU LJ (2004) Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretion. Acta Pharmacol Sin, 25, 496-502

19.
Kim JH, Jeong CH, Choi GN, Kwak JH, Choi SG, Heo HJ (2009) Antioxidant and Neuronal cell protective effects of Methanol extract from Schizandra chinensis using an in vitro system. Korean J Food Sci Technol, 41, 712-716

20.
Kim CJ, Suh HJ (2005) Antioxidant activities of Rhubarb extracts containing phenolic compounds. Korean J Food Culture, 20, 77-85

21.
Cho YJ, Chun SS, Kwon HJ, Kim JH, Lee KH, An BJ Choo JW (2006) Inhibitory effects of water and 80% Ethanol extracts from Mulberry leaves(Morus alba L) on angiotensin converting enzyme and xanthine oxidase. J Korean Soc Appl Biol Chem, 49, 114-124

22.
Villano D, Fernandez-Pachon MS, Moya ML, Troncoso AM, Garcia-Parrilla MC (2007) Radical scavenging ability of polyphenolic compounds towards DPPH free radical. Talanta, 71, 230-235 crossref(new window)

23.
Prior RL, Hoang H, Gu L, Wu X, Bacchiocca M, Howard L, Hampsch-Woodill M, Huang D, Ou B, Jacorb R (2003) Assays for hydrophlic and lipophilic antioxidant capacity oxygen radical absorbance capacity (ORAC) of plasma and other biological and food samples. J Agri Food Chem, 51, 3273-3279 crossref(new window)

24.
Kim SH, Kim YM (2007) Determination of the antioxidant capacity of korean ginseng using an ORAC assay. J East Asian Soc Dietary Life, 17, 393-401

25.
Unger J (2008) Reducing oxidative stress in patients with type 2 diabetes mellitus: a primary care call to action. Insulin, 3, 176-184 crossref(new window)

26.
Feillet-Coudraya C, Rock E, Coudray C, Grzelkowska K, Azais-Braesco V, Dardevet D, Mazur A (1999) Lipid peroxidation and antioxidant status in experimental diabetes. Clinica Chimica Acta, 284, 31-43 crossref(new window)

27.
Robertson RP, Zhang HJ, Pyzdrowski KL, Walseth TF (1992) Preservation of Insulin mRNA levels and insulin secretion in HIT cells by avoidance of chronic exposure to high glucose concentrations. J Clin Invest, 90, 320-325 crossref(new window)

28.
Lee YJ, Suh KS, Choi MC, Chon S, Oh SJ, Woo JT, Kim SW, Kim JW, Kim YS (2010) Kaempferol protects HIT-T15 pancreatic beta cells from 2-deoxy-d-riboseinduced oxidative damage. Phytother Res, 24, 419-423 crossref(new window)

29.
Robertson RP, Zhang HJ, Kathryn LP, Timothy FW (1992) Preservation of insulin mRNA levels and insulin secretion in HIT cells by avoidance of chronic exposure to high glucose concentrations. J Clin Invest, 90, 320-325 crossref(new window)

30.
Jung GT, Ju IO, Choi JS (1998) Studies on drying and preservation of Omija(Schizandra chinensis BAILL.). Korean J Food Preserv, 5, 217-223

31.
Jo SH, Ha KS, Moon KS, Lee OH, Jang HD, Kwon YI (2011) In Vitro and in vivo anti-hyperglycemic effects of Omija(Schizandra chinensis) Fruit. Int J Mol Sci, 12, 1359-1370 crossref(new window)

32.
Andallu, B, Varadacharyulu NC (2003). Antioxidant role of mulberry(Morus indica L. cv. Anantha)leaves in streptozotocin-diabetic rats. Clinica Chimica Acta, 338, 3-10 crossref(new window)