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Effect of the extracts from Schisandra chinensis Fruit and Morus alba Leaf on Insulin Secretion in Glucose-induced HIT-T15 Cells
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  • Journal title : Korean Journal of Food Preservation
  • Volume 18, Issue 6,  2011, pp.1002-1008
  • Publisher : The Korean Society of Food Preservation
  • DOI : 10.11002/kjfp.2011.18.6.1002
 Title & Authors
Effect of the extracts from Schisandra chinensis Fruit and Morus alba Leaf on Insulin Secretion in Glucose-induced HIT-T15 Cells
Jeong, Yoo-Seok; Hong, Joo-Heon; Jung, Hee-Kyoung;
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This study aimed to examine the effect of the Schizandra chinensis fruit and Morus alba leaf on insulin expression in HIT-T15 cells, which is exposed by glucose. The total polyphenol contents of the S. chinensis fruit ethanol extract and the M. alba leaf hot-water extract were mg/g and mg/mL, respectively. The S. chinensis fruit ethanol extract and the M. alba leaf hot-water extract contained and mg/g flavonoids, respectively. The antioxidant ability of the M. alba leaf hot-water extract was found to be superior to that of the S. chinensis fruit ethanol extract. Compared to the HIT-T15-treated 10 mM 2-deoxy-D-glucose, the S. chinensis ethanol extract was found to have a two fold increase in insulin productivity. Moreover, the M. alba leaf hot-water extract promoted the insulin secretion of high-glucose-damaged HIT-T15 almost ten fold. The above results showed that the S. chinensis fruit ethanol extract and M. alba leaf hot-water extract may improve the insulin productivity of the beta cell with glucose-induced oxidative damage. These data suggest that the S. chinensis fruit ethanol extract and the M. alba leaf hot-water extract can be used as food materials for the regulation of insulin secretion.
Schizandra chinensis;Morus alba;HIT-T15;insulin secretion;
 Cited by
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