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Anti-melanogenic effect of Eruca sativa extract
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  • Journal title : Korean Journal of Food Preservation
  • Volume 23, Issue 1,  2016, pp.74-79
  • Publisher : The Korean Society of Food Preservation
  • DOI : 10.11002/kjfp.2016.23.1.74
 Title & Authors
Anti-melanogenic effect of Eruca sativa extract
Kim, Hyun-Soo;
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Eruca sativa (known as rocket plant) is a member of the Brassicaceae, which is considered an important chemo-preventive plant family. Although Eruca sativa has positive biological effects such as antioxidant and renal protective activities, the effect of the Eruca sativa extract as a therapeutic agent for skin whitening has not been reported. In this study, we investigated the applicability of the extract of Eruca sativa as a functional materials by examining the its physiological activities. The Eruca sativa extract showed low cytotoxicity against murine melanoma B16F10 cells. At concentrations (below 100 mg/L) that showed none or little cytotoxicity, the Eruca sativa extract showed high DPPH radical scavenging activity (ID50, 17.60 mg/L). In addition, the Eruca sativa extract inhibited tyrosinase activity (, 132.54 mg/L) and decreased melanin content (, 158.90 mg/L). Finally, the treatment with the Eruca sativa extract suppressed the protein expression of tyrosinase in a concentration-dependent manner. These findings suggested that the Eruca sativa extract inhibited melanin synthesis by not only suppressing intracellular tyrosinase expression but also directly inhibiting tyrosinase activity. Therefore, these results indicate that the Eruca sativa extract may be an effective material for functional cosmetics such as skin whitening materials.
Eruca sativa;melanin;tyrosinase;
 Cited by
초미세 분쇄한 삼백초(Saurus chinensis) 추출물의 미용 활성,박혜진;박기태;홍신협;김나현;박미정;홍은진;안동현;안봉전;조영제;

한국식품저장유통학회지, 2016. vol.23. 6, pp.899-905 crossref(new window)
Sohn ES, Kim SW, Kang JS, Lee SP (2004) Technology trend patent information analysis of cosmetic materials derived from natural products. Appl Chem, 8, 466-469

Hill HZ, Li W, Xin P, Michell DL (1997) Melanin: a two edged sword?. Pigment Cell Res, 10, 158-161 crossref(new window)

Kobayashi T, Urabe K, Winder AJ, Jimenez-Cervantes C, Imokawa G, Brewington T, Solano F, Garcia-Borron JC, Hearing VJ (1994) Tyrosinase related protein-1 (TRP-1) function as a DHICA oxidase in melanin biosynthesis. EMBO J, 3, 5818-5825

Briganti S, Camera E, Picardo M (2003) Chemical and instrumental approaches to treat hyperpigmentation. Pigment Cell Res, 16, 101-110 crossref(new window)

Lamy E, Schroder J, Paulus S, Brenk P, Stahl T, Mersch-Sundermann V (2008) Antigenotoxic properties of Eruca sativa (rocket plant), erucin and erysolin in human hepatoma (HepG2) cells towards benzo(a)pyrene and their mode of action. Food Chem Toxicol, 46, 2415-2421 crossref(new window)

Sarwar Alam M, Kaur G, Jabbar Z, Javed K, Athar M (2007) Eruca sativa seeds possess antioxidant activity and exert a protective effect on mercuric chloride induced renal toxicity. Food Chem Toxicol, 45, 910-920 crossref(new window)

Ranke J, Molter K, Stock F, Bottin-Weber U, Poczobutt J, Hoffmann J, Ondruschka B, Filser J, Jastorff B (2004) Biological effects of imidazolium ionic liquids with varying chain lengths in acute Vibrio fischeri and WST-1 cell viability assays. Ecotoxicol Environ Saf, 58, 396-404 crossref(new window)

Miliauskas G, Venskutonis PR, van Beek TA (2004) Screening of radical scavenging activity of some medicinal and aromatic plant extracts. Food Chem, 85, 231-237 crossref(new window)

Masamoto Y, Ando H, Murata Y, Shimoishi Y, Tada M, Takahata K (2003) Mushroom tyrosinase inhibitory activity of esculetin isolated from seeds of Euphorbia lathyris L. Biosci Biotechnol Biochem, 67, 631-634 crossref(new window)

Hosoi J, Abe E, Suda T, Kuroki T (1985) Regulation of melanin synthesis of B16 mouse melanoma cells by 1 alpha, 25-dihydroxyvitamin D3 and retinoic acid. Cancer Res, 45, 1474-1478

Jeon YS, Jung YJ, Youm JK, Kim YK, Kim SN (2013) Inhibitory effect of Endarachne binghamiae extract on melanin synthesis. Korean J Plant Res, 26, 526-532 crossref(new window)

Kim TH, You JK, Kim JM, Baek JM, Kim HS, Park JH, Choe M (2010) Antioxidant and whitening effects of Sorbus commixta HEDL cortex extract. J Korean Soc Food Sci Nutr, 39, 1418-1424 crossref(new window)

Song HS, Moon HJ, Park BE, Choi BS, Lee DJ, Lee JY, Kim CJ, Sim SS (2007) Anti-oxidant activity and whitening activity of bamboo extracts. J Pharm Soc, 51, 500-507

Kim JS, Kim JW, Kwon HS, Lim HW, Lee HY (2013) Screening of skin whitening activity of Codonopsis lanceolata extract by complex streaming process. Korean J Med Crop Sci, 21, 54-60 crossref(new window)