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Protective effect of STAR of STAR series on CCl4 induced acute hepatotoxicity by regulation of reactive oxygen species
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  • Journal title : Korean Journal of Food Preservation
  • Volume 23, Issue 2,  2016, pp.275-282
  • Publisher : The Korean Society of Food Preservation
  • DOI : 10.11002/kjfp.2016.23.2.275
 Title & Authors
Protective effect of STAR of STAR series on CCl4 induced acute hepatotoxicity by regulation of reactive oxygen species
Chang, Bo Yoon; Oh, Jun Seok; Han, Ji Hye; Kim, Da Eun; Hong, Jae Heoi; Kim, Sung Yeon;
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STAR of STAR (SS 01-04) is a series of drinks that consist of various extracts obtained from Coriolus versicolor, Artemisia capillaris Thunb., Hovenia dulcis, Acanthopanax sessiliflorus, Lycium chinense, Citrus reticulata, Saururus chinensis, Pueraria lobata, Pyrus pyrifolia, and Oenanthe javanica. A purpose of this study was to investigate the hepatoprotective effect of SS 01-04. Antioxidant activity of the drinks was evaluated by conducting a hydroxyl radical-scavenging assay. Cytotoxicity and hepatoprotective potential were determined using HepG2 cells in vitro, while protective effects against acute hepatotoxicity was evaluated in vivo. The antioxidant activity of the SS 01-04 at concentration of 100 and 250 mg/mL was similar to that of vitamin C. tert-Butyl hydroperoxide (tBHP)-induced production of reactive oxygen species (ROS) was blocked by SS 01, 03 and 04 in a dose-dependent manner. Treatment with SS 04 significantly lowered the serum levels of alanine aminotransferase and aspartate aminotransferase in an animal model of carbon tetrachloride hepatotoxicity (p<0.05). In addition, SS04 increased glutathione level while decreased malondialdehyde level in the liver considerably (p<0.05). It also inhibited the increase in the levels of triglyceride and cholesterol in serum and the liver. These findings indicated that SS 01-04 possessed antioxidant activity and protect against ROS. In particular, SS 04 is potentially highly beneficial in treating liver damage as it scavenges reactive free radicals and boosts the endogenous antioxidant system.
Herb mtixure;Antioxidant;Hepatoprotection;Star of Star;
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Yeon SH, Ham H, Sung JH, Kim YH, Namkoong SG, Jeong HS, Lee JS (2013) Antioxidant activities of hot water extract from cornus walteri wanger against oxidative stress induced by tert-butyl hydroperoxide in HepG2 Cells. J Korean Soc Food Sci Nutr, 42, 1525-1532 crossref(new window)

Ghneim HK, Alshebly MM (2016) Biochemical markers of oxidative stress in saudi women with recurrent miscarriage. J Korean Med Sci, 31, 98-105 crossref(new window)

Mourao Mde M, Dinguirard N, Franco GR, Yoshino TP (2009) Role of the endogenous antioxidant system in the protection of Schistosoma mansoni primary sporocysts against exogenous oxidative stress. PLoS Negl Trop Dis, 17, 550-562

Jin X, Cong T, Zhao L, Ma L, Li R, Zhao P, Guo C (2015) The protective effects of Masson pine pollen aqueous extract on $CCl_4$-induced oxidative damage of human hepatic cells. Int J Clin Exp Med, 8, 17773-17780

de Andrade KQ, Moura FA, Dos Santos JM, de Arajo OR, de Farias Santos JC, Goulart MO (2015) Oxidative stress and inflammation in hepatic diseases: therapeutic possibilities of N-Acetylcysteine. Int J Mol Sci, 37, 30269-30308

Jiang JX, Torok NJ (2014) NADPH oxidases in chronic liver diseases. Adv Hepatol, 2014, 742931

Korenaga M, Hidaka I, Nishina S, Sakai A, Shinozaki A, Gondo T, Furutani T, Kawano H, Sakaida I, Hino K (2011) A glycyrrhizin-containing preparation reduces hepatic steatosis induced by hepatitis C virus protein and iron in mice. Liver Int, 31, 552-560 crossref(new window)

Chen Y, Krishan M, Nebert DW, Shertzer HG (2012) Glutathione-deficient mice are susceptible to TCDDInduced hepatocellular toxicity but resistant to steatosis. Chem Res Toxicol, 25, 94-100 crossref(new window)

Chon JW, Kweon HY, Jo YY, Yeo JH, Lee HS (2012) Protective effects of extracts of Protaetia brevitarsis on carbon tetrachloride-induced hepatotoxicity in the mice. J Seric Entomol Sci, 50, 93-100

Park SM, Ki SH, Han NR, Cho IJ, Ku SK, Kim SC, Zhao RJ, Kim YW (2015) Tacrine, an oral acetylcholinesterase inhibitor, induced hepatic oxidative damage, which was blocked by liquiritigenin through GSK3-beta inhibition. Biol Pharm Bull, 38, 184-192 crossref(new window)

Stamatinos K, Pierris N (2013) Serenoa repens extract additionally to quinolones in the treatment of chronic bacterial prostatitis. The preliminary results of a long term observational study. Arch Ital Urol Androl, 84, 190-196

Gulan Z Xinghui H, Jian Y, Yonghong W, Zhanzhuang T (2015) Effect of nourishing “Yin” removing “Fire” chinese herbal mixture on hypothalamic mammalian target of rapamycin expression during onset of puberty in female rats. Evid Based Complement Alternat Med, 2015, 157846

Bansky D, Barolet R (1990) Chinese herbal medicine formulas and strategies. Eastland Press, Seattle, WA, USA, p 7-8

Lee SG, Jeong HJ, Lee EJ, Kim JB, Choi SW (2011) Antioxidant and anti-inflammatory activities of ethanol extracts from medicinal herb mixtures. Korean J Food Sci Technol, 43, 200-205 crossref(new window)

Ko JB (2005) Effects of liquid culture of Coriolus versicolor on lipid metabolism and enzyme activities in rats fed cholesterol diet, J Life Sci, 15, 790-795 crossref(new window)

Choi JY, Kim JH, Kim G, Kim CK, Choi MS (2014) Effect of fermented Hovenia dulcis Thunb fruit water extract on biomarker for liver injury and body weight changes in rats given oral administration of ethanol. Korean J Food Preserv, 21, 412-420 crossref(new window)

Yu KH, Lee SY, Yang HM, Ham YA, Lee SU, Chae SW, Lee YJ (2013) Effects of the Artemisia capillaris Extract on the Hepatotoxicity in Ethanol-induced Rats. J Korean Soc Food Sci Nutr, 42, 1560-1566 crossref(new window)

Par YS (2010) Antioxidant efeects and improvement of lipid metabolism of acathopanacis cortes water extract in rats fed high fat diet. J East Asian Soc Dietary Life, 20, 37-45

Yoon JS, Cha YJ, Kim JS (2008) The effects of lycii fructus and lycii folium on the liver in ovariectomized rat. Korean J Microscopy, 38, 353-361

Ko BS, Jang JS, Hong SM, Kim DW, Sung SR, Prak HR, Lee JE, Jeon WK, Park SM (2006) Effect of new remedies mainly comprised of hovenia dulcis thunb on alcohol degradation and liver protection in sprague dawley male rats. J Korean Soc Food Sci Nutr, 35, 828-834 crossref(new window)

Ha BJ, Ha JM, Lee SH, Lee JY, Park SY (2003) Protective effects of saururus chinensis baill extracts on liver cell. J Food Hyg Safety, 18, 177-182

Lee E, Shin CO (2007) Effects of galgeun (Pueraria radix) extracts on plasma and liver lipid composition, liver function and antioxidative capacity in rats fed high oxidized Fat. Korean J Plant Res, 20, 475-480

Valcheva-Kuzmanova S, Borisova P, Galunska B, Krasnaliev I, Belcheva A. (2004) Hepatoprotective effect of the natural fruit juice from Aronia melanocarpa on carbon tetrachloride-induced acute liver damage in rats. Exp Toxicol Pathol, 56, 195-201 crossref(new window)

Jeong YY, Lee YJ, Lee KM, Kim JY (2009) The effects of Oenanthe javanica Extracts on hepatic gat accumulation and plasma biochemical profiles in a nonalcoholic fatty liver disease model. J Korean Soc Appl Biol Chem, 52, 632-367 crossref(new window)

Klouwen HM (1962) Determination of the sulfhydryl content of thymus and liver using DPPH. Archives of biochemistry and biophysics, 99, 116-120 crossref(new window)

Rertman S, Frankel S (1957) A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am J Clin Pathol, 28, 56-63 crossref(new window)

Griffith OW, Meister A (1979) Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine). The Journal of biological chemistry, 254, 7558-7560

Draper HH, Hadley M (1990) Malondialdehyde determination as index of lipid peroxidation. Methods in enzymology, 186, 421-431 crossref(new window)

Al-Sayed E, Esmat A (2016) Hepatoprotective and antioxidant effect of ellagitannins and galloyl esters isolated from Melaleuca styphelioides on carbon tetrachloride-induced hepatotoxicity in HepG2 cells. Pharm Biol, 5, 1-9

Noh JR, Gang GT, Kim YH, Yang KJ, Hwang JH, Lee HS, Oh WK, Song KS, Lee CH (2010) Antioxidant effects of the chestnut (Castanea crenata) inner shell extract in t-BHP-treated HepG2 cells, and $CCl_4^-$ and high-fat diet-treated mice. Food Chem Toxicol, 48, 3177-3183 crossref(new window)

Linhart K, Bartsch H, Seitz HK (2014) The role of reactive oxygen species (ROS) and cytochrome P-450 2E1 in the generation of carcinogenic etheno-DNA adducts. Redox Biology, 3, 56-62 crossref(new window)

Rivera H, Shibayama M, Tsutsumi V, Perez-Alvarez V, Muriel P (2008) Resveratrol and trimethylated resveratrol protect from acute liver damage induced by $CCl_4$ in the rat. J Appl Toxicol, 28, 147-155 crossref(new window)

Ganaie MA, Khan TH, Siddiqui NA, Ansari MN (2015) Ameliorative effect of methanol extract of Rumex vesicarius on $CCl_4$-induced liver damage in Wistar albino rats. Pharmaceutical Biology, 53, 1163-1167 crossref(new window)

Gad AS, Khadrawy YA, El-Nekeety AA, Mohamed SR, Hassan NS, Abdel-Wahhab MA (2011) Antioxidant activity and hepatoprotective effects of whey protein and Spirulina in rats. Nutrition, 27, 582-589 crossref(new window)

Jin YX, Yoo YS, Han EK, Kang IJ, Chung CK (2008) Artemisia capillaris and Paecilomyces japonica stimulate lipid metabolism and reduce hepatotoxicity induced by carbon tetrachloride in rats. J Korean Soc Food Sci Nutr, 37, 548-554 crossref(new window)