JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Inhibitory effect of Capparis zeylanica Linn. on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
  • Journal title : TANG [HUMANITAS MEDICINE]
  • Volume 2, Issue 2,  2012, pp.19.1-19.6
  • Publisher : Association of Humanitas Medicine
  • DOI : 10.5667/tang.2012.0008
 Title & Authors
Inhibitory effect of Capparis zeylanica Linn. on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia
Chaudhary, Amrendra Kumar; Solanki, Ruchi; Singh, Vandana; Singh, Umesh Kumar;
  PDF(new window)
 Abstract
Linn. a 'Rasayana' drug is used for its memory enhancing effects in the traditional Ayurvedic system of medicine. The aim of this study was to evaluate acetylcholinesterase (AChE) inhibitory and memory enhancing activities of Linn. The and models of AChE inhibitory activity were used along with Morris water maze test to study the effect on memory in rats. The anticholinesterase effect of methanolic and aqueous extracts of was measured by spectrophotometric Ellman method at 0.1, 0.3, 1.0, 3.0, 10 and 30 mg/ml and brain monoamine oxidase (MAO-A and MAO-B) activity was assessed by Naoi's method. The results and AChE assay revealed that methanolic and aqueous extracts of inhibit AChE activity, whereas these extracts did not alter MAO activity at any concentration tested as compared to moclobemide and L-deprenyl. The results indicate that improves scopolamine-induced memory deficits through inhibition of AChE activity, and not by direct MAO inhibition.
 Keywords
Capparis zeylanica Linn;Rasayana drug;anticholinesterase;MAO activity;amnesia;scopolamine;
 Language
English
 Cited by
 References
1.
Ahemed T, Gilani AH. Inhibitory effects of curcuminoids on acetylcholineestrase activity and attenuation of scopolamine-induced amnesia may explain medical use of turmuric in Alzheimer's disease. Pharmacol Biochem Behav. 2009;91:554-559. crossref(new window)

2.
Agarwal SS, Talele GS. Free radical scavenging activity of Capparis zeylanica. Med Plants - Int J Phytomed Related Ind. 2009;1:2.

3.
Chaudhary SR, Chavan MJ, Gaud RS. Anti-inflammatory and analgesic activity of Capparis zeylanica root extracts. Indian J Nat Prod. 2004;20:36-39.

4.
Chopra RN. Glossary of Indian Medicinal Plants. (New Delhi, India: Council of Scientific and Industrial Research), p. 49, 1969.

5.
Chopade VV, Tankar AN, Ganjiwale RO, Yeole PG. Antimicrobial activity of Capparis zeylanica Linn. Roots. Int J Green Pharm. 2008;2:28-30. crossref(new window)

6.
Drachman DA, Leavitt J. Human memory and cholinergic system. Arch Neurobiol. 1974; 30:13-21.

7.
Ellman GL, Courtney KD, Andres V, Featherstone RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol. 1961;7:88-95. crossref(new window)

8.
Everitt BJ, Robbins TW. Central cholinergic system and cognition. Annu Rev Psychol. 1997;48:649-684. crossref(new window)

9.
Govindrajan R, Kumar VM, Pushpangandan P. Antioxidant approach to disease management and role of 'Rasayana' herbs of Ayurveda. J Ethanopharmacol. 2005;99:165-178. crossref(new window)

10.
Ghule BV, Murugananthan G, Nakhat PD, Yeole PG. Immunostimulant effects of Capparis zeylanica leaves. J Ethanopharmacol. 2006;108:311-315. crossref(new window)

11.
Ghule BV, Murugananthan G, Yeole PG. Analgesic antipyretic effects of Capparis zeylanica leaves. Fitoterapia. 2007;78:365-369. crossref(new window)

12.
Haque M, Haque ME, Rahman MM, Rahman MM, Khondkar P, Wahed MI, Mossadik MA, Gray AI, Sarker SD. E-octadec-7-en-5-ynoic acid from the roots of Capparis zeylanica. Fitoterapia. 2004;75:130-133. crossref(new window)

13.
Khandelwal KR. Practical Pharmacognosy. 11th ed. (Pune, India: Nirali Prakashan), pp. 149-156, 2004.

14.
Kirtikar KR, Basu BD. Indian Medicinal Plants. 2nd ed. (Dehradun, India: Oriental Enterprises), pp. 200-201, 1987.

15.
Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem. 1951;193:265-275.

16.
Megazzini P, Bernardi G, Balloti P. Regional changes of the cholinergic system in the guinea-pig's brain after physostigmine. Experientia. 1965;21:406-408. crossref(new window)

17.
Mishra SN, Tomar PC, Lakra N. Medicinal and food values of Capparis-a harsh terrian plant. Indian J Traditional Knowledge. 2007;6:230-238.

18.
Mahmood C, Daulatabad JD, Desai VA, Hosamani KM. New source of oil with novel fatty acids for industrial utilization. Ind Eng Chem Res. 1991;30:2596-2598. crossref(new window)

19.
Mu L, Kou J, Zhu D, Yu B. Comparison of neuroprotective effects of flavonoids, terpenoids, and their combinations from Ginkgo biloba on ischemia-reperfusion-injured mice. Pharm Biol. 2007;45(9):728-733. crossref(new window)

20.
Nag M, Nandy N. Serotonin and benzylamine oxidation by type A and B MAO of rat brain in presence of organophosphate pesticides. Indian J Exp Biol. 2001;39:802-806.

21.
Naoi M, Nagatsu T. Quinoline and quininaldines as naturally occurring inhibitors specific for type A monoamine oxidase. Life Sci. 1987;40:1075-1082. crossref(new window)

22.
Orhan I, Aslan M. Appraisal of scopolamine-induced antiamnesic effect in mice and in vitro antiacetylcholinesterase and antioxidant activities of some traditionally used Lamiaceae plants. J Ethnopharmacol. 2009;122:327-332. crossref(new window)

23.
Puri HS. 'Rasayana'-Ayurvedic herbs for longevity and rejuvenation. (London, United Kingdom: Taylor and Francis), p. 25, 2003.

24.
Ro JS, Lee KS, Lee MK. Inhibition of type A monoamine oxidase by coptisine in mouse brain. Life Sci. 2001;70:639-645. crossref(new window)

25.
Satyanarayan T, Mathews AA, Vijeta P. Phytochemical and pharmacological review of some Indian Capparis species. Pharmacogn Rev. 2008;2:36-45.

26.
Sharaf MA. Flavonoids of four Cleome and three Capparis species. Biochem Syst Ecol. 1997;25:161-166. crossref(new window)

27.
Solanki R, Chaudhary AK, Singh R. Effect of leaf extract of Capparis zeylanica Linn. on spatial learning and memory in rats. J Nat Med. 2012; Jan 20. [Epub ahead of print]

28.
Upaganlawar AB, Chopade VV, Ghule BV, et al. Analgesic effects of methanolic extract of Capparis zeylanica Linn. roots. Pharmacogn Mag. 2008;4:112-114.

29.
Woo HI, Seong SH, Seon AL, Xiang HH, Kyong SL, Myung KL, Bang YH, Jai SR. Monoamine oxidase inhibitory napthoquinones from Lithospermum erythrorhizon. Arch Pharm Res. 2005;28:400-404. crossref(new window)

30.
Yavich L, Sirvio J, Heinenen E, Riekkinen P. The interaction of L-deprenyl and scopolamine on spatial learning/memory in rats. J Neural Transm-Park. 1993;6(3):189-197. crossref(new window)