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Immunomodulatory properties of medicinal maggots Lucilia sericata in wound healing process
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  • Journal title : TANG [HUMANITAS MEDICINE]
  • Volume 2, Issue 3,  2012, pp.23.1-23.7
  • Publisher : Association of Humanitas Medicine
  • DOI : 10.5667/tang.2012.0025
 Title & Authors
Immunomodulatory properties of medicinal maggots Lucilia sericata in wound healing process
Bohova, Jana; Majtan, Juraj; Takac, Peter;
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 Abstract
The healing properties of medicinal maggots (larval stage of Lucilia sericata) are widely used in the chirurgical debridement of non-healing wounds including diabetic foot ulcers, venous and pressure ulcers, where classical approaches have failed. Several kinds of wounds are prone to complications coming out of a specific wound bed environment. There are multi-resistant bacterial species present, their pathogenic impact is multiplied by their ability to form a biofilm. Moreover, immunological events in chronic wounds differ from those in acute wounds. Non-healing wounds are cycled in the early inflammation phase with increased levels of inflammation attributes like inflammation cytokines and matrix metalloproteinases produced by inflammation phase cells. Application of larval therapy promotes progress in the healing process to the next stages involving tissue granulation and re-epithelisation. Larval debridement is an effective method of cleaning the wound of cell debris, necrotic tissue and bacterial load. This happens in a mechanical and biological manner, but the whole complex mechanism of the maggot healing activity is still not fully elucidated. Centuries of clinical practice brings noticeable proof of the maggots' beneficial effect in wound healing management. This long history led to the investigation of the bioactive components of the larval body and its extracts in vitro. We introduce a review which describes the immunomodulation impact of maggot body components on the cellular and molecular levels of the wound healing process.
 Keywords
wound healing;Lucilia;maggot debridement therapy;
 Language
English
 Cited by
1.
Network Analysis of MPO and Other Relevant Proteins Involved in Diabetic Foot Ulcer and Other Diabetic Complications, Interdisciplinary Sciences: Computational Life Sciences, 2017  crossref(new windwow)
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