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Role of Curcuma longa, a traditional ayurvedic medicinal plant, in diabetes
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  • Journal title : TANG [HUMANITAS MEDICINE]
  • Volume 2, Issue 4,  2012, pp.31.1-31.7
  • Publisher : Association of Humanitas Medicine
  • DOI : 10.5667/tang.2012.0032
 Title & Authors
Role of Curcuma longa, a traditional ayurvedic medicinal plant, in diabetes
Ponnusamy, Sudha; Zinjarde, Smita; Bhargava, Shobha; Kumara, Ameeta Ravi;
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Curcuma longa belongs to the family Zingiberaceae and can be found in the tropical and subtropical regions of the world. It is widely used in Asiatic countries, especially India and South East Asia where it is cultivated commercially as a condiment. Its rhizomes exhibit anti-inflammatory, anti-human immunodeficiency virus, anti-bacterial, antioxidant effects, nematocidal activities, antiproliferative and antiangiogenic activities and are of pharmaceutical importance. Another relevant medicinal property exhibited by it is antidiabetic property which is reviewed here. Studies on the efficacy of crude C.longa extracts against type 2 diabetes in murine models reveal that it demonstrates a hypoglycemic effect by lowering the blood glucose levels under in vivo conditions. Clinical studies have revealed the safety of curucmin (major principle component exhibiting pharmaceutical properties from C.longa) on humans but with very low bioavailability. In view of its effective hypoglycemic effect and its low bioavailability, further studies are needed for the characterization of the bioactive principles and formulating the development of C.longa extracts as a novel anti-diabetic therapeutic agent.
Curcuma longa;diabetes mellitus;curcuminoids;curcuminoid derivatives;glycosidases;
 Cited by
Potential of some traditionally used edible plants for prevention and cure of diabesity associated comorbidities,;;;;;

탕, 2015. vol.5. 2, pp.8.1-8.22 crossref(new window)
Akram M, Uddin S, Ahmed A, Usmanghani K, Hannan A, Mohiuddin E, Asif M. Curcuma longa and curcumin: a review article. Rom J Biol-Plant Biol. 2010;55:65-70.

Ammon HP, Wahl MA. Pharmacology of Curcuma longa. Planta Med. 1991;57:1-7. crossref(new window)

Ammon HP, Anazodo MI, Safayhi H, Dhawan BN, Srimal RC. Curcumin: a potent inhibitor of leukotriene B4 formation in rat peritoneal polymorphonuclear neutrophils (PMPL). Planta Med. 1992;58:226. crossref(new window)

Ammon HP, Wahl MA. Pharmacology of Curcuma longa. Planta Med. 1991;57:1-7. crossref(new window)

Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. Bioavailability of Curcumin: problems and promises. Mol Pharmaceutics. 2007;4:807-818. crossref(new window)

Anand P, Thomas SG, Kunnumakkara AB, Sundaram C, Harikumar KB, Sung B, Tharakan ST, Misra K, Priyadarsini IK, Rajasekharan KN, Aggarwal, BB. Biological activities of curcumin and its analogues (Congeners) made by man and mother nature. Biocheml Pharmacol. 2008;76:1590-1611. crossref(new window)

Anto RJ, Kuttan G, Babu KVD, Rajasekharan KN, Kuttan R. Antitumor and antioxidant activity of natural curcuminoids. Cancer Lett. 1995;94:79-83. crossref(new window)

Anto RJ, Kuttan G, Babu KVD, Rajasekharan KN, Kuttan R. Anti-inflammatory activity of natural and synthetic curcuminoids. Pharm Pharmacol Commun. 1998;4:103-106.

Araujo CAC, Leon LL. Biological activities of Curcuma longa L. Mem Inst Oswaldo Cruz, Rio de Janeiro. 2001;96:723-728. crossref(new window)

Arun N, Nalini N. Efficacy of turmeric on blood sugar and polyol pathway in diabetic albino rats. Plant Foods Hum Nutr. 2002;57:41-52. crossref(new window)

Balasubramanyam M, Koteswari AA, Kumar SR, Monickaraj SF, Maheswari JU Mohan V. Curcumin-induced inhibition of cellular reactive oxygen species generation: novel therapeutic implications. J Biosci. 2003;28:715-72. crossref(new window)

Cheng AYY, Fantus IG. Oral antihyperglycemic therapy for type 2 diabetes mellitus. CMAJ. 2005;175:213-226.

Chiu J, Khan ZA, Farhangkhoee H, Chakrabarti S. Curcumin prevents diabetes-associated abnormalities in the kidneys by inhibiting p300 and nuclear factor-$\kappa B$. Nutrition. 2009;25:964-972. crossref(new window)

Cikrikci S, Mozioglu E, Yılmaz, H. Biological activity of curcuminoids isolated from Curcuma longa. Rec Nat Prod. 2008;2:19-24.

Du Z, Liu R, Shao W, Mao X, Ma L, Gu L, Huang Z, Chan, ASC. $\alpha$-Glucosidase inhibition of natural curcuminoids and curcumin analogs. Eur J Med Chem. 2006;41:213-218. crossref(new window)

Gandhi P, Khan Z, Chakraverty N. Soluble curcumin: a promising oral supplement for health management. Int J Appl Biol Pharmaceut Tech. 2011;1:1-7.

Grover JK, Yadav S, Vats, V. Medicinal plants of India with anti-diabetic potential. J Ethnopharmacol. 2002;81:81-100. crossref(new window)

Jain SK, Rains J, Croad J, Larson B, Jones K. Curcumin supplementation lowers TNF-$\alpha$, IL-6, IL-8, and MCP-1 Secretion in high glucose-treated cultured monocytes and blood levels of TNF-$\alpha$, IL-6, MCP-1, glucose, and glycosylated hemoglobin in diabetic rats. Antioxidants & Redox Signaling. 2009;11:241-249. crossref(new window)

Kuroda M, Mimaki Y, Nishiyama T, Mae T, Kishida H, Tsukagawa M, Takahashi K, Kawada T, Nakagawa K, Kitahara M. Hypoglycemic effects of turmeric (Curcuma longa L. rhizomes) on genetically diabetic KK-Ay mice. Biol Pharm Bull. 2005;28:937-939. crossref(new window)

Kuttan R, Bhanumathy P, Nirmala K, George MC. Potential anticancer activity of turmeric (Curcuma longa). Cancer Lett. 1985;29:197-202. crossref(new window)

Lekshmi PC, Arimboor R, Raghu KG, Menon AN. Turmerin, the antioxidant protein from turmeric (Curcuma longa) exhibits antihyperglycaemic effects. Nat Prod Res. 2011;Oct 6. [Epub ahead of print].

Lekshmi PC, Arimboor R, Indulekha PS, Menon AN. Turmeric (Curcuma longa L.) volatile oil inhibits key enzymes linked to type 2 diabetes. Int J Food Sci Nutr. 2012;Mar 5. [Epub ahead of print].

Luna B, Pharm D, Feinglos MN. Oral agents in the management of type 2 diabetes mellitus. Am Fam Physician. 2001;63:1747-1756.

Maheshwari RK, Singh AK, Gaddipati J, Srimal RC. Multiple biological activities of curcumin: A short review. Life Sci. 2006;78:2081-2087. crossref(new window)

Nishiyama T, Mae T, Kishida H, Tsukagawa M, mimaki Y, Kuroda M, Sashida Y, Takahashi K, Kawada T, Nakagawa K, Kitahara, M. Curcuminoids and sesquiterpenoids in turmeric (Curcuma longa L.) suppress an increase in blood glucose level in type 2 diabetic KK-Ay mice. J Agric Food Chem. 2005;53:959-963. crossref(new window)

Pari L, Murugan P. Changes in glycoprotein components in streptozotocin--nicotinamide induced type 2 diabetes: influence of tetrahydrocurcumin from Curcuma longa. Plant Foods Hum Nutr. 2007;62:25-29. crossref(new window)

Petnual P, Sangvanich P, Karnchanatat A. A lectin from the rhizomes of turmeric (Curcuma longa L.) and its antifungal, antibacterial, and $\alpha$-glucosidase inhibitory activities. Food Sci Biotechnol. 2010;19:907-916. crossref(new window)

Ramsewak RS, DeWitt DL, Nair MG. Cytotoxicity, antioxidant and anti-inflammatory activities of curcumins I-III from Curcuma longa. Phytomedicine. 2000;7:303-308. crossref(new window)

Roth GN, Chandra A, Nair MG. Novel bioactivities of Curcuma longa constituents. J Nat Prod. 1998;61:542-545. crossref(new window)

Roughley PJ, Whiting DA. Experiments in the biosynthesis of curcumin. J Chem Soc. 1973;20:2379-2388.

Sandur SK, Pandey MK, Sung B, Ahn KS, Murakami A, Sethi G, Limtrakul P, Badmaev V, Aggarwal BB. Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. Carcinogenesis. 2007;28:1765-1773. crossref(new window)

Selvam R, Subramanian L, Gayathri R, Angayarkanni N. The anti-oxidant activity of turmeric (Curcuma longa). J Ethnopharmacol. 1995;47:59-67. crossref(new window)

Sharma S, Kulkarni SK, Chopra K. Curcumin, the active principle of turmeric (curcuma longa), ameliorates diabetic nephropathy in rats. Clin Exp Pharmacol Physiol. 2006;33:940-945. crossref(new window)

Shishodia S, Sethi G, Aggarwal BB. Curcumin: getting back to the roots. Ann NY. Acad Sci. 2005;1056:206-217. crossref(new window)

Sivabalan S, Anuradha CV. A comparative study on the antioxidant and glucose-lowering effects of curcumin and bisdemethoxycurcumin analog through in vitro assays. Int J Pharmacol. 2010;6:664-669. crossref(new window)

Srinivasan K. Plant foods in the management of diabetes mellitus: spices as beneficial antidiabetic food adjuncts. Int J Food Sci Nutr. 2005;56:399-414. crossref(new window)

Srinivasan K, Ramarao P. Animal models in type 2 diabetes research: An overview. Indian J Med Res. 2007;125:451-472.

Srinivasan A, Menon VP, Periaswamy V, Rajasekaran K. Protection of pancreatic $\beta$-cell by the potential antioxidant bis-o-hydroxycinnamoyl methane, analogue of natural curcuminoid in experimental diabetes. J Pharm Pharmaceut Sci. 2003;6:327-333.

Sudha P, Ravindran R, Zinjarde S, Bhargava S, Kumar AR. Evaluation of traditional Indian antidiabetic medicinal plants for human pancreatic amylase inhibitory effect in vitro. Evid base Compl Alternative Med. 2011;2011:Article ID 515647,1-10.

Sudha P, Zinjarde S, Bhargava S, Rajamohanan PR, Kumar AR. Discovering Bisdemethoxycurcumin from Curcuma longa rhizome as a potent small molecule inhibitor of human pancreatic $\alpha$-amylase, a target for type-2 diabetes. Food Chem. 2012;135:2638-2642. crossref(new window)

Suresh BP, Srinivasan K. Influence of dietary curcumin and cholesterol on the progression of experimentally induced diabetes in albino rat. Mol Cell Biochem. 1995;152:13-21.

Suresh BP, Srinivasan K. Influence of dietary capsaicin and onion on the metabolic abnormalities associated with streptozotocin induced diabetes mellitus. Mol Cell Biochem. 1997;175:49-57. crossref(new window)

Suresh BP, Srinivasan K. Amelioration of renal lesions associated with diabetes by dietary curcumin in streptozotocin diabetic rats. Mol Cell Biochem. 1998;181:87-96. crossref(new window)

Usharani P Mateen AA, Naidu MUR, Raju YSN, Naval C. Effect of NCB-02, atorvastatin and placebo on endothelial function, oxidative stress and inflammatory markers in patients with type 2 diabetes mellitus: a randomized, parallel-group, placebo-controlled, 8-week study. Drugs R D. 2008;9:243-250. crossref(new window)

Verma S, Singh SP. Current and future status of herbal medicines. Vet World. 2008;1:347-350.

Wickenberg J, Ingemansson SL, Hlebowicz J. Effects of Curcuma longa (turmeric) on postprandial plasma glucose and insulin in healthy subjects. Nutr J. 2010;9:1-5. crossref(new window)

World Health Organization (WHO), Diabetes programme 2006, http//www.who.Int/diabetes/en/