JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Siphonochilus aethiopicus, a traditional remedy for the treatment of allergic asthma
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
  • Journal title : TANG [HUMANITAS MEDICINE]
  • Volume 3, Issue 1,  2013, pp.6.1-6.6
  • Publisher : Association of Humanitas Medicine
  • DOI : 10.5667/tang.2012.0040
 Title & Authors
Siphonochilus aethiopicus, a traditional remedy for the treatment of allergic asthma
Fouche, Gerda; van Rooyen, Schalk; Faleschini, Teresa;
  PDF(new window)
 Abstract
Asthma is a chronic inflammatory disease of the lungs, characterized by increased sensitivity to bronchoconstriction associated with infiltration of immune cells and mucus hyper secretion. In South Africa, the indigenous plant Siphonochilus aethiopicus, is used by traditional health practitioners to treat colds and flu, wheezing of the chest, coughs, influenza, sinus problems and mild asthma. In this study we aimed to investigate the potential anti-inflammatory and immune-modulating properties of S. aethiopicus in vitro. The dried and powdered S. aethiopicus plant material was extracted with organic solvents. The dried extracts were screened in vitro in the transcription response, NF- and a cytokine assay. Significant activity was observed for organic extracts of the plant in these assays. This study provides evidence that S. aethiopicus has anti-inflammatory and immune-suppressing properties in vitro. These findings may support anecdotal accounts of its effectiveness against allergic asthma.
 Keywords
Siphonochilus aethiopicus;Zingiberaceae;medicinal plants;asthma;allergies;herbal remedies;alternative treatment;
 Language
English
 Cited by
1.
The (2′S,7′S)-O-(2-methylbutanoyl)-columbianetin as a novel allergic rhinitis-control agent, Life Sciences, 2014, 98, 2, 103  crossref(new windwow)
 References
1.
Borel JF. History of the discovery of cyclosporine and of its early pharmacological development. Wien Klin Wochenschr. 2002;114:433-437.

2.
Boschetto P, Mapp CE, Picotti G, Fabbri LM. Neutrophils and asthma. Eur Respir J. 1989;6:456-459.

3.
Casale TB, Costa JJ, Galli SJ. TNF-alpha is important in human lung allergic reactions. Am J Resp Cell Mol. 1996;15:35-44. crossref(new window)

4.
Eichhorn T, Efferth T. P-glycoprotein and its inhibition in tumours by phytochemicals derived from Chinese herbs. J Ethnopharmacol. 2012;141:557-570. crossref(new window)

5.
Elliott CL, Allport VC, Loudon JAZ, Wu GD, Bennett PR. Nuclear factor-kappa B is essential for up-regulation of interleukin-8 expression in human amnion and cervical epithelial cells. Mol Hum Reprod. 2001;7:787-790. crossref(new window)

6.
Epstein FH, Barnes PJ, Karin M. Nuclear factor-${\kappa}B$-a pivotal transcription factor in chronic inflammatory diseases. New Engl J Med. 1997;336:1066-1071. crossref(new window)

7.
Faleschini MT, Myer MS, Harding N, Fouche G. Chemical profiling with cytokine stimulating investigations of Sutherlandia frutescens L. R. (Br.) (Fabaceae). South African Journal of Botany. 2013 [Epub ahead of print]

8.
Ghavami G, Sardari S, Ali Shokrgozar M. Cheminformatics-based selection and synergism of herbal extracts with anticancer agents on drug resistance tumor cells-ACHN and A2780/CP cell lines. Comput Biol Med. 2011;41:665-674. crossref(new window)

9.
Gibson PG, Simpson JL, Saltos N. Heterogeneity of airway inflammation in persistent asthma. Chest. 2001;119:1329-1336. crossref(new window)

10.
Grilli M, Chiu JJ, Lenardo MJ. NF-kappa B, and Rel: participants in a multiform transcriptional regulatory system. Int Rev Cytol. 1993;143:1-62. crossref(new window)

11.
Harada A, Sekido N, Akahoshi T, Wada T, Mukaida N Matsushima K. Essential involvement of interleukin-8 (IL-8) in acute inflammation. J Leukocyte Biol. 1994;56: 559-564.

12.
Jacobi HH, Poulsen LK, Reimert CM, Skov PS, Ulfgren AK, Jones I, Elfman LB, Malling HJ, Mygind N. IL-8 and the activation of eosinophils and neutrophils following nasal allergen challenge. Int Arch Allergy Immunol. 1998;116:53-59. crossref(new window)

13.
Khana MA, Singh M, Khan MS, Ahmad W, Najmi AK, Ahmad S. Alternative approach for mitigation of Doxorubicin-induced cardiotoxicity using herbal agents. Curr Clin Pharmacol. 2013. [Epub ahead of print]

14.
Karakurum M, Shreeniwas R, Chen J, Pinsky D, Yan SD, Anderson M, Sunouchi K, Major J, Hamilton T, Kuwabara K. Hypoxic induction of interleukin-8 gene expression in human endothelial cells. J Clin Invest. 1994;93:1564-1570. crossref(new window)

15.
Ko YC, Mukaida N, Ishiyama S, Tokue A, Kawai T, Matsushima K, Kasahara T. Elevated IL-8 level in the urine of patients with urinary tract infections. Infect Immun. 1993;61:1307-1314.

16.
Kulielka GL, Smith CW, LaRosa GJ, Manning AM, Mendoza LH, Daly TJ, Hughes BJ, Youker KA, Hawkins HK, Michael LH. Interleukin-8 gene induction in the myocardium after ischaemia and reperfusion in vivo. J Clin Invest. 1995;95:89-103. crossref(new window)

17.
Kunsch C, Rosen CA. NF-kappa B subunit-specific regulation of the interleukin-8 promoter. Mol Cell Biol. 1993;13:6137-6146.

18.
Lamblin C, Gosset P, Tillie-Leblond, I. Saulnier F, Marquette C, Wallaert B, Tonnel AB. Bronchial neutrophilia in patients with noninfectious status asthmaticus. Am J Respir Crit Care Med. 1998;157:394-402. crossref(new window)

19.
Lenardo MJ, Baltimaore D. NF-${\kappa}B$: a pleiotropic mediator of inducible and tissue specific gene control. Cell. 1989;58:227-229. crossref(new window)

20.
Liao F, Andalibi A, Qiao JH, Allayee H, Fogelman AM, Lusis AJ. Genetic evidence for a common pathway mediating oxidative stress, inflammatory gene induction, and aortic fatty streak formation in mice. J Clin Invest. 1994;94:877-884. crossref(new window)

21.
Lydyard P, Whelan A, Fanger M. BIOS Instant Notes: Immunology. 2nd ed. (New York: Taylor & Francis), 2004.

22.
MacDowell AL, Peters SP. Neutrophils in asthma. Curr Allergy Asthma Rep. 2007;7:464-468. crossref(new window)

23.
Manna SK, Ramesh GT. Interleukin-8 induces nuclear transcription factor-ΚB through a TRAF-6 dependent pathway. J Biol Chem. 2005;280:7010-7021. crossref(new window)

24.
Matsusaka T, Fujikawa K, Nishio Y, Mukaida N, Matsushima K, Akira S. Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8. Proc Natl Acad Sci U S A. 1993;90:10193-10197. crossref(new window)

25.
Mukaida N, Morita M, Ishikawa Y, Rice N, Okamoto S, Kasahara T, Matsushima K. Novel mechanism of glucocorticoid-mediated gene repression: nuclear factor-kappa B is target for glucocorticoid-mediated interleukin 8 gene repression. J Biol Chem. 1994;269:13289-13295.

26.
Muller S, Murillo R, Castro V, Brecht V, Merfort I. Sesquiterpene lactones from Montanoa hibiscifolia that inhibit the transcription factor NF-kappa B. J Nat Prod. 2004;67:622-630. crossref(new window)

27.
Nocker RE, Schoonbrood DF, van de Graaf EA, Hack CE, Lutter R, Jansen HM, Out TA. Interleukin-8 in airway inflammation in patients with asthma and chronic obstructive pulmonary disease. Int Arch Allergy Immunol. 1996;109:183-191. crossref(new window)

28.
O'Gorman MRG, Donnenberg AD. Handbook of Human Immunology. 2nd ed. (USA: CRC Press), 2008.

29.
Oliveira IC, Mukaida N, Matsushima K, Vilcek J. Transcriptional inhibition of the interleukin-8 gene by interferon is mediated by the NF-kappa B site. Mol Cell Biol. 1994;14:5300-5308.

30.
Parkin J, Cohen B. An overview of the immune system. Lancet. 2001;357: 1777-1789. crossref(new window)

31.
Raduner S, Majewska A, Chen JZ, Xie XQ, Hamon J, Faller B, Altmann KH, Gertsch J. Alkylamides from Echinacea are a new class of cannabinomimetics. J Biol Chem. 2006;281:14192-14206 crossref(new window)

32.
Saller R, Rostock M. Multimorbidity and multi-target therapy with herbal drugs. Praxis. 2012;101:1637-1642. crossref(new window)

33.
Sekido N, Mukaida N, Harada A, Nakanishi I, Watanabe Y, Matsushima K. Prevention of lung reperfusion injury in rabbits by a monoclonal antibody against interleukin-8. Nature. 1993;365:654-657. crossref(new window)

34.
Simone RE, Russo M, Catalano A, Monego G, Froehlich K, Boehm V, Palozza P. Lycopene inhibits NF-${\kappa}B$-mediated IL-8 expression and changes redox and PPAR${\gamma}$ signaling in cigarette smoke-stimulated macrophages. PLoS One. 2011;6:1-11.

35.
Smith HR, Larsen GL, Cherniack RM. Wenzel SE, Voelkel NF, Westcott JY, Bethel RA. Inflammatory cells and eicosanoid mediators in subjects with late asthmatic responses and increases in airway responsiveness. J Allergy Clin Immunol. 1992;89:1076-1084. crossref(new window)

36.
Spelman K, Burns JJ, Nichols D, Winters N, Ottersberg S, Tenborg M. Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators. Altern Med Rev. 2006;11:128-150.

37.
Sonoda Y, Kasahara T, Mukaida N, Shimizu N, Tomoda M, Takeda T. Stimulation of interleukin-8 production by acidic polysaccharides from the root of Panax ginseng. Immunopharmacology. 1997;38:287-294.

38.
Tapsell LC, Hemphill I, Cobiac L, Patch CS, Sullivan DR, Fenech M, Roodenrys S, Keogh JB, Clifton PM, Williams PG, Fazio VA, Inge KE. Health benefits of herbs and spices: the past, the present, the future. Med J Aust. 2006;185:S4-S24.

39.
Teran LM, Carroll M, Frew AJ. Montefort S, Lau LCK, Davies DE, Lindley I, Howarth PH, Church MK, Holgate ST. Neutrophil influx and interleukin-8 release after segmental allergen or saline challenge in asthmatics. Int Arch Allergy and Immunol. 1995;107:374-375. crossref(new window)

40.
Uluisik D, Keskin E. Effects of ginseng and echinacea on cytokine mRNA expression in rats. ScientificWorldJournal. 2012;2012:942025.

41.
Van Staden J. Ethnobotany in South Africa, J Ethnopharmacol. 2008;119:329-330. crossref(new window)

42.
Van Wyk B-E, Van Oudtshoorn B, Gericke N. Medicinal plants of South Africa. (South Africa: Briza Publ), 1997.

43.
Van Wyk B-E, Van Oudtshoorn B, Gericke N. Medicinal plants of South Africa. (Pretoria: Briza Publications), 2009.

44.
Yoshida A, Yoshida S, Khalil AK, Ishibashi T, Inomata H. Role of NF-kappaB-mediated interleukin-8 expression in intraocular neovascularization. Invest Ophthalmol Vis Sci. 1998;39:1097-1106.

45.
Zidek Z, Anzenbacher P, Kmonickova E. Current status and challenges of cytokine pharmacology. Brit J Pharmacol. 2009;157:342-361. crossref(new window)