Advanced SearchSearch Tips
Anticonvulsant potential of some medicinal plants and their beneficial properties
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
  • Journal title : TANG [HUMANITAS MEDICINE]
  • Volume 3, Issue 4,  2013, pp.27.1-27.13
  • Publisher : Association of Humanitas Medicine
  • DOI : 10.5667/tang.2013.0012
 Title & Authors
Anticonvulsant potential of some medicinal plants and their beneficial properties
Asif, Mohammad;
  PDF(new window)
Epilepsy has now become the most serious brain disorder. A number of synthetic antiepileptic drugs are available in practice, however their effectiveness does not grip true with the entire population suffering from epilepsy. Traditional systems of medicine are popular in developing countries and most of the population relies on traditional medicines for their primary health care need. Medicinal plants to be an important source of traditional medicines. Various plants are used for the treatment of epilepsy in traditional system of medicines and various plants are yet to be scientifically investigated. Phytoconstituents have been the basis of treatment of human diseases including epilepsy. Herbal products are extensively used for the treatment of many diseases worldwide and where allopathic fails or has severe side effects. Psycho neural drugs are also have very serious side effects like physical dependence, tolerance, deterioration of cognitive function and effect on respiratory, digestive and immune system. So the treatments through herbal medicines are widely used across the world due to their wide applicability and therapeutic efficacy with least side effects, which in turn has accelerated the research regarding natural therapy. In this review we have summarized some herbal antiepileptics.
anti epileptics;convulsions;herbs;side effects;
 Cited by
Achliya GS, Wadodkar SG, Dode AK. Evaluation of sedative and anticonvulsant activities of Unmadnashak ghrita. J Ethnopharmacol. 2004;94:77-83. crossref(new window)

AchIiya GS, Wadodkar SG, Dorley AK. Evaluation of CNS activity of Bramhi Ghrita. Ind J Pharmacol. 2005;37:33-36. crossref(new window)

Amabeoku GJ, Anticonvulsant activity of Nylandtia spinosa L. Dumont (Polygalaceae) aqueous and methanol leaf extracts in mice. Hum Exp Toxicol. 2008;27:811-818. crossref(new window)

Ambawade SD, Kasture VS, Kasture SB. Anticonvulsant activity of roots and rhizomes of Glycyrrhiza glabra. Indian J Pharmacol. 2002;34:251-255.

Amos S, Kolawole E, Akah P, Wambebe C, Gamaniel K. Behavioral effects of the aqueous extract of Guiera senegalensis in mice and rats. Phytomedicine. 2001;8:356-361. crossref(new window)

Arumugam S, Palanivelu A, Retnasamy G, Ramaiyan D. Study on the Antiseizure Activities of Inner Bark of Guettarda Speciosa (L.). Iran J Pharmacol & Therapeutics. 2009;8:73-76.

Bagheri SM, Sahebkar A, Gohari AR, Saeidnia S, Malmir M, Iranshahi M, Evaluation of cytotoxicity and anticonvulsant activity of some Iranian medicinal Ferula species. Pharm BioI. 2010;48:242-246. crossref(new window)

Balakrishnan S, Pandhi P, Bhargava VK. Effect of nimodipine on the efficacy of commonly used antiepileptic drugs in rats. Ind J Exp BioI. 1998;36:51-54.

Balamurugan G, Muralidharan P, Selvarajan S. Anti Epileptic Activity of Poly Herbal Extract from Indian Medicinal Plants. J Sci Res. 2009;1;153-159.

Barar FSK. Essentials of Pharmacotheraputics. (Newdelhi, India: Chand and Company Ltd. Publishers), 2000.

Bharal N, Sahaya K, Jain S, Mediratta PK, Sharma KK, Curcumin has anticonvulsant activity on increasing current electroshock seizures in mice. Phytother Res. 2008;22:1660-1664. crossref(new window)

Bialer M, Johannessen SI, Kupferberg HJ, Levy RH, Perucca E, Tomson T. Progress report on new antiepileptic drugs: a summary of the Seventh Eilat Conference (EILAT VII). Epilepsy Res. 2004;61:1-48. crossref(new window)

Bialer M. New antiepileptic drugs that are second generation to existing antiepileptic drugs. Expert Opin Investig Drugs. 2006;15:637-647. crossref(new window)

Bienvenu E, Amabeoku GJ, Eagles PK, Scott G, Springfield EP. Anticonvulsant activity of aqueous extract of Leonotis leonurus. Phytomedicine. 2002;9:217-223. crossref(new window)

Birbeck G, Chomba E, Atadzhanov M , Mbewe E , Haworth A. The social and economic impact of epilepsy in Zambia: a cross-sectional study. Lancet NeuroI. 2007;6:39-44. crossref(new window)

Bodhankar SL, Vyawahare NS. A Text book of Pathophysiology. (Pune, India: Nirali Prakashan), 2005.

Bopaiah CP, Pradhan N. Central nervous system stimulatory action from the root extract of Plumbago zeylanica in rats. Phytother Res. 2001;15:153-156. crossref(new window)

Bum EN, Taiwe GS, Nkainsa LA, Moto FC, Seke Etet PF, Hiana IR, Bailabar T, Rouyatou, Seyni P, Rakotonirina A, Rakotonirina SV, Validation of anticonvulsant and sedative activity of six medicinal plants. Epilepsy Behav. 2009;14:454-458. crossref(new window)

Bum EN, Schmutz M, Meyer C, Rakotonirina A, Bopelet M, Portet C, Jeker A, Rakotonirina SV, Olpe HR, Herrling P. Anticonvulsant properties of the methanolic extract of Cyperus articulatus (Cyperaceae). J EthnopharmacoI. 2001;76:145-150. crossref(new window)

Bum EN, Dawack DL, Schmutz M, Rakotonirina A, Rakotonirina SV, Portet C, Jeker A, Olpe HR, Herrling P. Anticonvulsant activity of Mimosa pudica decoction. Fitoterapia. 2004;75:309-314. crossref(new window)

Burkill HM. The Useful Plants of West Tropical Africa. 2nd ed. (Kew, UK Royal Botanical Garden), pp. 26-30, 2000.

Cambie RC, Ash J. Fijian Medicinal Plants. (Clayton South VIC, Australia: CSIRO), pp. 255, 1994.

Cardoso Vilela F, Soncini R, Giusti-Paiva A. Anxiolytic-like effect of Sonchus oleraceus L. in mice. J Ethnopharmacol. 2009;124;325-327. crossref(new window)

Carrasco MC, Vallejo JR, Pardo-de-Santayana M, Peral D, Martin MA, Altimiras J, Interactions of Valeriana officinalis L. and Passiflora incarnata L. in a patient treated with lorazepam. Phytother Res. 2009;23:1795-1796. crossref(new window)

Chao JY, Baik KU, Jung JH, Park MH. In vitro antiinflammatory effects of cynaropicrin, a sesquiterpene lactone, from Sassurea lappa. Eur J Pharmacol. 2000;398:399-407. crossref(new window)

Ching FP, Omogbai EK, Otokiti IO, Aqueous stern bark extract of Stereospermum kunthianum (Cham, Sandrine Petit) protects against generalized seizures in pentylenetetrazole and electro-convulsive models in rodents. Afr J Tradit Complement Altern Med. 2009;6:544-548.

Chisholm D. Cost-effectiveness of first-line antiepileptic drug treatments in the developing world: a population-level analysis. Epilepsia. 2005;46:751-759. crossref(new window)

Chitime HR, Chandra M, Kaushik S. Studies on anti-diarrhoeal activity of calotropis gigantea in experimental animals. J Pharm Pharm Sci. 2004;7:70-75.

Chopra RN, Nayar SL, Chopra IC. Glossary of Indian Medicinal Plants, 1st ed. (New Delhi, India:National Institute of Science Communication), pp. 85-126, 1996.

Cockerell OC, Johnson AL, Sander JW, Hart YM, Shorvon SD. Remission of epilepsy: results from the National general Practice study of epilepsy. Lancet. 1995;346:140-144. crossref(new window)

Council of Scientific & Industrial Research. The Wealth of India - A Dictionary of Indian Raw materials and Industrial products, Vol. 10. (New Delhi, India:CSIR), pp. 581-585, 1995.

Curio M, Jacone H, Perrut J, Pinto AC, Filho VF, Silva RC, Acute effect of Copaifera reticulata Ducke copaiba oil in rats tested in the elevated plus-maze: an ethological analysis. J Pharm Pharmacol. 2009;61:1105-1110. crossref(new window)

Debnath S, Kannadasan M, Ghosh S, Ghosh NS, Chakraborty R, Sen S. Antiepileptic activity of the hydroalcoholic extract of Erythrina fusca LOllI. bark against the animal models of MES, PTX and PTZ induced epileptic seizure models. Int J Chem Res. 2010;1:6-10.

Devinsky O. Cognitive and behavioral effects of antiepileptic drugs. Epilepsia. 1995;36:S46-S65. crossref(new window)

Dwivedi C. Antiepileptic Drugs. Am J Pharm Educ. 2001;65:197-202.

Fisher RS, van Emde Boas W, Blume W, Elger C, Genton P, Lee P, Engel J Jr. Epileptic seizures and epilepsy: Definitions proposed by the international league against epilepsy (ilae) and the international bureau for epilepsy (ibe). Epilepsia. 2005;46:470-472. crossref(new window)

French J, Smith M, Faught E, Brown L. Practice advisory: The use of felbamate in the treatment of patients with intractable epilepsy: Report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology. 1999;52:1540-1545. crossref(new window)

French JA, Kanner AM, Bautista J, Abou-Khalil B, Browne T, Harden CL, Theodore WH, Bazil C, Stern J, Schachter SC, Bergen D, Hirtz D, Montouris GD, Nespeca M, Gidal B, Marks WJ Jr, Turk WR, Fischer JH, Bourgeois B, Wilner A, Faught RE Jr, Sachdeo RC, Beydoun A, Glauser, TA. Efficacy and tolerability of the new antiepileptic drugs i: Treatment of new onset epilepsy: Report of the therapeutics and technology assessment subcommittee and quality standards subcommittee of the american academy of neurology and the american epilepsy society. Epilepsia. 2004;5:401-409.

Fulzele SV, Bhurchandi PM, Kanoje VM, Joshi SB, DorIe AK. Immunostimulant activity of Ashtamangal ghrita in rats. Indian J Pharmacol. 2002;34:194-197.

Gerlach AC, Krajewski JL. Antiepileptic Drug Discovery and Development: What Have We Learned and Where Are We Going? Pharmaceuticals. 2010;3:2884-2899. crossref(new window)

Gilani AH, Aziz N, Khan MA, Shaheen F, Jabeen Q, Siddiqui BS, Herzig JW. Ethnopharmacological evaluation of the anticonvulsant, sedative and antispasmodic activities of Lavandula stoechas L. J Ethnopharmacol. 2000;71:161-167. crossref(new window)

Giraldo SE, Rincon J, Puebla P, Marder M, Wasowski C, Vergel N, Guerrero MF, Isovaleramide, an anticonvulsant molecule isolated from Valeriana pavonii. Biomedica. 2010;30:245-250. crossref(new window)

Gomes PB, Noronha EC, de Melo CT, Bezerra JN, Neto MA, Lino CS, Vasconcelos SM, Viana GS, de Sousa FC, Central effects of isolated fractions from the root of Petiveria alliacea L. (tipi) in mice. J Ethnopharmacol. 2008;120:209-214. crossref(new window)

Gonzalez-Trujano ME, Lopez-Meraz L, Reyes-Ramirez A, Aguillon M, Martinez A, Effect of repeated administration of Annona diversifolia Saff.(ilama) extracts and palmitone on rat amygdala kindling. Epilepsy Behav. 2009;16:590-595. crossref(new window)

Goyal M, Nagori BP, Sasmal D, Sedative and anticonvulsant effects of an alcoholic extract of Capparis deciduas. J Nat Med. 2009;63:375-379. crossref(new window)

Grundmann O, Nakajima J, Kamata K, Seo S, Butterweck V, Kaempferol from the leaves of Apocynum veneturn possesses anxiolytic activities in the elevated plus maze test in mice. Phytomedicine.2009;16:295-302. crossref(new window)

Gupta M, Muzumdar UK, Chakrabrati S. CNS activities of methanolic extract of Moringa oleifera root in mice. Fitoterapia. 1999;70:244-250. crossref(new window)

Gupta YK, Sharma M, Chaudhary G. Antiepileptic activity of Panax ginseng against pentylenetetrazole induced kindling in rats. Indian J Physiol Pharmacol. 2001;45:502-506.

Hauser WA, Annegers JF, Kurland LT. Prevalence of epilepsy in Rochester, Minnesota: 1940-1980. Epilepsia. 1991;32:429-445. crossref(new window)

Hauser WA, Annegers JF. Epidemiology of Epilepsy. In Laidlam J. Richen A ad Chadwick D. ed. Textbook of epilepsy. Churchill Livingstone: Edinburgh. 1993;23-45.

Holmes GL. Critical issues in the treatment of epilepsy. Am J Hosp Pharm 1993;50:S5-S16.

Hosseinzadeh H, Karimi GR, Rakhshanizadeh M. Anticonvulsant effect of Hypericum perforatum: role of nitric oxide. J Ethnopharmacol. 2005;98:207-208. crossref(new window)

Hosseinzadeh H, Parvardeh S. Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice. Phytomedicine. 2004;11:56-64. crossref(new window)

Abe K, Saito H. Effects of saffron extract and its constituent crocin on learning behaviour and long-term potentiation. Phytother Res. 2000;14:149-152. crossref(new window)

Huen MS, Leung JW, Ng W, Lui WS, Chan MN, Wong JT, Xue H. 5,7-Dihydroxy-6-methoxyflavone, a benzodiazepine site ligand isolated from Scutellaria baicalensis Georgi, with selective antagonistic properties. Biochem Pharmacol. 2003;66:125-132. crossref(new window)

Huguenard JR. Neuronal circuitry of thalamocortical epilepsy and mechanisms of antiabsence drug action. Adv Neurol. 1999;79:991-1000.

Janahmadi M, Farajnia S, Vatanparast J, Abbasipour H, Kamalinejad M. The fruit essential oil of Pimpinella anisum L.(Umblliferae) induces neuronal hyperexcitability in snail partly through attenuation of after-hyperpolarization. J Ethnopharmacol. 2008;120:360-365. crossref(new window)

Jawaid T, Argal S, Singh S. Botanicals and herbs: A traditional approach in treatment of epilepsy. J Pharm Res. 2011;4: 1138-1140.

Kabir M, Iliyasu Z, Abubakar IS, Kabir ZS, Farinyaro AU. Knowledge. Attitude and Beliefs about epilepsy among adults in a northern Nigerian urban community. Annals of Afr Med. 2005;4:107-112.

Kasture VS, Kasture SB, Chopde CT. Anticonvulsive activity of Butea monosperma flowers in laboratory animals. Pharmacol Biochem Behav. 2002;72:965-972. crossref(new window)

Katiyar C, Kumar A, Bhattacharya SK, Singh RS. Ayurvedic processed seeds of Nuxvomica: neuropharmacological and chemical evaluation. Fitoterapia. 2010;81:190-195. crossref(new window)

Kavimani S, Iiango R, Madheswaran M, Jayakar B, Gupta M, Majumdar UK. Antitumor activity of plumbagin gainst dalton's ascitic lymphoma.2 Indian J Pharm Sci. 1996;58:194-196.

Kirtikar KR, Basu BD. Indian Medicinal Plants. (Allahabad, India: Lalit Mohan Basu), pp. 1546-1549, 2003.

Kirtikar KR, Basu BD. Indian Medicinal Plants. Vol. 3. (Dehradun, India: International Book Distributors), 1998.

Kritikar KR, Basu BD. Indian Med Plants. Vol. 2. (Dehradun, India: Shiva Publishers), 1993.

Kulkarni S, Desai S. Immunostimulant activity of inulin isolated from Saussurea lappa roots. Indian J Pharm Sci. 2001;63:292-294.

Maiha BB, Magaji MG, Yaro AH, Hamza AH, Ahmed ST and Magaji RA. Anticonvulsant Studies on Cochlospermum Tinctorium and Paullinia Pinnata Extracts in Laboratory Animals. Nig J Pharm Sci. 2009;8:102-108.

Mattson RH. Efficacy and adverse effects of established and new antiepileptic drugs. Epilepsia. 1995;36:S13-S26. crossref(new window)

Miwa H, Iijima M, Tanaka S, Mizuno Y. Generalized convulsions after consuming a large amount of Gingko nuts. Epilepsia.2001;42:280-281.

Mohanraj R, Brodie MJ. Measuring the efficacy of antiepileptic drugs. Seizure. 2003;12:413-443. crossref(new window)

Muceniece R, Saleniece K, Krigere L, Rumaks J, Dzirkale Z, Mezhapuke R, Kviesis J, Mekss P, Klusa V, Schioth HB, Dambrova M. Potato (Solanum tuberosum) juice exerts an anticonvulsant effect in mice through binding to GABA receptors. Planta Med. 2008;74:491-496. crossref(new window)

Mishra N, Oraon A, Dev A, Jayaprakash V, Basu A, Pattnaik AK, Tripapthi SN, Akhtar M, Ahmad S, Swaroop S, Basu M. Anticonvulsant activity of Benkara malabarica (Linn.) root extract: In vitro and in vivo investigation. J Ethnopharmacol. 2010;128;533-536. crossref(new window)

Nqo Bum E, Taiwe GS, Moto FC, Ngoupaye GT, Nkantchoua GC, Pelanken MM, Rakotonirina SV, Rakotonirina A. Anticonvulsant, anxiolytic, and sedative properties of the roots of Nauclea latifolia Smith in mice. Epilepsy Behav. 2009;15:434-440. crossref(new window)

Okokon JE, Nwafor PA, Antiulcer and anticonvulsant activity of Croton zambesicus. Pak J Pharm Sci. 2009;22;384-390.

Oliveira FA, de Almeida RN, Sousa MF, Barbosa-Filho JM, Diniz SA, Medeiros IA. Anticonvulsant properties of N-salicyloyltryptamine in mice. Pharmacol Biochem Behav. 2001;68:199-202. crossref(new window)

Pal D, Dutta S, Sarkar A. Evaluation of CNS activities of ethanol extract of roots and rhizomes of Cyperus rotundus in mice. Acta Pol Pharm. 2009;66:535-541.

Pedersen ME, Vestergaard HT, Stafford GI, van Staden J, Jager AK. The effect of extracts of Searsia species on epileptiform activity in slices of the mouse cerebral cortex. J Ethnopharmacol. 2008;119:538-541. crossref(new window)

Raza M, Shaheen F, Choudhary MI, Sambati S, Rafig A, Suria A, Atta-ur-Rahman, DeLorenzo, R J. Anticonvulsant activities of ethanolic extract and aqueous fraction isolated from Delphinium denudatum. J. Ethnopharmacol. 2001;78:73-78. crossref(new window)

Reddy J, Gnanasekaran D, Vijay D, Ranganathan TV. In vitro studies on anti asthmatic, analgesic and anti convulsant activities of the medicinal plant Bryonia laciniosa. Linn. Inter J Drug Disc. 2010;2:1-10 crossref(new window)

Reza HM , Mohammad H, Golnaz E, Gholamreza S, Effect of methanolic extract of Hyoscymus niger L. on the seizure induced by picritoxin in mice. Pak J Pharm Sci. 2009;22:308-312.

Rho JM, Sankar R. The pharmacologic basis of antiepileptic drug action. Epilepsia. 1999;40:1471-1483. crossref(new window)

Ribeiro RA, Leite JR. Nantenine alkaloid presents anticonvulsant effect on two classical animal models. Phytomedicine. 2003;10:563-568. crossref(new window)

Rogawski MA, Loscher W. The neurobiology of antiepileptic drugs. Nat Rev Neurosci. 2004;5:553-564. crossref(new window)

Saini P, Kannapan N, Diwan A, Kumar P, Antil V, Sharma S, Singh S. Anticonvulsant activity of flower part of N. oderum. Inter J Pharma & Bio Sci. 2010;1:1-4.

Sayyah M, Mandgary A, Kamalinejad M. Evaluation of the anticonvulsant activity of the seed acetone extract of Ferula gummosa Boiss. against seizures induced by pentylenetetrazole and electroconvulsive shock in mice. J Ethnopharmacol. 2002;82:105-109. crossref(new window)

Sayyah M, Valizadeh J, Kamalinejad M. Anticonvulsant activity of the leaf essential oil of Laurus nobilis against pentylenetetrazole- and maximal electroshock-induced seizures. Phytomedicine. 2002;9:212-216. crossref(new window)

Silva FO, Silva MG, Feng D, de Freitas RM. Evaluation of central nervous system effects of iso-6-cassine isolated from Senna spectabilis var. excelsa (Schrad) in mice, Fitoterapia. 2011;82:255-259. crossref(new window)

Silva MR, Ximenes RM, da Costa JG, Leal LK, de Lopes AA, Viana GS, Comparative anticonvulsant activities of the essential oils (EOs) from Cymbopogon winterianus Jowitt and Cymbopogon citratus (DC) Stapf. in mice. Nau Schr Arch Pharm 2010;381:415-426. crossref(new window)

Singh D, Goel RK. Anticonvulsant effect of Ficus religiosa: role of serotonergic pathways. J Ethnopharmacol. 2009;123:330-334. crossref(new window)

Smith MC, Bleck TP. Convulsive Disorders: toxicity of anticonvulsants. Clin Neuropharmacol. 1991;14:97-115. crossref(new window)

Sridharan, R. Epidemiology of epilepsy. Current Science. 2002;82:664-670.

Sumathy T, Subramanian S, Govindaswamy S, Balakrishna K, Veluchamy G. Protective role of Bacopa monniera on morphine induced hepatotoxicity in rats. Phytother Res. 2001;15:643-645. crossref(new window)

Umukoro S, Aladeokin AC. Evaluation of the anti-stress and anticonvulsant activities of leaf extract of Alchornea cordifolia in mice. J Ethnopharmacol. 2010;127:768-770. crossref(new window)

Vasudevan M, Parle M. Antianmesic potential of Murraya koenigii leaves. Phytother Res. 2009;23:308-316. crossref(new window)

Visweswari G, Prasad KS, Chetan PS, Lokanatha V, Rajendra W. Evaluation of the anticonvulsant effect of Centella asiatica (gotu kola) in pentylenetetrazol-induced seizures with respect to cholinergic neurotransmission. Epilepsy Behav. 2010;17:332-335. crossref(new window)

Vyawahare NS, Bodhankar SL, Anticonvulsant Activity of Argyreia speciosa in Mice. Indian J Pharm Sci. 2009;71:131-134. crossref(new window)

Wagh RV, Antre RV, Oswal RJ, Nimje HM. Anticonvulsant Activity: An Overview. JPSBR 2011;1:142-147.

Wahab A, UI Haq R, Ahmed A, Khan RA, Raza M. Anticonvulsant activities of nutmeg oil of Myristica fragrans. Phytother Res. 2009;23:153-158. crossref(new window)

Wang HH, Liao JF, Chen CF. Anticonvulsant effect of water extract of Scutellariae radix in mice. J Ethnopharmacol. 2000;73:185-190. crossref(new window)