JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Evaluation of anti-inflammatory effect of traditional medicinal plants, Gynura segetum
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
  • Journal title : TANG [HUMANITAS MEDICINE]
  • Volume 4, Issue 1,  2014, pp.4.1-4.4
  • Publisher : Association of Humanitas Medicine
  • DOI : 10.5667/tang.2013.0035
 Title & Authors
Evaluation of anti-inflammatory effect of traditional medicinal plants, Gynura segetum
Seow, Lay-Jing; Beh, Hooi-Kheng; Sadikun, Amirin; Asmawi, Mohd Zaini;
  PDF(new window)
 Abstract
Gynura segetum, family Asteraceae is a cultivated species and can be found growing in the tropical regions of Indonesia and Malaysia. The plant is known for its use for the treatment of cancer, inflammation, diabetes, hypertension and skin afflictions. In the current study, anti-inflammatory effect of Gynura segetum leaf has been investigated. The present study investigated the in vivo anti-inflammatory effect of Gynura segetum leaf by using hen's egg test-chorioallantoic membrane (HET-CAM) assay. Different solvent extract of Gynura segetum leaf were tested, the most active methanol extract was further fractionated and tested. Among the extracts tested, the methanol extract showed a significant good anti-inflammatory effect (76.8% inhibition at 50 ) on the HET-CAM assay as compared with the anti-inflammatory drug indomethacin (82.1% inhibition). However, the fractionated sample exhibited a significantly lower activity in comparison to crude methanol extract. The results demonstrated that Gynura segetum leaf displayed remarkable anti-inflammatory effects, which support the folkloric uses of this plant for treatment of inflammation.
 Keywords
Gynura segetum;Asteraceae;HET-CAM;anti-inflammatory;
 Language
English
 Cited by
1.
Anti-inflammatory and antioxidant activities of the methanol extract of Gynura segetum leaf, International Immunopharmacology, 2014, 23, 1, 186  crossref(new windwow)
 References
1.
Abdillahi HS, Finnie JF, Van Staden J. Anti-inflammatory, antioxidant, anti-tyrosinase and phenolic contents of four Podocarpus species used in traditional medicine in South Africa. J Ethnopharmacol. 2011;136:496-503. crossref(new window)

2.
Ahn EK, Jeon HJ, Lim EJ, Jung HJ, Park EH. Anti-inflammatory and anti-angiogenic activities of Gastrodia elata Blume. J Ethnopharmacol. 2007;110:476-482. crossref(new window)

3.
Burgermeister J, Paper DH, Vogl H, Linhardt RJ, Franza G. LaPSvS1, a ($1{\rightarrow}3)-{\beta}$- galactan sulfate and its effect on angiogenesis in vivo and in vitro. Carbohyd Res. 2002;337:1459-1466. crossref(new window)

4.
Cho SY, Lee YN, Park HJ. Optimization of ethanol extraction and further purification of isoflavones from soybean sprout cotyledon. Food Chem. 2009;117:312-317. crossref(new window)

5.
Doss A, Phil M. Preliminary phytochemical screening of some Indian medicinal plants. Anc Sci Life. 2009;29:12-16.

6.
Griffioen AW, Molema G. Angiogenesis: potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation. Pharmacol Rev. 2000;52:237-268.

7.
Jackson JR, Seed MP, Kircher CH, Willoughby DA, Winkler JD. The codependemce of angiogenesis and chronic inflammation. FASEB J. 1997;11:457-465.

8.
Jung HJ, Song YS, Lim CJ, Park EH. Anti-inflammatory, anti-angiogenic and anti-nociceptive activities of an ethanol extract of Salvia plebeia R. Brown. J Ethnopharmacol. 2009;126:355-360. crossref(new window)

9.
Kim SH, Song YS, Kim SK, Kim BC, Lim CJ, Park EH. Anti-inflammatory and related pharmacological activities of the n-BuOH subfraction of mushroom Phellinus linteus. J Ethnopharmacol. 2004;93:141-146. crossref(new window)

10.
Krenn L, Paper DH. Inhibition of angiogenesis and inflammation by an extract of red clover (Trifolim pratense L.). Phytomedicine. 2009;16:1083-1088. crossref(new window)

11.
Masresha B, Makonnen E, Debella A. In vivo anti-inflammatory activities of Ocimum suave in mice. J Ethnopharmacol. 2012;142: 201-205. crossref(new window)

12.
Mathur R, Gupta SK, Singh N, Mathur S, Kochupillai V, Velpandian T. Evaluation of the effect of Withania somnifera root extracts on cell cycle and angiogenesis. J Ethnopharmacol. 2006;105:336-341. crossref(new window)

13.
Min JK, Han KY, Kim EC, Kim YM, Lee SW, Kim OH. Capsaicin inhibits in vitro and in vivo angiogenesis. Cancer Res. 2004;64:644-651. crossref(new window)

14.
Peng CC, Hsieh CL, Lin LY, Chyau CC, Cheng YT, Chen KC, Peng RY. Anisotropic diffusion deviates chicken embryo chorioallantoic membrane assay (CAM) to reflect inherent therapeutic behaviors. Colloids Surf B Biointerfaces. 2009;70:29-34. crossref(new window)

15.
Rathore SK, Bhatt S, Dhyani S, Jain A. Preliminary phytochemical screening of medicinal plant Ziziphus mauritiana Lam. Fruits. Int J Curr Pharm Res. 2012;4:160-162.

16.
Seow LJ, Beh HK, Abdul Majid AMS, Murugaiyah V, Ismail N, Asmawi MZ. Anti-angiogenic activity of Gynura segetum leaf extracts and its fractions. J Ethnopharmacol. 2011;134:221-227. crossref(new window)

17.
Seow LJ, Beh HK, Sadikun A, Asmawi MZ. Preliminary Phytochemical and Physicochemical Characterization of Gynura segetum (Lour.) Merr (Compositae) Leaf. Trop J Pharm Res. 2013;12:777-782.

18.
Torey A, Sasidharan S, Yeng C, Yoga Latha LY. Standardization of Cassia spectabilis with respect to authenticity, assay and chemical constituent analysis. Molecules. 2010;15:3411-3420. crossref(new window)

19.
Walsh DA, Pearson CI. Angiogenesis in the pathogenesis of inflammatory joint and lung diseases. Arthritis Res. 2001;3:147-153. crossref(new window)

20.
Zhu BR, Pu SB, Wang KDG, Xu DR, Zhou HH. Chemical constituents of the aerial part of Gynura segetum. Biochem Syst Ecol. 2013;46:4-6. crossref(new window)