JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Potential mechanism of anti-diabetic activity of Picrorhiza kurroa
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
  • Journal title : TANG [HUMANITAS MEDICINE]
  • Volume 4, Issue 4,  2014, pp.27.1-27.5
  • Publisher : Association of Humanitas Medicine
  • DOI : 10.5667/tang.2014.0013
 Title & Authors
Potential mechanism of anti-diabetic activity of Picrorhiza kurroa
Husain, Gulam Mohammed; Rai, Richa; Rai, Geeta; Singh, Harikesh Bahadur; Thakur, Ajit Kumar; Kumar, Vikas;
  PDF(new window)
 Abstract
Picrorhiza kurroa Royle ex Benth. (Scrophulariaceae) is a traditional Ayurvedic herb known as Kutki. It is used as a remedy for diabetes by tribes of North Eastern Himalayan region of India. Present study was conducted to explore the mechanism of antidiabetic activity of standardized aqueous extract of Picrorhiza kurroa (PkE). PkE (100 and 200 mg/kg/day) was orally administered to streptozotocin induced diabetic rats, for 14 consecutive days. Plasma insulin levels were measured and pancreas of rat was subjected to histopathological investigations. Glucose transporter type 4 (GLUT-4) protein content in the total membrane fractions of soleus muscle was estimated by Western blot analysis. Plasma insulin level was significantly increased along with concomitant increase in GLUT-4 content of total membrane fractions of soleus muscle of diabetic rats treated with extract. There was evidence of regeneration of -cells of pancreatic islets of PkE treated group in histopathological examinations. PkE increased the insulin-mediated translocation of GLUT-4 from cytosol to plasma membrane or increased GLUT-4 expression, which in turn facilitated glucose uptake by skeletal muscles in diabetic rats.
 Keywords
Picrorhiza kurroa;type 2 diabetes;GLUT-4;pancreas;histopathology;
 Language
English
 Cited by
1.
Picrorhiza kurroa Enhances β-Cell Mass Proliferation and Insulin Secretion in Streptozotocin Evoked β-Cell Damage in Rats, Frontiers in Pharmacology, 2017, 8  crossref(new windwow)
 References
1.
Ansari RA, Tripathi SC, Patnaik GK, Dhawan BN. Antihepatotoxic properties of picroliv: an active fraction from rhizomes of Picrorhiza kurrooa. J Ethnopharmacol. 1991;34:61-68. crossref(new window)

2.
Basu K, Dasgupta B, Ghosal S. Chemistry of kutkin, isolated from Picrorhiza kurroa Royle ex Benth. Experientia. 1970;26:818-819. crossref(new window)

3.
Berger J, Biswas C, Vicario PP, Strout HV, Saperstein R, Pilch PF. Decreased expression of the insulin-responsive glucose transporter in diabetes and fasting. Nature. 1989;340:70-72. crossref(new window)

4.
Chhetri DR, Parajuli P, Subba GC. Antidiabetic plants used by Sikkim and Darjeeling Himalayan tribes, India. J Ethnopharmacol. 2005;99:199-202. crossref(new window)

5.
Dwivedi Y, Rastogi R, Garg NK, Dhawan BN. Picroliv and its components kutkoside and picroside I protect liver against galactosamine-induced damage in rats. Pharmacol Toxicol. 1992;71:383-387. crossref(new window)

6.
Friederich M, Hansell P, Palm F. Diabetes, oxidative stress, nitric oxide and mitochondria function. Curr Diabetes Rev. 2009;5:120-144. crossref(new window)

7.
Hardin DS, Dominguez JH, Garvey WT. Muscle group-specific regulation of GLUT-4 glucose transporters in control, diabetic, and insulin-treated diabetic rats. Metabolism. 1993;42:1310-1315. crossref(new window)

8.
Husain GM, Singh PN, Kumar V. Antidiabetic activity of standardized extract of Picrorhiza kurroa in rat model of NIDDM. Drug Discov Ther. 2009;3:88-92.

9.
International Diabetes Federation. IDF DIABETES ATLAS. 6th ed. (Brussels, Belgium: International Diabetes Federation), 2013. http://www.idf.org/sites/default/files/DA6_Regional_factsheets_0.pdf

10.
Kellerer M, Lammers R, Haring, HU. Insulin signal transduction: possible mechanism for insulin resistance. Exp Clin Endocrinol Diabetes. 1999;107:97-106. crossref(new window)

11.
Kern M, Loomis TA, Tapscott EB, Dohm GL. Increased muscle glucose uptake in response to chronic glyburide treatment is not related to changes in glucose transporter (GLUT4) protein. Int J Biochem. 1993;25:1257-1261. crossref(new window)

12.
Kosegawa I, Chen S, Awata T, Negishi K, Katayama S. Troglitazone and metformin, but not glibenclamide, decrease blood pressure in Otsuka Long Evans Tokushima Fatty rats. Clin Exp Hypertens. 1999;21:199-211. crossref(new window)

13.
Kumar V, Sood H, Sharma M, Chauhan RS. A proposed biosynthetic pathway of picrosides linked through the detection of biochemical intermediates in the endangered medicinal herb Picrorhiza kurroa. Phytochem Anal. 2013;24:598-602. crossref(new window)

14.
Luper S. A review of plants used in the treatment of liver disease: part 1. Altern Med Rev. 1998;3:410-421.

15.
Luzi L, Pozza G. Glibenclamide: an old drug with a novel mechanism of action? Acta Diabetol. 1997;34:239-244. crossref(new window)

16.
Masiello P, Broca C, Gross R, Roye M, Manteghetti M, Hillaire-Buys D, Novelli M, Ribes G. Experimental NIDDM:development of a new model in adult rats administered streptozotocin and nicotinamide. Diabetes. 1998;47:224-229. crossref(new window)

17.
Nizamutdinova IT, Jin YC, Chung JI, Shin SC, Lee SJ, Seo HG, Lee JH, Chang KC, Kim HJ. The anti-diabetic effect of anthocyanins in streptozotocin-induced diabetic rats through glucose transporter 4 regulation and prevention of insulin resistance and pancreatic apoptosis. Mol Nutr Food Res. 2009;53:1419-1429. crossref(new window)

18.
Ong KW, Hsu A, Song L, Huang D, Tan BK. Polyphenols-rich Vernonia amygdalina shows anti-diabetic effects in streptozotocin-induced diabetic rats. J Ethnopharmacol. 2011;133:598-607. crossref(new window)

19.
Proks P, Reimann F, Green N, Gribble F, Ashcroft F. Sulfonylurea stimulation of insulin secretion. Diabetes. 2002;51:S368-S376. crossref(new window)

20.
Rai A, Eapen C, Prasanth VG. Interaction of herbs and glibenclamide: a review. ISRN Pharmacol. 2012;2012:659478.

21.
Ross MH, Reith EJ, Romrell LJ. Histology: A Text and Atlas. (Baltimore, USA: Williams and Wilkins), 1989.

22.
Stuppner H, Wagner H. New cucurbitacin glycosides from Picrorhiza kurroa. Planta Med. 1989;55:559-563. crossref(new window)

23.
Sud A, Chauhan RS, Tandon C. Identification of imperative enzymes by differential protein expression in Picrorhiza kurroa under metabolite accumulating and non-accumulating conditions. Protein Pept Lett. 2013;20:826-835. crossref(new window)

24.
Tahara A, Matsuyama-Yokono A, Nakano R, Someya Y, Shibasaki M. Effects of antidiabetic drugs on glucose tolerance in streptozotocin-nicotinamide-induced mildly diabetic and streptozotocin-induced severely diabetic mice. Horm Metab Res. 2008;40:880-886. crossref(new window)

25.
Wu KK, Huan Y. Streptozotocin-induced diabetic models in mice and rats. Curr Protoc Pharmacol. 2008;5:Unit 5.47.

26.
Zhou M, Sevilla L, Vallega G, Chen P, Palacin M, Zorzano A, Pilch PF, Kandror KV. Insulin-dependent protein trafficking in skeletal muscle cells. Am J Physiol. 1998;275:E187-E196.

27.
Ziel FH, Venkatesan N, Davidson MB. Glucose transport is rate limiting for skeletal muscle glucose metabolism in normal and STZ-induced diabetic rats. Diabetes. 1988;37:885-890. crossref(new window)