Advanced SearchSearch Tips
Potential of some traditionally used edible plants for prevention and cure of diabesity associated comorbidities
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
  • Journal title : TANG [HUMANITAS MEDICINE]
  • Volume 5, Issue 2,  2015, pp.8.1-8.22
  • Publisher : Association of Humanitas Medicine
  • DOI : 10.5667/tang.2014.0026
 Title & Authors
Potential of some traditionally used edible plants for prevention and cure of diabesity associated comorbidities
Kumar, Vikas; Thakur, Ajit Kumar; Verma, Suruchi; Yadav, Vaishali; Chatterjee, Shyam Sunder;
  PDF(new window)
Medicinal uses of edible and other plants for prevention and cure of obesity and overweight associated metabolic and mental health problems have since long been known to scholars and practitioners of Ayurvedic and other traditionally known system of medicine. Modernized versions of numerous edible plant derived formulations mentioned in ancient Ayurvedic texts are at present some of the most popular, or best selling, herbal remedies in India and numerous other countries suffering from double burden of diseases caused by malnutrition and obesity. Preclinical and clinical information now available on edible plants and their bioactive constituents justify traditionally known medicinal uses of products derived from them for prevention and cure of obesity associated type-2 diabetes, psychopathologies and other health problems. Such information now available on a few edible Ayurvedic plants and their formulations and suggesting that their stress response regulating effects are involved in their broad spectrums of bioactivity profiles are summarized in this communication. Implications of recent physiological and pharmacological observations made with numerous phytochemicals isolated from edible plants for better understanding of traditionally known medicinal uses of herbal remedies are also pointed out.
Ayurveda;diabesity;neurological disorders;Brassica juncea;Emblica officinalis;Piper longum;Curcuma;
 Cited by
Stress resistance promoting potentials of turmeric oil and curcuminoids in mice,;;;;;

Oriental Pharmacy and Experimental Medicine, 2016. vol.16. 3, pp.185-194 crossref(new window)
Abedon ST. Phage therapy: Eco-physiological pharmacology. Scientifica (Cairo). 2014;2014:581639.

Abu-Taweel GM, Ajarem JS, Ahmad M. Protective effect of curcumin on anxiety, learning behavior, neuromuscular activities, brain neurotransmitters and oxidative stress enzymes in cadmium intoxicated mice. J Behav Brain Sci. 2013;3:74-84. crossref(new window)

Adam TC, Epel ES. Stress, eating and the reward system. Physiol Behav. 2007;91:449-458. crossref(new window)

Afridi HI, Kazi TG, Kazi N, Jamali MK, Arain MB, Jalbani N, Baig JA, Sarfraz RA. Evaluation of status of toxic metals in biological samples of diabetes mellitus patients. Diabetes Res Clin Pract. 2008;80:280-288. crossref(new window)

Agarwal NB, Jain S, Agarwal NK, Mediratta PK, Sharma KK. Modulation of pentylenetetrazole-induced kindling and oxidative stress by curcumin in mice. Phytomedicine. 2011;18:756-759. crossref(new window)

Aggarwal B, Sundaram C, Malani N, Ichikawa H. Curcumin: The indian solid gold. In The molecular targets and therapeutic uses of curcumin in health and disease. Adv Exp Med Biol. 2007;595:1-75. crossref(new window)

Aggarwal BB, Yuan W, Li S, Gupta SC. Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric. Mol Nutr Food Res. 2013;57:1529-1542. crossref(new window)

Agrawal S, Millett CJ, Dhillon PK, Subramanian SV, EbrahimS. Type of vegetarian diet, obesity and diabetes in adult indian population. Nutr J. 2014;13:89. crossref(new window)

Ahmed B, Tripathi K, Pandey ND, Khan M. Piperone-3 and piperone-4: Two new ketones isolated from Piper longum L. Dried fruits. Intl J Pharm Sci Rev Res. 2014;26:318-321.

Ahmed SH, Guillem K, Vandaele Y. Sugar addiction: Pushing the drug-sugar analogy to the limit. Curr Opin Clin Nutr Metab Care. 2013;16:434-439. crossref(new window)

Ahmed T, Gilani AH. Therapeutic potential of turmeric in alzheimer's disease: Curcumin or curcuminoids?. Phytother Res. 2014;28:517-525. crossref(new window)

Akinloye O, Ogunleye K, Oguntibeju OO. Cadmium, lead, arsenic and selenium levels in patients with type 2 diabetes mellitus. African J Biotechnol. 2013;9:5189-5195.

Alappat L, Awad AB. Curcumin and obesity: Evidence and mechanisms. Nutr Rev. 2010;68:729-738. crossref(new window)

Ali RE, Rattan SI. Curcumin's biphasic hormetic response on proteasome activity and heat-shock protein synthesis in human keratinocytes. Ann N Y Acad Sci. 2006;1067:394-399. crossref(new window)

Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. Bioavailability of curcumin: Problems and promises. Mol Pharm. 2007;4:807-818. crossref(new window)

Anannarukan N, Niwattisaiwong N, Warisnoicharoen W, Winitthana T, Pramyothin P, Chaichantipyuth C, Lawanprasert S. Inhibition of human cytochrome p450 in vitro by phyllanthus amarus and Phyllanthus emblica aqueous extracts. Thai J Pharm Sci. 2012;36:135-143.

Anonymous. Position of the american dietetic association and dietitians of canada: Vegetarian diets. J Am Diet Assoc. 2003;103:748-765. crossref(new window)

Aroniadis OC, Brandt LJ. Fecal microbiota transplantation: Past, present and future. Curr Opin Gastroenterol. 2013;29:79-84. crossref(new window)

Asolkar LV, Kakkar KK, Chakre OJ. Glossary of indian medicinal plants with active principles, second supplement. (New Delhi, India; Publication and Information Directorate, CSIR), 1992.

Baboota RK, Bishnoi M, Ambalam P, Kondepudi KK, Sarma SM, Boparai RK, Podili K. Functional food ingredients for the management of obesity and associated co-morbidities - a review. J Funct Foods. 2013;5:997-1012. crossref(new window)

Babu PS, Srinivasan K. Hypolipidemic action of curcumin, the active principle of turmeric (Curcuma longa) in streptozotocin induced diabetic rats. Mol Cell Biochem. 1997;166:169-175. crossref(new window)

Balaji S, Chempakam B. Toxicity prediction of compounds from turmeric (Curcuma longa l). Food Chem Toxicol. 2010;48:2951-2959. crossref(new window)

Banks WA, Owen JB, Erickson MA. Insulin in the brain: There and back again. Pharmacol Ther. 2012;136:82-93. crossref(new window)

Bao L, Bai S, Borijihan G. Hypolipidemic effects of a new piperine derivative gb-n from Piper longum in high-fat diet-fed rats. Pharm Biol. 2012;50:962-967. crossref(new window)

Bao N, Ochir S, Sun Z, Borjihan G, Yamagishi T. Occurrence of piperidine alkaloids in piper species collected in different areas. J Nat Med. 2014;68:211-214. crossref(new window)

Barrajon-Catalan E, Herranz-Lopez M, Joven J, Segura-Carretero A, Alonso-Villaverde C, Menendez JA, Micol V. Molecular promiscuity of plant polyphenols in the management of age-related diseases: Far beyond their antioxidant properties. Adv Exp Med Biol. 2014;824:141-159. crossref(new window)

Baty V, Mougin B, Dekeuwer C, Carret G. Gut health in the era of the human gut microbiota: From metaphor to biovalue. Med Health Care Philos. 2014;17:579-597. crossref(new window)

Belapurkar P, Goyal P, Tiwari-Barua P. Immunomodulatory effects of triphala and its individual constituents: A review. Indian J Pharm Sci. 2014;76:467-475.

Bezerra DP, Pessoa C, de Moraes MO, Saker-Neto N, Silveira ER, Costa-Lotufo LV. Overview of the therapeutic potential of piplartine (piperlongumine). Eur J Pharm Sci. 2013;48:453-463. crossref(new window)

Bhanumathy M, Shivaprasad HN, Nargund LVG. Protective effect of Curcuma longa rhizomes against physical stressinduced perturbations in rats. J Nat Remedies. 2013;14:27-32.

Bharal N, Sahaya K, Jain S, Mediratta PK, Sharma KK. Curcumin has anticonvulsant activity on increasing current electroshock seizures in mice. Phytother Res. 2008;22:1660-1664. crossref(new window)

Bhatia N, Jaggi A, Singh N, Anand P, Dhawan R. Adaptogenic potential of curcumin in experimental chronic stress and chronic unpredictable stress-induced memory deficits and alterations in functional homeostasis. J Nat Med. 2011;65:532-543. crossref(new window)

Biradar YS, Jagatap S, Khandelwal KR, Singhania SS. Exploring of antimicrobial activity of triphala mashi-an ayurvedic formulation. Evid Based Complement Alternat Med. 2008;5:107-113. crossref(new window)

Birringer M. Hormetics: Dietary triggers of an adaptive stress response. Pharm Res. 2011;28:2680-2694. crossref(new window)

Bolca S, Van de Wiele T, Possemiers S. Gut metabotypes govern health effects of dietary polyphenols. Curr Opin Biotechnol. 2013;24:220-225. crossref(new window)

Bradford PG. Curcumin and obesity. Biofactors. 2013;39:78-87. crossref(new window)

BrahmaNaidu P, Nemani H, Meriga B, Mehar SK, Potana S, Ramgopalrao S. Mitigating efficacy of piperine in the physiological derangements of high fat diet induced obesity in sprague dawley rats. Chem Biol Interact. 2014;221:42-51. crossref(new window)

Brekhman II, Dardymov IV. New substances of plant origin which increase nonspecific resistance. Annu Rev Pharmacol. 1969;9:419-430. crossref(new window)

Brindley DN, Rolland Y. Possible connections between stress, diabetes, obesity, hypertension and altered lipoprotein metabolism that may result in atherosclerosis. Clin Sci (Lond). 1989;77:453-461. crossref(new window)

Brodniewicz T, Grynkiewicz G. Plant phenolics as drug leads - what is missing? Acta Pol Pharm. 2012;69:1203-1217.

Burcelin R, Serino M, Chabo C, Blasco-Baque V, Amar J. Gut microbiota and diabetes: From pathogenesis to therapeutic perspective. Acta Diabetol. 2011;48:257-273. crossref(new window)

Calabrese EJ. Hormesis is central to toxicology, pharmacology and risk assessment. Hum Exp Toxicol. 2010;29:249-261. crossref(new window)

Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ. Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity. Biochim Biophys Acta. 2012;1822:753-783. crossref(new window)

Calabrese V, Cornelius C, Trovato A, Cavallaro M, Mancuso C, Di Rienzo L, Condorelli D, De Lorenzo A, Calabrese EJ. The hormetic role of dietary antioxidants in free radical-related diseases. Curr Pharm Des. 2010;16:877-883. crossref(new window)

Carriba P, Comella JX. Amyloid beta, tnfalpha and faim-l; approaching new therapeutic strategies for ad. Front Neurol. 2014;5:276.

Cartea ME, Francisco M, Soengas P, Velasco P. Phenolic compounds in brassica vegetables. Molecules. 2010;16:251-280. crossref(new window)

Carvalho LA, Urbanova L, Hamer M, Hackett RA, Lazzarino AI, Steptoe A. Blunted glucocorticoid and mineralocorticoid sensitivity to stress in people with diabetes. Psychoneuroendocrinology. 2015;51:209-218. crossref(new window)

Chainani-Wu N. Safety and anti-inflammatory activity of curcumin: A component of tumeric (Curcuma longa). J Altern Complement Med. 2003;9:161-168. crossref(new window)

Chandra P, Bajpai V, Srivastva M, Kumar KBR, Kumar B. Metabolic profiling of piper species by direct analysis using real time mass spectrometry combined with principal component analysis. Anal Methods. 2014;6:4234-4239. crossref(new window)

Chandrasekaran C, Vijayalakshmi M, Prakash K, Bansal V, Meenakshi J, Amit A. Review article: Herbal approach for obesity management. Am J Plant Sci. 2012;3:1003-1014. crossref(new window)

Chang CL, Chen YC, Chen HM, Yang NS, Yang WC. Natural cures for type 1 diabetes: A review of phytochemicals, biological actions, and clinical potential. Curr Med Chem. 2013a;20:899-907.

Chang CL, Lin Y, Bartolome AP, Chen YC, Chiu SC, Yang WC. Herbal therapies for type 2 diabetes mellitus: Chemistry, biology, and potential application of selected plants and compounds. Evid Based Complement Alternat Med. 2013b;2013:378657.

Chatterjee SS, Kumar V. Holistic psychopharmacology and promiscuous plants and principles of ayurveda. Am J Plant Sci. 2012;3:1015-1021. crossref(new window)

Chaudhary SA, Gadhvi KV, Chaudhary AB. Comprehensive review on world herb trade and most utilized medicinal plant. Int J Appl Biol Pharm Tech. 2010;1:510-517.

Chaurasia A, Das D, From 5th World Ayurveda Congress Bhopal MPID. Pa01.07. Evaluation of anti hyperglycemic potential of Piper longum root (linn.) on alloxan induced diabetic mice. Anc Sci Life. 2012;32:S56. crossref(new window)

Chaurasia A, Das D. Evaluation of antihyperglycemic potential of Piper longum root (linn.) on alloxan induced diabetic mice. Adv Pharmacol Toxicol. 2013;14:1-6.

Chempakam B, Parthasarathy VA. Turmeric. In Chemistry of spices. Parthasarathy VA, Chempakam B, Zachariah TJ eds. (Egham, UK; CAB International), pp. 97-123, 2008.

Cherng YG, Tsai CC, Chung HH, Lai YW, Kuo SC, Cheng JT. Antihyperglycemic action of sinapic acid in diabetic rats. J Agric Food Chem. 2013;61:12053-12059. crossref(new window)

Chimakurthy J, Talasila M. Effects of curcumin on pentylenetetrazole-induced anxiety-like behaviors and associated changes in cognition and monoamine levels. Psychol Neurosci. 2010;3:239-244. crossref(new window)

Chiou YS, Wu JC, Huang Q, Shahidi F, Wang YJ, Ho CT, Pan MH. Metabolic and colonic microbiota transformation may enhance the bioactivities of dietary polyphenols. J Func Foods. 2014;7:3-25. crossref(new window)

Choi S, Choi Y, Choi Y, Kim S, Jang J, Park T. Piperine reverses high fat diet-induced hepatic steatosis and insulin resistance in mice. Food Chem. 2013;141:3627-3635. crossref(new window)

Choudhary KM, Mishra A, Poroikov VV, Goel RK. Ameliorative effect of curcumin on seizure severity, depression like behavior, learning and memory deficit in postpentylenetetrazole-kindled mice. Eur J Pharmacol. 2013;704:33-40. crossref(new window)

Choudhary M, Sangha J, Grover K. Conventional and nonconventional edible oils: An indian perspective. J Am Oil Chemists' Soc. 2014;91:179-206. crossref(new window)

Chouhan B, Kumawat RC, Kotecha M, Ramamurthy A, Nathani S. Triphala: A comprehensive ayurvedic review. Int J Res Ayurveda Pharm. 2013;4:612-617. crossref(new window)

Chulet R, Pradhan P. A review on rasayana. Pharmacogn Rev. 2009;3:229-234.

Cicero Bezerra Felipe F, Trajano Sousa Filho J, de Oliveira Souza LE, Alexandre Silveira J, Esdras de Andrade Uchoa D, Rocha Silveira E, Deusdenia Loiola Pessoa O, de Barros Viana GS. Piplartine, an amide alkaloid from piper tuberculatum, presents anxiolytic and antidepressant effects in mice. Phytomedicine. 2007;14:605-612. crossref(new window)

Cnop M, Foufelle F, Velloso LA. Endoplasmic reticulum stress, obesity and diabetes. Trends Mol Med. 2012;18:59-68. crossref(new window)

Colagiuri S. Diabesity: Therapeutic options. Diabetes Obes Metab. 2010;12:463-473. crossref(new window)

Costantini D, Metcalfe NB, Monaghan P. Ecological processes in a hormetic framework. Ecol Lett. 2010;13:1435-1447. crossref(new window)

Cryan JF, Dinan TG. Mind-altering microorganisms: The impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci. 2012;13:701-712. crossref(new window)

D'Souza JJ, D'Souza PP, Fazal F, Kumar A, Bhat HP, Baliga MS. Anti-diabetic effects of the indian indigenous fruit Emblica officinalis gaertn: Active constituents and modes of action. Food Funct. 2014;5:635-644. crossref(new window)

D'Aversa F, Tortora A, Ianiro G, Ponziani F, Annicchiarico B, Gasbarrini A. Gut microbiota and metabolic syndrome. Intern Emerg Med. 2013;8:11-15. crossref(new window)

Dai R, Lim LT. Release of allyl isothiocyanate from mustard seed meal powder. J Food Sci. 2014;79:E47-53. crossref(new window)

Dallman MF, Pecoraro NC, la Fleur SE. Chronic stress and comfort foods: Self-medication and abdominal obesity. Brain Behav Immun. 2005;19:275-280. crossref(new window)

Dasaroju S, Gottumukkala KM. Current trends in the research of Emblica officinalis (amla): A pharmacological perspective. Int J Pharm Sci Rev Res. 2014;24:150-159.

Davenport J, Balch M, Galam L, Girgis A, Hall J, Blagg BS, Matts RL. High-throughput screen of natural product libraries for hsp90 inhibitors. Biology (Basel). 2014;3:101-138.

Davinelli S, Sapere N, Zella D, Bracale R, Intrieri M, Scapagnini G. Pleiotropic protective effects of phytochemicals in alzheimer's disease. Oxid Med Cell Longev. 2012;2012:386527.

Davis C. Evolutionary and neuropsychological perspectives on addictive behaviors and addictive substances: Relevance to the "food addiction" construct. Subst Abuse Rehabil. 2014;5:129-137.

Dembinska-Kiec A, Mykkanen O, Kiec-Wilk B, Mykkanen H. Antioxidant phytochemicals against type 2 diabetes. Br J Nutr. 2008;99:ES109-ES117.

Dhanalakshmi S, Devi RS, Srikumar R, Manikandan S, Thangaraj R. Protective effect of triphala on cold stressinduced behavioral and biochemical abnormalities in rats. Yakugaku Zasshi. 2007;127:1863-1867. crossref(new window)

Dhanalakshmi S, Srikumar R, Manikandan S, Parthasarathy NJ, Devi RS. Antioxidant property of triphala on cold stress induced oxidative stress in experimental rats. J Health Sci. 2006;52:843-847. crossref(new window)

Dietrich MO, Horvath TL. Limitations in anti-obesity drug development: The critical role of hunger-promoting neurons. Nat Rev Drug Discov. 2012;11:675-691. crossref(new window)

Dinan TG, Cryan JF. Regulation of the stress response by the gut microbiota: Implications for psychoneuroendocrinology. Psychoneuroendocrinology. 2012;37:1369-1378. crossref(new window)

Dinkova-Kostova AT, Kostov RV. Glucosinolates and isothiocyanates in health and disease. Trends Mol Med. 2012;18:337-347. crossref(new window)

Doucette CD, Hilchie AL, Liwski R, Hoskin DW. Piperine, a dietary phytochemical, inhibits angiogenesis. J Nutr Biochem. 2013;24:231-239. crossref(new window)

Dragan S, Andrica F, Serban MC, Timar R. Polyphenols-rich natural products for treatment of diabetes. Curr Med Chem. 2015;22:14-22.

Drewnowski A, Gomez-Carneros C. Bitter taste, phytonutrients, and the consumer: A review. Am J Clin Nutr. 2000;72:1424-1435.

Eddouks M, Bidi A, El Bouhali B, Hajji L, Zeggwagh NA. Antidiabetic plants improving insulin sensitivity. J Pharm Pharmacol. 2014;66:1197-1214. crossref(new window)

Epel ES, Lithgow GJ. Stress biology and aging mechanisms: Toward understanding the deep connection between adaptation to stress and longevity. J Gerontol A Biol Sci Med Sci. 2014;69:S10-S16. crossref(new window)

Epel ES. Psychological and metabolic stress: A recipe for accelerated cellular aging? Hormones (Athens). 2009;8:7-22. crossref(new window)

Everard A, Cani PD. Diabetes, obesity and gut microbiota. Best Pract Res Clin Gastroenterol. 2013;27:73-83. crossref(new window)

Fahey JW, Wade KL, Stephenson KK, Chou FE. Separation and purification of glucosinolates from crude plant homogenates by high-speed counter-current chromatography. J Chromatogr A. 2003;996:85-93. crossref(new window)

Farag YM, Gaballa MR. Diabesity: An overview of a rising epidemic. Nephrol Dial Transplant. 2011;26:28-35. crossref(new window)

Farooqui AA. Effect of dietary phytochemicals on metabolic syndrome and neurological disorders. In Metabolic syndrome. (New York, USA; Springer) , pp. 191-234, 2013.

Fasinu PS, Bouic PJ, Rosenkranz B. An overview of the evidence and mechanisms of herb-drug interactions. Front Pharmacol. 2012;3:69.

Fetrow CW, Avila JR. Professional's handbook of complementary and alternative medicines. (Pennsylvania, USA; Springhouse Corporation), 1999.

Fontana L. Modulating human aging and age-associated diseases. Biochim Biophys Acta. 2009;1790:1133-1138. crossref(new window)

Foster JA, McVey Neufeld KA. Gut-brain axis: How the microbiome influences anxiety and depression. Trends Neurosci. 2013;36:305-312. crossref(new window)

Franco R, Cedazo-Minguez A. Successful therapies for alzheimer's disease: Why so many in animal models and none in humans? Front Pharmacol. 2014;5:146.