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Distribution and phytomedicinal aspects of Paris polyphylla Smith from the Eastern Himalayan Region: A review
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  • Journal title : TANG [HUMANITAS MEDICINE]
  • Volume 5, Issue 3,  2015, pp.15.1-15.12
  • Publisher : Association of Humanitas Medicine
  • DOI : 10.5667/tang.2015.0001
 Title & Authors
Distribution and phytomedicinal aspects of Paris polyphylla Smith from the Eastern Himalayan Region: A review
Sharma, Angkita; Kalita, Pallabi; Tag, Hui;
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 Abstract
Comparative studies have established that the North-Eastern (NE) region of India which is a part of the Eastern Himalayan region is affluent in both traditional knowledge based phytomedicine and biodiversity. About 1953 ethno-medicinal plants are detailed from the NE region of India out of which 1400 species are employed both as food and ethnopharmacological resources. Nearly 70% of species diversity has been reported from the two Indian biodiversity hotspots-The Western Ghats and the Eastern Himalayas and these hotspots are protected by tribal communities and their ancient traditional knowledge system. Paris polyphylla Smith belongs to the family Melanthiaceae and is a traditional medicinal herb which is known to cure some major ailments such as different types of Cancer, Alzheimer's disease, abnormal uterine bleeding, leishmaniasis etc. The major phytoconstituents are dioscin, polyphyllin D, and balanitin 7. Phylogeny of Paris was inferred from nuclear ITS and plastid psbA-trnH and trnL-trnF DNA sequence data. Results indicated that Paris is monophyletic in all analyses. Rhizoma Paridis, which is the dried rhizome of Paris polyphylla is mainly used in Traditional Chinese Medicine and its mode of action is known for only a few cancer cell lines. The current review determines to sketch an extensive picture of the potency, diversity, distribution and efficacy of Paris polyphylla from the Eastern Himalayan region and the future validation of its phytotherapeutical and molecular attributes by recognizing the Intellectual Property Rights of the Traditional Knowledge holders.
 Keywords
Biodiversity hotspots;Paris polyphylla;traditional medicinal herb;
 Language
English
 Cited by
 References
1.
Akinmoladun AC, Obuotor EM, Farombi EO. Evaluation of antioxidant and free radical scavenging capacities of some Nigerian indigenous medicinal plants. J Med Food. 2010;13:444-451. crossref(new window)

2.
Albert LS and Kuldip G. Traditional use of medicinal plants by the Jaintia tribes in North Cachar Hills district of Assam, northeast India. J Ethnobiol Ethnomed. 2006;2:33. crossref(new window)

3.
Alderden RA, Hall M, Hambley TW. The discovery and deve lopment of cisplatin. J Chem Educ. 2006;83:728-734. crossref(new window)

4.
Aneja R, Liu M, Yates C, Gao J, Dong X, Zhou B, Vangapandu SN, Zhou J, Joshi HC. Multidrug resistance-associated proteinoverexpressing teniposide-resistant human lymphomas undergo apoptosis by a tubulin-binding agent. Cancer Res. 2008;68:1495-1503. crossref(new window)

5.
Baskin CC, Baskin JM. Seeds, Ecology, Biogeography and Evolution of Dormancy, and Germination. (San Diego, USA: Academic Press), 1998.

6.
Berman JD. Chemotherapy for leishmaniasis: biochemical me chanisms, clinical efficacy, and future strategies. Rev Infect Dis. 1998;10:560-586.

7.
Boulikas T. Molecular mechanisms of cisplatin and its liposomally encapsulated form, $Lipoplatin^{TM}$. $Lipoplatin^{TM}$ as a chemotherapy and antiangiogenesis drug. Cancer Ther. 2007;5:351-376.

8.
Bloor PA, Barker FS, Watts PC, Noyes HA, Kemp SJ. Microsa tellite Libraries by Enrichment. 2001. Available at: http://www.genomics.liv.ac.uk/animal/MICROSAT.PDF. (Accessed January 2002).

9.
Cabral PD, Soares TC, Lima AB, de Miranda FD, Souza FB, Goncalves LS. Genetic diversity in local and commercial dry bean (Phaseolus vulgaris) accessions based on microsatellite markers. Genet Mol Res. 2011;10:140-149. crossref(new window)

10.
Cai Y, Luo Q, Sun M, Corke H. Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer. Life Sci. 2004;74:2157-2184. crossref(new window)

11.
Cheng ZX, Liu BR, Qian XP, Ding YT, Hu WJ, Sun J, Yu LX. Proteomic analysis of anti-tumor effects by Rhizoma Paridis total saponin treatment in HepG2 cells. J Ethnopharmacol. 2008;120:129-137. crossref(new window)

12.
Cheung JY, Ong RC, Suen YK, Ooi V, Wong HN, Mak TC, Fung KP, Yu B, Kong SK. Polyphyllin D is a potent apoptosis inducer in drug-resistant HepG2 cells. Cancer Lett. 2005;217:203-211. crossref(new window)

13.
Chinese Pharmacopoeia Commission. Pharmacopoeia of the People's Republic of China. (Beijing, China: China Medical Science and Technology Press), 2010.

14.
Decrock E, Vinken M, De Vuyst E, Krysko DV, D'Herde K, Vanhaecke T, Vandenabeele P, Rogiers V, Leybaert L. Connexin-related signaling in cell death: to live or let die? Cell Death Differ. 2009;16:524-536. crossref(new window)

15.
Demir K, Bakir M, Sarikamis G and Acunalp S. Genetic diversity of eggplant (Solanum melongena) germplasm from Turkey assessed by SSR and RAPD markers. Genet Mol Res. 2010;9:1568-1576. crossref(new window)

16.
Deng S, Yu B, Hui Y, Yu H, Han X. Synthesis of three diosgenyl saponins:dioscin, polyphyllin D, and balanitin 7. Carbohydr Res. 1999;317:53-62. crossref(new window)

17.
Devkota KP, Khan MT, Ranjit R, Lannang AM, Samreen, Choudhary MI. Tyrosinase inhibitory and antileishmanial constituents from the rhizomes of Paris polyphylla. Nat Prod Res. 2007;21:321-327. crossref(new window)

18.
Dickson TC, Vickers JC. The morphological phenotype of bamyloid plaques and associated neuritic changes in Alzheimer's disease. Neuroscience. 2001;105:99-107. crossref(new window)

19.
Dragland S, Senoo H, Wake K, Holte K, Blomhoff R. Several culinary and medicinal herbs are important sources of dietary antioxidants. J Nutr. 2003;133:1286-1290.

20.
Dutta BK, Dutta PK. Potential of ethnobotanical studies in Northeast India: An Overview. Indian J Tradit Know. 2005;4:7-14.

21.
Ellegren H. Microsatellites: simple sequences with complex evolution. Nat Rev Genet. 2004;5:435-445.

22.
Ely JW, Kennedy CM, Clark EC, Bowdler NC. Abnormal uterine bleeding: a management algorithm. J Am Board Fam Med. 2006;19:590-602. crossref(new window)

23.
Fabricant DS, Farnsworth NR .The value of plants used in traditional medicine for drug discovery. Environ Health Perspect. 2001;109:69-75. crossref(new window)

24.
Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: Globocan 2008. Int J Cancer. 2010;127:2893-2917. crossref(new window)

25.
Fu YL, Zhao ZH, Shan YJ, Cong YW. Inducing effect of total steroid saponins from Paris polyphylla on platelet aggregation in vitro and its potential mechanism. Bulletin Academy Military Med Sci. 2007;31:416-419.

26.
Fujimoto E, Sato H, Shirai S, Nagashima Y, Fukumoto K, Hagiwara H, Negishi E, Ueno K, Omori Y, Yamasaki H, Hagiwara K, Yano T. Connexin32 as a tumor suppressor gene in a metastatic renal cell carcinoma cell line. Oncogene. 2005;4:3684-3690.

27.
Gao LL, Li FR, Jiao P, Yao ST, Sang H, Si YH. Apoptosis of human ovarian cancer cells induced by Paris chinensis dioscin via $Ca^{2+}$- mediated mitochondrion pathway. Asian Pac J Cancer Prev. 2011;12:1361-1366.

28.
Gao LL, Li FR, Jiao P, Yang MF, Zhou XJ, Si YH, Jiang WJ, Zheng TT. Paris chinensis dioscin induces G2/M cell cycle arrest and apoptosis in human gastric cancer SGC-7901 cells. World J Gastroenterol. 2011;17:4389-4395. crossref(new window)

29.
Goncalves LS, Rodrigues R, do Amaral Junior AT, Karasawa M, Sudre CP. Heirloom tomato gene bank: assessing genetic divergence based on morphological, agronomic and molecular data using a Ward-modified location model. Genet Mol Res. 2009;8:364-374. crossref(new window)

30.
Grabley S, Thiericke R. Bioactive agents from natural sources: trends in discovery and application. Adv Biochem Eng Biotechnol. 1999;64:101-154.

31.
Guo L, Su J, Deng BW, Yu ZY, Kang LP, Zhao ZH, Shan YJ, Chen JP, Ma BP, Cong YW. Active pharmaceutical ingredients and mechanisms underlying phasic myometrial contractions stimulated with the saponin extract from Paris polyphylla Sm. var. yunnanensis used for abnormal uterine bleeding. Human Reprod. 2008;23:964-971. crossref(new window)

32.
GuangLie C, WeiShi G, GaiLing H, JianPing C. Effect of paris Saponin on Antitumor and Immune Function in U14 Tumor- Bearing Mice. Afr J Tradit Complement Altern Med. 2013;10:503-507.

33.
Hedge SN. Conservation of Northeast flora. Arunachal Forest News. 2000;18:10-22.

34.
Hung JH, Lu YS, Wang YC, Ma YH, Wang DS, Kulp S.K, Muthusamy N, Byrd JC, Cheng AL, Chen CS. FTY720 induces apoptosis in hepatocellular carcinoma cells through activation of protein kinase C delta signaling. Cancer Res. 2008;68:1204-1212. crossref(new window)

35.
Jackman DM, Yeap BY, Sequist LV, Lindeman N, Holmes AJ, Joshi VA, Bell DW, Huberman MS, Halmos B, Rabin MS, Haber DA, Lynch TJ, Meyerson M, Johnson BE, Janne PA. Exon 19 deletion mutations of epidermal growth factor receptor are associated with prolonged survival in non-small cell lung cancer patients treated with gefitinib or erlotinib. Clin Cancer Res. 2006;12:3908-3914. crossref(new window)

36.
Jain SK, Sumita S. Dictionary of Ethnoveterinary Plants of India. (New Delhi, India: Deep publications), p199, 1999.

37.
Jiang H, Zhao P, Feng J, Su D, Ma S. Effect of Paris saponin I on radiosensitivity in a gefitinib-resistant lung adenocarcinoma cell line. Oncol Lett. 2014;7:2059-2064.

38.
Ji Y, Fritsch PW, Li H, Xiao T, Zhou Z. Phylogeny and Classification of Paris (Melanthiaceae) Inferred from DNA Sequence Data. Ann.Bot. 2006;98:245-256. crossref(new window)

39.
Jun Z. Some bioactive substances from plants of West China. Pure Appl Chem. 1989;61:457-460.

40.
Kala CP. Ethnomedicinal botany of the Apatani in the Eastern Himalayan region of India. J EthnobiolEthnomed. 2005;1:11.

41.
Karthikiyan S. A statistical analysis of flowering plants of India. In: Flora of India Introductory Volume (Part 2), Singh NP, Singh DK, Hajra PK, Sharma BD ed. (Kolkata, India: Botanical Survey of India), pp. 201-217, 2000.

42.
Kim EH, Yoon MJ, Kim SU, Kwon TK, Sohn S, Choi KS. Arsenic trioxide sensitizes human glioma cells, but not normal astrocytes, to TRAIL-induced apoptosis via CCAAT/enhancerbinding protein homologous protein-dependent DR5 upregulation. Cancer Res. 2008;68:266-275. crossref(new window)

43.
Kobayashi N, Toyooka S, Soh J, Yamamoto H, Dote H, Kawasaki K, Otani H, Kubo T, Jida M, Ueno T, Ando M, Ogino A, Kiura K, Miyoshi S. The anti-proliferative effect of heat shock protein 90 inhibitor, 17-DMAG, on non-small-cell lung cancers being resistant to EGFR tyrosine kinase inhibitor. Lung Cancer. 2012;75:161-166. crossref(new window)

44.
Leal AA, Mangolin CA, do Amaral ATJ, Goncalves LS. Efficiency of RAPD versus SSR markers for determining genetic diversity among popcorn lines. Genet Mol Res. 2010;9:9-18. crossref(new window)

45.
Lecanu L, Rammouz G, McCourty A, Sidahmed EK, Greeson J, Papadopoulos V. Caprospinol reduces amyloid deposits and improves cognitive function in a rat model of Alzheimer's disease. Neuroscience. 2010;165:427-435. crossref(new window)

46.
Lee MS, Yuet-Wa JC, Kong SK, Yu B, Eng-Choon VO, Nai-Ching HW, Chung-Wai TM, Fung KP. Effects of Polyphyllin D, a Steroidal Saponin in, in Growth Inhibition of Human Breast Cancer Cells and in Xenograft. Cancer Biol Ther. 2005;4:1248-1254. crossref(new window)

47.
Liang SY, Soukup VG, Paris L. Flora of China Volume 24 Flagellariceae through Marantaceae. Wu ZY, Raven PH ed. (Beijing, China: Science Press and St Luis, USA: Bontanical Garden Press), pp. 88-95, 2000.

48.
Li B, Yu B, Hui Y, Li M, Han X, Fung KP. An improved synthesis of the saponin, polyphyllin D. Carbohydr Res. 2001:331:1-7. crossref(new window)

49.
Li FR, Jiao P, Yao ST, Sang H, Qin SC, Zhang W, Zhang YB, Gao LL. Paris polyphylla Smith Extract Induces Apoptosis and Activates Cancer Suppressor Gene Connexin26 Expression. Asia Pac J Cancer Prev. 2012;13:205-209. crossref(new window)

50.
Long CL, Li H, Ouyang ZQ, Yang XY, Li Q, Trangmar B. Strategies for agrobiodiversity conservation and promotion: a case from Yunnan, China. Biodivers Conserv. 2003;12:1145-1156. crossref(new window)

51.
Mann J. Natural products in cancer chemotherapy: past, present and future. Nat Rev Cancer. 2002;2:143-148. crossref(new window)

52.
Martin PE, Evans WH. Incorporation of connexins into plasma membranes and gap junctions. Cardiovasc Res. 2004;62:378-387. crossref(new window)

53.
Miller KI, Qing C, Sze DMY, Neilan BA. Investigation of the Biosynthetic Potential of Endophytes in Traditional Chinese Anticancer Herbs. PLoS One. 2012;7:e35953. crossref(new window)

54.
Miyamoto J, Kurita S, Gu ZJ, Li H. C-Banding patterns in eighteen taxa of the genus Paris sensu Li, Liliaceae. Cytologia. 1992:57;181-194. crossref(new window)

55.
Mochida K, Shinozaki K. Advances in omics and bioinforma tics tools for systems analysis of plant functions. Plant Cell Physiol. 2011;52:2017-2038. crossref(new window)

56.
Morgan DO. Principles of CDK regulation. Nature. 1995;374:131-134. crossref(new window)

57.
Myers N, Muttermeier RA, Muttermeier CG, da Fonseca GAB, Kent J. Biodiversity hotspots for conservation priorities. Nature. 2000;403:853-858. crossref(new window)

58.
Nambara E, Nonogaki H. Seed biology in the 21st century: perspectives and new directions. Plant Cell Physiol. 2012;53:1-4. crossref(new window)

59.
Namsa ND, Tag H, Mandal M, Kalita P, Das AK. An ethnobotanical study of traditional anti-inflammatory plants used by the Lohit Community of Arunachal Pradesh, India. J Ethnopharmacol. 2009;125:234-245. crossref(new window)

60.
Norbury C, Nurse P. Animal cell cycles and their control. Annu Rev Biochem. 1992;61:441-470. crossref(new window)

61.
Oehler MK, MacKenzie I, Kehoe S, Rees MC. Assessment of abnormal bleeding in menopausal women: an update. J Br Menopause Soc. 2003;9:117-121. crossref(new window)

62.
Oliveira EC, Amaral Junior AT, Goncalves LS, Pena GF, Freitas Junior SP, Ribeiro RM, Pereira MG. Optimizing the efficiency of the touchdown technique for detecting intersimple sequence repeat markers in corn (Zea mays). Genet Mol Res. 2010;9:835-842. crossref(new window)

63.
Oosterhout CV, Hutchinson WF, Wills DPM, Shipley P (2004). Micro-Checker: software for identifying and correcting genotyping errors in microsatellite data. Mol Ecol Notes. 2004;4:535-538. crossref(new window)

64.
Oyamada M, Oyamada Y, Takamatsu T. Regulation of connexin expression. Biochimica et Biophysica Acta. 2005;1719:6-23. crossref(new window)

65.
Ozen T, Collu Z, Korkmaz H. Antioxidant Properties of Urtica pilulifera Root, Seed, Flower, and Leaf Extract. J Med Food. 2010;13:1224-1231. crossref(new window)

66.
Patwardhan B. Drug Discovery and Development: Traditional Medicine and Ethnopharmacology. (New Delhi, India: New India Publishing Agency), pp.7-322, 2007.

67.
Pande PC, Tiwari L, Pande HC. Ethnoveterinary plants of Uttaranchal- A review. Indian J Tradit Know. 2007;6:444-458.

68.
Qi J, Zheng N, Zhang B, Sun P, Hu S, Xu W, Ma Q, Zhao T, Zhou L, Qin M, Li X. Mining genes involved in the stratification of Paris Polyphylla seeds using high-throughput embryo Transcriptome sequencing. BMC Genomics. 2013;14:358. crossref(new window)

69.
Raju J, Rao CV. Diosgenin, a Steroid Saponin Constituent of Yams and Fenugreek: Emerging Evidence for Applications in Medicine. In Bioactive Compounds in Phytomedicine. Rasooli I ed. (Rijeka, Croatia: InTech), 2012.

70.
Ram VJ, Nath M. Current status of Chemotherapy of Leishmaniasis. Curr Med Chem. 1996;3:303-316.

71.
Rastogi P, Mehrotra BN. Compendium of Indian Medicinal Plants. (New Delhi, India: National Institute of Science and Communication), pp. 479-480, 1993.

72.
Ravipati AS, Zhang L, Koyyalamudi SR, Jeong SC, Reddy N, Bartlett J, Smith PT, Shanmugam K, Munch G, Wu MJ, Satyanarayanan M, Vysetti B. Antioxidant and anti-inflamma tory activities of selected Chinese medicinal plants and their relation with antioxidant content. BMC Complem Altern M. 2012;12:173. crossref(new window)

73.
Roa AC, Chavarriaga-Aguirre P, Duque MC, Maya MM, Bonierbale MW, Iglesias C, Tohme J. Cross-species amplifica tion of cassava (Manihot esculenta) (Euphorbiaceae) microsate llites: allelic polymorphism and degree of relationship. Am J Bot. 2000;87:1647-1655. crossref(new window)

74.
Riely GJ, Pao W, Pham D, Li AR, Rizvi N, Venkatraman ES, Zakowski MF, Kris MG, Ladanyi M, Miller VA. Clinical course of patients with non-small cell lung cancer and epidermal growth factor receptor exon 19 and exon 21 mutations treated with gefitinib or erlotinib. Clin Cancer Res. 2006;12:839-844. crossref(new window)

75.
Schlotterer C. The evolution of molecular markers - just a matter of fashion? Nat Rev Genet. 2004;5:63-69. crossref(new window)

76.
Schrager S. Abnormal uterine bleeding associated with hormonal contraception. Am Fam Physician. 2002;65:2073-2081.

77.
Sharma PC, Grover A, Kahl G. Mining microsatellites in eukaryotic genomes. Trends Biotechnol. 2007;25:490-498. crossref(new window)

78.
Shino M, Watanabe Y, Umezawa K. Synthesis of N-substituted N-nitrosohydroxylamines as inhibitors of mushroom tyrosinase. Bioorgan Med Chem. 2001;9:1233-1240. crossref(new window)

79.
Shoemaker M, Hamilton B, Dairkee SH, Cohen I, Campbell MJ. In vitro anticancer activity of twelve Chinese medicinal herbs. Phytother Res. 2005;9:649-651.

80.
Sordella R, Bell DW, Haber DA, Settleman J. Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways. Science. 2004;305:1163-1167. crossref(new window)

81.
Sutter AP, Fechner H. Gene therapy for gastric cancer: is it promising? World J Gastroenterol. 2006;12:380-387.

82.
Tag H, Das AK. Ethnobotanical notes on Hill Miri (Nyishi) tribes of Arunachal Pradesh. Indian J Tradit Know. 2004;3:80-85.

83.
Tag H, Das AK, Pallabi H, Singh RK, Palit G. Botanical resources used in traditional wood carving industry among the Wancho tribe of Arunachal Pradesh. Indian J Tradit Know. 2008;7:148-156.

84.
Tag H. Mainstreaming Conservation and Sustainable use of Medicinal Plant Diversity in Three Indian States. Final Technical Report submitted to UNDP Cell. (New Delhi, India: Govt. of India), pp. 1-124, 2012.

85.
Tag H, Kalita P, Das AK. Biodiversity, Traditional Knowledge, IPR and rationalization of Traditional Phytomedicine in the Context of North East India. In Traditional Phytotherapy. Buragohain J ed. (New Delhi, India: Daya publishing house), pp. 27-46, 2013.

86.
Tag H, Murtem G, Das AK, Singh RK. Diversity and distribution of ethno-medicinal plants used by the Adi Tribe in East Siang District of Arunachal Pradesh, India. Pleione. 2008;2:123-136.

87.
Takhtajan A. A revision of Daiswa (Trilliaceae). Brittonia. 1983;35:255-270. crossref(new window)

88.
Tanaka M, Grossman HB. Connexin26 induces growth suppression, apoptosis and increased efficacy of doxorubicin in prostate cancer cells. Oncol Rep. 2004;11:537-541.

89.
Talhouk R, Karam C, Fostok S, El-Jouni W, Barbour E. Antiinflammatory bioactivities in plant extracts. J Med Food. 2007;10:1-10. crossref(new window)

90.
Terry RD, Masliah E, Salmon DP, Butters N, DeTeresa R, Hill R, Hansen LA, Katzman R. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Annal Neurol. 1991;30:572-580. crossref(new window)

91.
Tiwari JK, Ballabha R, Tiwari P. New York Science Journal. 2010;3:123-126.

92.
Tohda C, Kuboyama T & Komatsu K. Search for natural products related to regeneration of the neuronal network. Neurosignals. 2005;14:34-45. crossref(new window)

93.
Tohda C, Urano T, Umezaki M, Nemere I, Kuboyama T. Diosgenin is an exogenous activator of 1,25D3- MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice. Sci Rep. 2012;2:535.

94.
Uprety Y, Asselin H, Boon E, Yadav S, Shrestha KK. Indigenous use and bio-efficacy of medicinal plants in the Rasuwa District, Central Nepal. J Ethnobiol Ethnomed. 2010;6:3. crossref(new window)

95.
Valdiya KS. Himalaya: Emergence and evolution. University Press Publ., Hyderabad, pp. 139, 2001.

96.
Verma P, Mathur AK, Jain SP, Mathur A. In Vitro Conservation of Twenty-three Overexploited Medicinal Plants Belonging to The Indian Sub-Continent. Sci World J. 2012;929650:10.

97.
Vieira EA, Carvalho FIF, Bertan I, Kopp MM, Zimmer PD, Benin G, Silva JAG, Hartwig I, Malone G, Oliveira AC. Association between genetic distances in wheat (Triticum aestivum L.) as estimated by AFLP and morphological markers. Genet Mol Biol. 2007;30:392-399.

98.
Wang C, Schuller Levis GB, Lee EB, Levis WR, Lee DW, Kim BS, Park SY, Park E. Platycodin D and D3 isolated from the root of Platycodon grandiflorum modulate the production of nitric oxide and secretion of TNF-[alpha] in activated RAW 264.7 cells. Int J Immunopharmacol. 2004;4:1039-1049. crossref(new window)

99.
Wang L, Jia C, Yu Z, Liu X, Kang L, Cong Y, Shan Y, Zhao Z, Ma B, Cong Y. Pennogenin Tetraglycoside Induces Rat Myometrial Contraction and MLC20 Phosphorylation via PLCIP3 and RhoA/Rho Kinase Signaling Pathways. PLoS ONE. 2012;7:e51536. crossref(new window)