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Comparative investigation into the anti-ulcer activity of virgin coconut oil and coconut oil in pylorous ligated animal model
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  • Journal title : TANG [HUMANITAS MEDICINE]
  • Volume 5, Issue 4,  2015, pp.28.1-28.6
  • Publisher : Association of Humanitas Medicine
  • DOI : 10.5667/tang.2015.0030
 Title & Authors
Comparative investigation into the anti-ulcer activity of virgin coconut oil and coconut oil in pylorous ligated animal model
Selvarajah, Malarvili; Ahmad, Zuraini; Zakaria, Zainul Amiruddin; Chiong, Hoe Siong; Yong, Yoke Kin; Long, Kamariah; Hakim, Muhammad Nazrul;
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 Abstract
This current study investigated the anti-ulcer activity of 2 types of virgin coconut oil (VCO-A and VCO-B) and coconut oil (CO). Sprague-Dawley of male rats divided into 6 groups and each group consisted of ten rats. Rats were then treated with either VCO or CO and then were then anaesthetized and pyloric ligation was performed. The anaesthesia was discontinued and the animal usually recovered consciousness within less than an hour. Three hours later, the animal was then again anaesthetized and sacrificed with chloroform. Stomach removed and its content subjected to measurement of volume and pH. The results revealed VCO-B and VCO-A (100%) significantly inhibited (p < 0.001) the volume of gastric juice secreted by the control rats by 66.81% and 51.53%, respectively. Followed by CO 42.80%. While the inhibition of gastric juice for positive control rats which treated with ranitidine (100 mg/kg) was only 22.38%. The total acid output was reduced by the oils to 70.80%, 74.16% and 40.45% for VCO-A, VCO-B and CO respectively compared to control group. Ranitidine reduced the total acid output by 34.83%. In conclusion, prevention of gastric lesions in rats by VCO was found to increase the mucous and decrease the acid volume, total acid contents and ulcer scoring. The treatment of VCO affects the all parameters that influence the initiation and perpetuation of ulceration.
 Keywords
virgin coconut oil;coconut oil;ranitidine;ulcer;pyloric ligation;mucous secretion;
 Language
English
 Cited by
 References
1.
Amang PA, Tan PV, Patamaken SA, Mefe MN. Cytoprotective and antioxidant effects of the methanol extract of Eremomastax speciosa in rats. Afr J Tradit Complement Altern Med. 2013;11:165-171.

2.
Bandyopadhyay D, Biswas K, Bhattacharyya M, Reiter RJ, Banerjee RK. Gastric toxicity and mucosal ulceration induced by oxygen-derived reactive species, protection by melatonin. Curr Mol Med. 2001;1:501-513. crossref(new window)

3.
Bandyopadhyay D, Biswas K, Bhattacharyya M, Reiter RJ, Banerjee RK. Involvement of reactive oxygen species in gastric ulceration, protection by melatonin. Indian J Exp Biol. 2002;40:693-705.

4.
Bighetti AE, Antonio MA, Kohn LK, Rehder VL, Foglio MA, Possenti A, Vilela L, Carvalho JE. Antiulcerogenic activity of a crude hydroalcoholic extract and coumarin isolated from Mikania laevigata Schultz Bip. Phytomedicine. 2005;12:72-77. crossref(new window)

5.
Borelli F, Izzo AA. The plant kingdom as a source of anti-ulcer remedies. Phytother Res. 2000;14:581-591. crossref(new window)

6.
Brodie DA, Knaff PG. The mechanism of the inhibition of gastric secretion produced by esophageal ligation in the pylorus-ligateg rat. Gatroenterology. 1966;50:787-795.

7.
Brown GG. An introduction to Histotechnology. 1st ed. (NY, USA: Appleton-Century-Crofts), pp.293-308, 1978.

8.
Calam J, Baron JH. Pathophysiology of duodenal and gastric ulcer and gastric cancer. BMJ. 2001;323:980-982. crossref(new window)

9.
Che Man YB, Abdul Karim MIB, Teng CT. Extraction of coconut oil with Lactobacillus plantarum 1041 IAM. Journal of the American Oil Chemists Society. 1997;74:1115-1119. crossref(new window)

10.
Corne SJ, Morrisey SM, Woods RJ. A method for the quantitative estimation of gastric barrier mucus. J Physiol. 1974;242:116-117.

11.
de Andrade SF, Lemos M, Comunello E, Noldin VF, Filho VC, Niero R. Evaluation of the antiulcerogenic activity of Maytenus robusta (Celastraceae) in different experimental ulcer models. J Ethnopharmacol. 2007;113:252-257. crossref(new window)

12.
Desal JK, Goyal RK, Parmar NS. Pathogenesis of peptic ulcer disease and current trends in therapy .Indian J Physiol Pharmacol. 1997;41:3-15.

13.
Devaraj VC, Gopala Krishna B, Viswanatha GL, Satya Prasad V, Vinay Babu SN. Protective effect of leaves of Raphinus sativus Linn on experimentally induced gastric ulcers in rats. Saudi Pharm J. 2011;19:171-176. crossref(new window)

14.
Hakanson R, Hedenbro J, Liedberg G, Sundler F, Vallgren S. Mechanisms of gastric acid secretion after pylorus and oesophagus ligation in the rat. J Physiol. 1980;305:139-149. crossref(new window)

15.
Hakanson R, Lieburg G. The role of endogenous gastrin in the activation of gastric histidine decaboxylase in the rat. Effect of antrectomy and vagal denervation. Eur J Pharmacol. 1970;12:99-103. crossref(new window)

16.
Jain KS, Shah AK, Bariwal J, Shelke SM, Kale AP, Jagtap JR, Bhosale AV. Recent advances in proton pump inhibitors and management of acid-peptic disorders. Bioorg Med Chem. 2007;15:1181-1205. crossref(new window)

17.
Minano JF, Sarrano JS, Pascual J, Sancibrian M. Effects of GABA on gastric acid secretion and ulcer formation in rats. Life Sci. 1987;41:1651-1658. crossref(new window)

18.
Mota KS, Dias GE, Pinto ME, Luiz-Ferreira A, Souza-Brito AR, Hiruma-Lima CA, Barbosa-Filho JM, Batista LM. Flavonoids with gastroprotective activity. Molecules. 2009;14:979-1012. crossref(new window)

19.
Mukherjee M, Bhaskaran N, Srinath R, Shivaprasad HN, Allan JJ, Shekhar D, Agarwal A. Anti-ulcer and antioxidant activity of GutGard. Indian J Exp Biol. 2010;48:269-274.

20.
Piper DW, Stiel DD. Pathogenesis of chronic peptic ulcer, current thinking and clinical implications. Dig Dis Sci. 1986; 32:1395-1401.

21.
Rang HP, Dale MM, Ritter JM, Flower RJ, Henderson G. Rang and Dale’s Pharmacology. 7th ed. (Edinburgh, Scotland: Churchill Livingstone), 2012.

22.
Salim AS. Removing oxygen derived free radicals stimulates healing of ethanol induced erosive gastritis in the rat. Digestion. 1990;47:24-28. crossref(new window)

23.
Seow CC, Gwee CN. Coconut milk: chemistry and technology. International Journal of Food Science and Technology. 1997; 32:189-201. crossref(new window)

24.
Shay H, Komarov SA, Gruenstein M. Effects of vagotomy in the rat. Arch Surg. 1949;59:210-226. crossref(new window)

25.
Shay H, Sun DC, Gruenstein M. A quantitative method for measuring spontaneous gastric secretion in the rat. Gastroenterology. 1954;26:906-913.

26.
Susan G, Sathimoorthy A, Sathiamoorthy SS. Effect of alpha tocopherol on gastric ulcers induced by pylorus ligation in rats. Indian J Pharmacol. 1999;31:431-433.

27.
Tariq M. Gastric anti-ulcer and cytoprotective effect of Vitamin E in rats. Res Cummun Chem Pathol Pharmacol. 1998;60:87-96.