Advanced SearchSearch Tips
Characterizations of nano-zinc doped hydroxyapatite to use as bone tissue engineering
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Characterizations of nano-zinc doped hydroxyapatite to use as bone tissue engineering
Abdel-Ghany, Basma E.; Abdel-Hady, Bothaina M.; El-Kady, Abeer M.; Beheiry, Hanan H.; Guirguis, Osiris W.;
Contamination by bacterial strands is a major problem after bone replacement surgeries, so there is a great need to develop low cost biocompatible antibacterial bioactive scaffolds to be used in bone tissue engineering. For this purpose, nano-zinc doped hydroxyapatite with different zinc-concentrations (5, 10 and 15 mol%) was successfully prepared by the wet chemical precipitation method. The prepared powders were used to form porous scaffolds containing biodegradable Ca-cross-linked alginate (5%) in order to enhance the properties of alginate scaffolds. The scaffolds were prepared using the freeze-gelation method. The prepared powders were tested by X-ray diffraction; transmission electron microscope and Fourier transform infrared analyses, while the prepared scaffolds were investigated by Fourier transform infrared analyses, thermogravimetric analyses and measurement of the antibacterial properties. Best results were obtained from scaffold containing 15% mol zinc-doped hydroxyapatite powders and 5% alginate concentration with ratio of 70:30.
bioceramics;nano-zinc doped hydroxyapatite;scaffolds;nanostructure;antimicrobial activity;
 Cited by
Chen, X., Tang, Q.L., Zhu, Y.J., Zhu, C.I. and Feng, X.P. (2012), "Synthesis and antibacterial property of zinc loaded hydroxyapatite nanorods", Mater. Lett., 89, 233-235. crossref(new window)

Cho, S.H., Oh, S.H. and Lee, J.H. (2005), "Fabrication and characterization of porous alginate/polyvinyl alcohol hybrid scaffolds for 3D cell culture", J. Biomater. Sci., Polym. Ed., 16(8), 933-947. crossref(new window)

Chung, R.J., Hsieh, M.F., Huang, K.C., Perng, L.H., Chou, F.I. and Chin, T.S. (2005), "Anti-microbial hydroxyapatite particles synthesized by a sol-gel route", J. Sol-gel Sci. Tech., 33(2), 229-239. crossref(new window)

Ho, M.H., Kuo, P.Y., Hsieh, H.J., Hsien, T.Y., Hou, L.T., Lai, J.Y. and Wang, D.M. (2004), "Preparation of porous scaffolds by using freeze-extraction and freeze-gelation methods", Biomater., 25(1), 129-138. crossref(new window)

Jin, H.H., Lee, C.H., Lee, W.K., Lee, J.K., Park, H.C. and Yoon, S.Y. (2008), "In-situ formation of the hydroxyapatite/chitosan-alginate composite scaffolds", Mater. Lett., 62(10), 1630-1633. crossref(new window)

Kumar, G.S., Thamizhavel, A., Yokogawa, Y., Kalkura, S.N. and Girija, E.K. (2012), "Synthesis, characterization and in vitro studies of zinc and carbonate co-substituted nano-hydroxyapatite for biomedical applications", Mater. Chem. Phys., 134(2), 1127-1135. crossref(new window)

Lu, L. and Mikos, A.G. (1996), "The importance of new processing techniques in tissue engineering", Mrs. Bull., 21(11), 28-32.

Ma, M.G., Zhu, Y.J. and Chang, J. (2006), "Monetite formed in mixed solvents of water and ethylene glycol and its transformation to hydroxyapatite", J. Phys. Chem. B, 110(29), 14226-14230. crossref(new window)

Maguire, J.K., Cosca, M.F. and Lynch, M.H. (1987), "Problems in implantation", Clin. Orthop., 216, 213-223.

Maquet, V. and Jerome, R. (1997), "Design of macroporous biodegradable polymer scaffolds for cell transplantation", Mater. Sci. Forum, 250, 15-42. crossref(new window)

Miyaji, F., Kono, Y. and Suyama, Y. (2005), "Formation and structure of zinc-substituted calcium hydroxyapatite", Mater. Res. Bull., 40(2), 209-220. crossref(new window)

Mourino, V. and Boccaccini, A.R. (2010), "Review: Bone tissue engineering therapeutics: controlled drug delivery in three-dimensional scaffolds", J. Royal Soc. Interface, 7, 209-227. crossref(new window)

Ninan, N., Muthiah, M., Park, I.K., Elain, A., Thomas, S. and Grohens, Y. (2013), "Pectin/carboxymethyl cellulose/microfibrillated cellulose composite scaffolds for tissue engineering", Carbohyd. Polym., 98(1), 877-885. crossref(new window)

Ren, F., Xin, R., Ge, X. and Leng, Y. (2009), "Characterization and structural analysis of zinc-substituted hydroxyapatites", Acta Biomater., 5(8), 3141-3149. crossref(new window)

Rho, J.Y., Kuhn-Spearing, L. and Zioupos, P. (1998), "Mechanical properties and the hierarchical structure of bone", Med. Eng. Phys., 20(2), 92-102. crossref(new window)

Ribeiro, C.C., Barrias, C.C. and Barbosa, M.A. (2004), "Calcium phosphate-alginate microspheres as enzyme delivery matrices", Biomater., 25(18), 4363-4373. crossref(new window)

Segal, L.G.J.M.A., Creely, J.J., Martin, A.E. and Conrad, C.M. (1959), "An empirical method for estimating the degree of crystallinity of native cellulose using the X-ray diffractometer", Textile Res. J., 29(10), 786-794. crossref(new window)

Sowjanya, J.A., Singh, J.,Mohita, T., Sarvanan, S.,Moorthi, A., Srinivasan, N. and Selvamurugan, N. (2013), "Biocomposite scaffolds containing chitosan/alginate/nano-silica for bone tissue engineering", Coll. Surf. B: Biointerf., 109, 294-300. crossref(new window)

Sutha, S., Karunakaran, G. and Rajendran, V. (2013), "Enhancement of antimicrobial and long-term biostability of the zinc-incorporated hydroxyapatite coated 316L stainless steel implant for biomedical application", Ceram. Int., 39(5), 5205-5212. crossref(new window)

Tateishi, T., Chen, G., Ushida, T., Murata, T., Mizuno, S., Lewandrowski, K.U., Wise, D., Trantolo, D., Gresser, J., Yaszemski, M. and Altobelli, D. (2002), Tissue Engineering and Biodegradable Equivalents-Scientific and Clinical Applications, Marcel Dekker Inc., New York.

Tin-Oo, M.M., Gopalakrishnan, V., Samsuddin, A.R., Al Salihi, K.A. and Shamsuria, O. (2007), "Antibacterial property of locally produced hydroxyapatite", Arch. Orofacial Sci., 2, 41-44.

Whang, K., Tsai, D.C., Nam, E.K., Aitken, M., Sprague, S.M., Patel, P.K. and Healy, K.E. (1998), "Ectopic bone formation via rhBMP-2 delivery from porous bioabsorbable polymer scaffolds", J. Biomed. Mater. Res., 42, 491-499. crossref(new window)

Xia, Z., Yu, X., Jiang, X., Brody, H.D., Rowe, D.W. and Wei, M. (2013), "Fabrication and characterization of biomimetic collagen-apatite scaffolds with tunable structures for bone tissue engineering", Acta Biomater., 9(7), 7308-7319. crossref(new window)

Xiao, X., Liu, R., Chen, C. and Huang, L. (2008), "Structural characterization of zinc-substituted hydroxyapatite prepared by hydrothermal method", J. Mater. Sci.: Mater. Medicine, 19(2), 797-803.

Xu, F.L., Li, Y.B., Han, J. and Lv, G.Y. (2005), "Biodegradable porous nano-hydroxyapatite/alginate scaffold", Mater. Sci. Forum, 486, 189-192.

Zhang, S.M., Cui, F.Z., Liao, S.S., Zhu, Y. and Han, L. (2003), "Synthesis and biocompatibility of porous nano-hydroxyapatite/collagen/alginate composite", J.Mater. Sci: Mater. Med., 14(7), 641-645.