JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Effects of alfaxalone on echocardiographic examination in healthy dogs
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Effects of alfaxalone on echocardiographic examination in healthy dogs
Kim, Ye-Won; Kim, Tae-Jun; Hyun, Changbaig;
  PDF(new window)
 Abstract
This study evaluated the effects of alfaxalone (3 mg/kg, intravenously) on echocardiographic examination in healthy dogs using echocardiography. Six adult Beagle dogs were used for this study. Left ventricular dimensions with systolic indexes, trans-blood flow at all cardiac valvular annulus and trans-mitral tissue Doppler values were measured from routine transthoracic echocardiography. Although the changes were not statistically significant, heart rate, left ventricular end-systolic diameter, left ventricular end-diastolic diameter, peak velocities of tricuspid A-wave and transpulmonic flow were increased after alfaxalone induction, while systolic blood pressure, fractional shortening, left ventricular ejection fraction, peak velocities of mitral E-wave, mitral A wave, tricuspid E-wave, transaortic flow and medial e`-, a`- and s`-peaks decreased after alfaxalone induction. No dogs showed hypoxemia during sedation, regardless of intubation and oxygen supply. Although alfaxalone showed mild cardiovascular depression, this protocol could be a good alternative sedative protocol for echocardiographic examination in healthy dogs because the cardiovascular depression was statistically and clinically insignificant. However, further studies in dogs with heart diseases should be conducted to confirm these findings after alfaxalone induction.
 Keywords
alfaxalone;canine;cardiac function;cardiovascular depression;left ventricle;
 Language
English
 Cited by
 References
1.
Ambros B, Duke-Novakovski T, Pasloske KS. Comparison of the anesthetic efficacy and cardiopulmonary effects of continuous rate infusions of alfaxalone-2-hydroxypropyl-$\beta$-cyclodextrin and propofol in dogs. Am J Vet Res 2008, 69, 1391-1398. crossref(new window)

2.
Herbert GL, Bowlt KL, Ford-Fennah V, Covey-Crump GL, Murrell JC. Alfaxalone for total intravenous anaesthesia in dogs undergoing ovariohysterectomy: a comparison of premedication with acepromazine or dexmedetomidine. Vet Anaesth Analg 2013, 40, 124-133. crossref(new window)

3.
Karas AZ. Sedation and chemical restraint in the dog and cat. Clin Tech Small Anim Pract 1999, 14, 15-26. crossref(new window)

4.
Lambert JJ, Belelli D, Peden DR, Vardy AW, Peters JA. Neurosteroid modulation of GABAA receptors. Prog Neurobiol 2003, 71, 67-80. crossref(new window)

5.
Maney JK, Shepard MK, Braun C, Cremer J, Hofmeister EH. A comparison of cardiopulmonary and anesthetic effects of an induction dose of alfaxalone or propofol in dogs. Vet Anaesth Analg 2013, 40, 237-244. crossref(new window)

6.
Muir W, Lerche P, Wiese A, Nelson L, Pasloske K, Whittem T. Cardiorespiratory and anesthetic effects of clinical and supraclinical doses of alfaxalone in dogs. Vet Anaesth Analg 2008, 35, 451-462. crossref(new window)

7.
O'Hagan B, Pasloske K, McKinnon C, Perkins N, Whittem T. Clinical evaluation of alfaxalone as an anaesthetic induction agent in dogs less than 12 weeks of age. Aust Vet J 2012, 90, 346-350. crossref(new window)

8.
Pasloske K, Sauer B, Perkins N, Whittem T. Plasma pharmacokinetics of alfaxalone in both premedicated and unpremedicated Greyhound dogs after single, intravenous administration of Alfaxan at a clinical dose. J Vet Pharmacol Ther 2009, 32, 510-513. crossref(new window)

9.
Psatha E, Alibhai HI, Jimenez-Lozano A, Armitage-Chan E, Brodbelt DC. Clinical efficacy and cardiorespiratory effects of alfaxalone, or diazepam/fentanyl for induction of anaesthesia in dogs that are a poor anaesthetic risk. Vet Anaesth Analg 2011, 38, 24-36. crossref(new window)

10.
Quiros Carmona S, Navarrete-Calvo R, Granados MM, Dominguez JM, Morgaz J, Fernandez-Sarmiento JA, Munoz-Rascon P, Gomez-Villamandos RJ. Cardiorespiratory and anaesthetic effects of two continuous rate infusions of dexmedetomidine in alfaxalone anaesthetized dogs. Res Vet Sci 2014, 97, 132-9. crossref(new window)

11.
Rishniw M. Sedation protocols for echocardiography. Veterinary Information Networks, Davis, 2010.

12.
Rodriguez JM, Munoz-Rascon P, Navarrete-Calvo R, Gomez-Villamandos RJ, Dominguez Perez JM, Fernandez Sarmiento JA, Quiros Carmona S, Granados Machuca MM. Comparison of the cardiopulmonary parameters after induction of anaesthesia with alphaxalone or etomidate in dogs. Vet Anaesth Analg 2012, 39, 357-65. crossref(new window)

13.
Sahn DJ, DeMaria A, Kisslo J, Weyman A. Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. Circulation 1978, 58, 1072-1083. crossref(new window)

14.
Seo JI, Han SH, Choi R, Han J, Lee L, Hyun C. Cardiopulmonary and anesthetic effects of the combination of butorphanol, midazolam and alfaxalone in Beagle dogs. Vet Anaesth Analg 2015, 42, 304-308. crossref(new window)

15.
Sousa MG, Carareto R, De-Nardi AB, Brito FL, Nunes N, Camacho AA. Effects of isoflurane on echocardiographic parameters in healthy dogs. Vet Anaesth Analg 2008, 35, 185-190. crossref(new window)

16.
Thomas WP, Gaber CE, Jacobs GJ, Kaplan PM, Lombard CW, Moise NS, Moses BL. Recommendations for standards in transthoracic two-dimensional echocardiography in the dog and cat. J Vet Intern Med 1993, 7, 247-252. crossref(new window)