JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Drug-induced blood cell dyscrasia associated with phenobarbital administration in a dog
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Drug-induced blood cell dyscrasia associated with phenobarbital administration in a dog
Jung, Han-Byeol; Kang, Min-Hee; Park, Hee-Myung;
  PDF(new window)
 Abstract
A 13-year-old, spayed, female Chihuahua dog was referred for evaluation of fever, lethargy, and dyspnea. Hematologic evaluation revealed severe neutropenia, thrombocytopenia, and mild anemia. The dog had been undergoing phenobarbital therapy for the past 7 weeks because of generalized seizures due to meningoencephalomyelitis of unknown etiology. After ruling out other possible causes of cytopenias, a tentative diagnosis was made of drug-induced blood cell dyscrasia. The neutropenia and thrombocytopenia resolved after discontinuation of phenobarbital (8 days and 15 days after discontinuation, respectively). This is the first case report in Korea to demonstrate blood dyscrasia associated with idiosyncratic adverse effects of phenobarbital.
 Keywords
leukopenia;neutropenia;phenobarbital;thrombocytopenia;
 Language
English
 Cited by
 References
1.
Benichou C, Solal Celigny P. Standardization of definitions and criteria for causality assessment of adverse drug reactions. Drug-induced blood cytopenias: report of an international consensus meeting. Nouv Rev Fr Hematol 1991, 33, 257-262.

2.
Gaskill CL, Miller LM, Mattoon JS, Hoffmann WE, Burton SA, Gelens HCJ, Ihle SL, Miller JB, Shaw DH, Cribb AE. Liver histopathology and liver and serum alanine aminotransferase and alkaline phosphatase activities in epileptic dogs receiving phenobarbital. Vet Pathol 2005, 42, 147-160. crossref(new window)

3.
Greenwood RS. Adverse effects of antiepileptic drugs. Epilepsia 2000, 41, S42-52. crossref(new window)

4.
Hauptman JG, Walshaw R, Olivier NB. Evaluation of the sensitivity and specificity of diagnostic criteria for sepsis in dogs. Vet Surg 1997, 26, 393-397. crossref(new window)

5.
Jacobs G, Calvert C, Kaufman A. Neutropenia and thrombocytopenia in three dogs treated with anticonvulsants. J Am Vet Med Assoc 1998, 212, 681-684.

6.
Khoutorsky A, Bruchim Y. Transient leucopenia, thrombocytopenia and anaemia associated with severe acute phenobarbital intoxication in a dog. J Small Anim Pract 2008, 49, 367-369. crossref(new window)

7.
Maddison JE, Page SW. Adverse drug reactions. In: Maddison JE, Page SW, Church D (eds.). Small Animal Clinical Pharmacology. 2nd ed. pp. 41-52, Saunders, Philadelphia, 2008.

8.
Muller PB, Taboada J, Hosgood G, Partington BP, VanSteenhouse JL, Taylor HW, Wolfsheimer KJ. Effects of long-term phenobarbital treatment on the liver in dogs. J Vet Intern Med 2000, 14, 165-171. crossref(new window)

9.
Podell M. Antiepileptic drug therapy. Clin Tech Small Anim Pract 1998, 13, 185-192. crossref(new window)

10.
Vernau KM, LeCouteur RA, Maddison JE. Anticonvulsant drugs. In: Maddison JE, Page SW, Church D (eds.). Small Animal Clinical Pharmacology. 2nd ed. pp. 367-379, Saunders, Philadelphia, 2008.

11.
Verrotti A, Coppola G, Parisi P, Mohn A, Chiarelli F. Bone and calcium metabolism and antiepileptic drugs. Clin Neurol Neurosurg 2010, 112, 1-10. crossref(new window)

12.
Verrotti A, Scaparrotta A, Grosso S, Chiarelli F, Coppola G. Anticonvulsant drugs and hematological disease. Neurol Sci 2014, 35, 983-993. crossref(new window)

13.
Weiss DJ. Bone marrow necrosis in dogs: 34 cases (1996-2004). J Am Vet Med Assoc 2005, 227, 263-267. crossref(new window)

14.
Weiss DJ. Drug-associated blood cell dyscrasias. Compend Contin Educ Vet 2012, 34, E2.

15.
Zaccara G, Franciotta D, Perucca E. Idiosyncratic adverse reactions to antiepileptic drugs. Epilepsia 2007, 48, 1223-1244. crossref(new window)