JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Hair growth promoting effects of emodin in telogenic C57BL/6 mice
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Hair growth promoting effects of emodin in telogenic C57BL/6 mice
Yon, Jung-Min; Park, Seul Gi; Lin, Chunmei; Gwon, Lee Wha; Lee, Jong-Geol; Baek, In-Jeoung; Lee, Beom Jun; Yun, Young Won; Nam, Sang-Yoon;
  PDF(new window)
 Abstract
Emodin is an anthraquinone derivative from the roots of Rheum officinale Baill that possesses a variety of biological activities, including inhibition of -reductase and prostaglandin D2. In this study, we investigated whether emodin promotes hair growth. After emodin was topically applied to the shaved dorsal skin of telogenic C57BL/6 N mice, the hair growth rate and morphological analysis were evaluated in dorsal skin for 15 days. After 13 days of treatment, minoxidil or emodin (0.01% or 0.1%)-treated groups showed remarkable regrowth of hairs relative to the vehicle control group. Scoring of the hair growth and rate of hair growth area for 15 days revealed that groups treated with minoxidil and 0.1% emodin were significantly higher than the vehicle control group. Histological examination revealed the emodin and minoxidil groups markedly recovered the number and morphology of hair follicles, including the subcutis depth, relative to the vehicle group. These results suggest that emodin has an excellent promoting effect in hair growth similar to that of minoxidil and might be useful for treatment of baldness or alopecia.
 Keywords
C57BL/6 mice;alopecia;emodin;hair growth;
 Language
English
 Cited by
 References
1.
Alonso L, Fuchs E. The hair cycle. J Cell Sci 2006, 119, 391-393. crossref(new window)

2.
Chellini PR, Pirmez R, Raso P, Sodre CT. Generalized hypertrichosis induced by topical minoxidil in an adult woman. Int J Trichology 2015, 7, 182-183. crossref(new window)

3.
Cho CH, Bae JS, Kim YU. 5alpha-reductase inhibitory components as antiandrogens from herbal medicine. J Acupunct Meridian Stud 2010, 3, 116-118. crossref(new window)

4.
Datta K, Singh AT, Mukherjee A, Bhat B, Ramesh B, Burman AC. Eclipta alba extract with potential for hair growth promoting activity. J Ethnopharmacol 2009, 124, 450-456. crossref(new window)

5.
Garza LA, Liu Y, Yang Z, Alagesan B, Lawson JA, Norberg SM, Loy DE, Zhao T, Blatt HB, Stanton DC, Carrasco L, Ahluwalia G, Fischer SM, FitzGerald GA, Cotsarelis G. Prostaglandin $D_2$ inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia. Sci Transl Med 2012, 4, 126ra34.

6.
Goren A, Shapiro J, Roberts J, McCoy J, Desai N, Zarrab Z, Pietrzak A, Lotti T. Clinical utility and validity of minoxidil response testing in androgenetic alopecia. Dermatol Ther 2015, 28, 13-16. crossref(new window)

7.
Hoffmann R, Happle R. Current understanding of androgenetic alopecia. Part I: etiopathogenesis. Eur J Dermatol 2000, 10, 319-327.

8.
Jain R, De-Eknamkul W. Potential targets in the discovery of new hair growth promoters for androgenic alopecia. Expert Opin Ther Targets 2014, 18, 787-806. crossref(new window)

9.
Lu Y, Yang JH, Li X, Hwangbo K, Hwang SL, Taketomi Y, Murakami M, Chang YC, Kim CH, Son JK, Chang HW. Emodin, a naturally occurring anthraquinone derivative, suppresses IgE-mediated anaphylactic reaction and mast cell activation. Biochem Pharmacol 2011, 82, 1700-1708. crossref(new window)

10.
Muller-Rover S, Handjiski B, van der Veen C, Eichmuller S, Foitzik K, McKay IA, Stenn KS, Paus R. A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages. J Invest Dermatol 2001, 117, 3-15. crossref(new window)

11.
Nieves A, Garza LA. Does prostaglandin $D_2$ hold the cure to male pattern baldness? Exp Dermatol 2014, 23, 224-227. crossref(new window)

12.
Oh JY, Park MA, Kim YC. Peppermint oil promotes hair growth without toxic signs. Toxicol Res 2014, 30, 297-304. crossref(new window)

13.
Paus R, Foitzik K. In search of the "hair cycle clock": a guided tour. Differentiation 2004, 72, 489-511. crossref(new window)

14.
Roberts J, Desai N, McCoy J, Goren A. Sulfotransferase activity in plucked hair follicles predicts response to topical minoxidil in the treatment of female androgenetic alopecia. Dermatol Ther 2014, 27, 252-254. crossref(new window)

15.
Rossi A, Cantisani C, Melis L, Iorio A, Scali E, Calvieri S. Minoxidil use in dermatology, side effects and recent patents. Recent Pat Inflamm Allergy Drug Discov 2012, 6, 130-136. crossref(new window)

16.
Shin HS, Lee JM, Park SY, Yang JE, Kim JH, Yi TH. Hair growth activity of crataegus pinnatifida on C57BL/6 mouse model. Phytother Res 2013, 27, 1352-1357. crossref(new window)

17.
Shrimali D, Shanmugam MK, Kumar AP, Zhang J, Tan BK, Ahn KS, Sethi G. Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer. Cancer Lett 2013, 341, 139-149. crossref(new window)

18.
Stenn KS, Paus R. Controls of hair follicle cycling. Physiol Rev 2001, 81, 449-494.

19.
Vasas A, Orban-Gyapai O, Hohmann J. The genus Rumex: review of traditional uses, phytochemistry and pharmacology. J Ethnopharmacol 2015, 175, 198-228. crossref(new window)

20.
Wei WT, Lin SZ, Liu DL, Wang ZH. The distinct mechanisms of the antitumor activity of emodin in different types of cancer (Review). Oncol Rep 2013, 30, 2555-2562.

21.
Yim E, Nole KL, Tosti A. $5{\alpha}$-reductase inhibitors in androgenetic alopecia. Curr Opin Endocrinol Diabetes Obes 2014, 21, 493-498. crossref(new window)

22.
Yon JM, Lin C, Oh KW, Baek HS, Lee BJ, Yun YW, Nam SY. Emodin prevents ethanol-induced developmental anomalies in cultured mouse fetus through multiple activities. Birth Defects Res B Dev Reprod Toxicol 2013, 98, 268-275. crossref(new window)