The automated chemical analysis shop floor are developed for the environmental pollution problems in our chemical analysis center. This shop floor have the several equipments include weight, pour, dry, heater, boiler, mixture, spectroscopy etc. And the material handling components are made up by the stored stack, conveyore, turntables, robot etc. Computer simulation has been an important tool for these complete design problem. We have designed the arangement of chemical equipments and material flow systems by using the simulator "AutoModII". "AutoMoII" is one of the advanced simulator, CAD-like drawing tools with a powerful, engineering oriented language to model control logic and material flow. The result is the modeling of the chemical analysis system in accurate, three dimensional detail. We could designed the set able layout and scheduling system by using the AutoMoII simulator. AutoMoII simulator.