The active vibration control of laminated composite shell has been performed with the optimized sensor/actuator system. PVDF film is used fur the material of sensor/actuator. Finite element method is utilized to model the whole structure including the piezoelectric sensor/actuator system, The distributed selective modal sensor/actuator system is established to prevent the adverse effect of spillover. In the finite element discretization process, the nine-node shell element with five nodal degrees of freedoms is used. Electrode patterns and lamination angles of sensor/actuator are optimized using genetic algorithm. Sensor is designed to minimize the observation spillover, and actuator is designed to minimize the system energy of the control modes under a given initial condition. Modal sensor/actuator profiles are optimized for the first and the second modes suppression of singly curved cantilevered composite shell structure. Discrete LQG method is used as a control law. The real time vibration control with profile optimized sensor/actuator system has been performed. Experimental result shows successful performance of the integrated structure for the active vibration control.