Neuroprotective effect of Hexane fraction of A0054 on Delayed Neuronal Death after Transient global Ischemia in Gerbil Hippocampus

  • Kim, Haw-Jung (Natural Products Research Institute, College of Pharmacy, Seoul National University) ;
  • Lee, Sung-Jin (Natural Products Research Institute, College of Pharmacy, Seoul National Universit) ;
  • Je, Kang-Hoon (Natural Products Research Institute, College of Pharmacy, Seoul National Universit) ;
  • Mar, Woong-Chon (Natural Products Research Institute, College of Pharmacy, Seoul National University)
  • Published : 2003.04.01

Abstract

Several lines of recent evidences have shown that several pro-inflammatory genes or mediators, such as inducible nitric oxide synthase (iNOS), cyclooxygenase-2 and cytokines (e.g., tumor necrosis factor $\alpha$ and interleukin-1$\beta$), are strongly expressed in the ischemic brain. Inflammation is now recognized as a significant contributing mechanism in cerebral ischemia because anti-inflammatory compounds or inhibitors of iNOS and cyclooxygenase-2 have been proven to reduce ischemic brain damage. (omitted)

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