Radio Iodination of Organic Compounds (1) A Low Temperature Procedures

放射性 沃化反應 (第 1 報) 低溫沃化反應

  • YOU SUN KIM (Chemistry Division, Atomic Energy Research Institute) ;
  • CHONG DOO KIM (Chemistry Division, Atomic Energy Research Institute)
  • 김유선 (原子力硏究所 化學硏究室) ;
  • 김종두 (原子力硏究所 化學硏究室)
  • Published : 19670600

Abstract

A procedure, which is effective enough to label various compounds at low temperature by radioactive iodine, was investigated. The chloramine-T procedure was mostly effective for labelling various protein, amino acids, hormones, and organic compounds by iodine, and the procedure was able to afford both high specific activity and high radiochemical yield. However, the procedure was ineffective for labelling unsaturated compounds or other organic compounds which has not active aromatic nucleus of reactive character. The radiochemical yield of the procedure was generally averaged from 100% to 60%. The reactivity of the aromatic part of the organic compound towards this reagent was correspond to that of an electrophillic reagent. The procedures were described and the reaction path was considered.

Keywords

References

  1. Private Communication Nov. G. Gleason
  2. Medical Symposium No. 9 R. S. Yallow;W. M. Hunter
  3. Proceeding of the Symposiun on Nuclear Medicine
  4. Journal of NuCl. Sci. Y. S. Kim
  5. Private Communication Y. S. Kim
  6. Ber v.19 Kikodo
  7. Handbook of Organic Chemistry Kikodo
  8. Advaned Org. Chem. Fieser & Fieser