Radio iodination (II) Radio iodination of various aromatic derivatives in organic solvent at low temperature

放射性 요오드化 反應 (第 II 報) 有機容媒 中에서의 各種 芳香誘導體의 低溫 요오드化 反應

  • Kim, You-Sun (Chemistry Division, Atomic Energy Research Institute) ;
  • Kim, Chong-Doo (Chemistry Division, Atomic Energy Research Institute)
  • 김유선 ($原子力硏究所{\cdto}化學硏究室 $) ;
  • 김종두 ($原子力硏究所{\cdto}化學硏究室 $)
  • Published : 19680300

Abstract

Radio iodination of various aromatic derivatives (aniline, toluene, iodobenzene, acetanilide, benzene, benzoic acid) were achieved at low temperature by a chloroamine-T procedures in presence of polar solvent(dioxane). Organic base (piperidine) was used as the catalyst. Iodine replacement reaction had occured on the aromatic or alicyclic ring by this reaction, and the kind and ratio of iodinated products were proved to be different from those of usual iodide reaction in organic solvent at low temperature. The reactivity of various aromatic or alicyclic compounds towards the present iodination system was evaluated and the scope and limitation of the present procedures in the preparation of radio pharmaceuticals were discussed.

Keywords

References

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