Synthesis of DL-1-Amino Alkyl Phosphonic Acids and their Derivatives

DL-1-Aminoalkyl Phosphonic Acids와 그유도체들의 합성 (I)

  • Cho Kyung Yeon (Department of Chemical Engineering, College of Science and Engineering Korea University) ;
  • Kim Duck Chan (Department of Chemical Engineering, College of Science and Engineering Korea University) ;
  • Kim Yong Joon (Department of Chemical Engineering, College of Science and Engineering Korea University)
  • Published : 19710230

Abstract

DL-1-Amino-pentyl phosphonic acid, DL-1-Aminopropyl phosphonic acid were synthesized with good yield from caproic acid and butyric acid using the modified Curtius reaction and N-derivatives, N-acetyl-DL-1-amino propyl phosphonic acid, N-acetyl-DL-1-aminopentyl phosphonic acid, N-Benzoyl-DL-1-amino-propyl phosphonic acid, were also prepared by a variety of methods including the Schotten-Baumann reaction. In addition, the chemical and physical properties of the products were investigated. All the products were also identified by means of elemental analysis, Infrared spectrophotometry, Ninhydrin test, and the determination of the neuralization equivalent.

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