Studies on Hydroxyamine Derivatives of 2,2'-Methylene bis(3,4,6-trichloroacetoxy benzene)

2,2'-Methylene bis(3,4,6-trichloroacetoxy benzene)의 Hydroxyamine유도체에 관한 연구

  • Yu, Ju-Hyun (Department of Food Engineering, Yonsei University) ;
  • Kim, Jong-Ho (Department of Chemistry, Kyung Hee University) ;
  • Lee, Suk-Young (Department of Agricultural Chemistry, Chunpuk National University)
  • Published : 1972.06.28


Seven new hydroxyamine derivatives of 2,2'-methylene bis(3,4,6-trichloroacetoxy benzene) were synthesized by the Mannich reactions. 13 strains of microorganisms were tested for sensitivity to these derivatives by both paper disk method and tube dilution method. Of these compounds, -NHOH compound displays the most effective antimicrobial activity in vitro against Brevibacterium ammoniagenes, Staphylococcus aureus and Bacillus subtilis. Its minimal inhibitory concentration is $1.6{\mu}g/ml$ for Brevibacterium ammoniagenes, and $5{\mu}g/ml$ for Staphylococcus aureus and Bacillus subtilis.