Hematological Studies in Reference to Immune Enhancement Mechanism of Formalin Applied to Formalin Inactivated Anthrax Vaccines in Rabbits

Formalin 처리(處理) 면역원(免疫原)에 대한 가토(家兎)의 혈액세포상(血液細胞像)에 관한 연구

  • Jeon, Yun Seong (College of Veterinary Medicine, Seoul National University) ;
  • Choi, Hi In (College of Veterinary Medicine, Seoul National University)
  • 전윤성 (서울대학교 수의과대학) ;
  • 최희인 (서울대학교 수의과대학)
  • Published : 1976.05.30


Hematological studies were conducted in reference to the immune enhancing mechanism of formalin applied to, as an inactivating agent, a formalin inactivaed anthrax vaccines in rabbits. Rabbits were inoculated two types of formalinized anthrax immunogens namely capsular and spore vaccines in addition of formalin saline as a control. From immune rabbits, peripheral blood was collected and subjected to count a total erythrocytes, leukocytes, and pyroninophilic lymphocytes. The experimental results were summarized as followings. At a level of 0.5M 0.5ml formalin with or without the addition to vaccine, a total leukocytes count was increased. Due to the increased lymphocytes, the ratio of neutrophil and lymphocyte was lowered within 4 to 12 hours of the postinoculation. Formalin saline, anthrax spore vaccine and capsular vaccine, without group difference, caused an increased level of pyroninophilic lymphocytes in peripheral blood. Throughout the studies, a possible role of immune enhancement by formlin was disscused and suggested.