Protection Mechanism of Infection Against Tyzzer's Disease

마우스에 있어서의 Tyzzer병(病) 감염방어기구(感染防禦機構)

  • Lee, Yong Soon (College of Veterinary Medicine, Seoul National University) ;
  • Lee, Jang Nak (College of Veterinary Medicine, Seoul National University)
  • Published : 1980.07.30


1. In adult ICR-SLC mice, significant increase in the occurrence of the Tyzzer's disease was noted when the reticuloendothelial system was blockaded with the carbon particles. The most suitable bloakading time was 2 hours before inoculating Tyzzer's organisms, the route was intraperitoneal and the dose was 3mg/body. 2. Survival rate of the experimental group ICR-SLC suckling mice receiving BCG ($3{\times}10^8$) 6 days prior to intraperitoneal inoculation of Tyzzer's organisms was 80 percent, but the control group was 17%. 3. In comparing the survival rate of the nude/nude mice with the nude/+ mice, the former congenitally thymus deficient mice are 11 percent, but the latter are 67 percent.