Synthesis of 2,4-Dienoic Acid Derivatives by Palladium Catalyzed Homogeneous Reaction

팔라듐 촉매 균일계 반응을 이용한 2,4-디엔산 유도체의 합성

  • Jin Il Kim (Department of Industrial Chemistry, Han Yang University)
  • 김진일 (한양대학교 공업화학과)
  • Published : 1983.12.20


A wide variety of vinylic bromides such as (Z)-1-bromopropene, 1-bromo-2-methylpropene, 2-bromo-3-methyl-2-butene, (E)-ethyl 2-methyl-3-bromo-2-propenoate, 1-bromo-cyclohexene has been found to react with ethyl acrylate, ethyl 3-butenoate, allyl cyanide, (E)-ethyl crotonate, ethyl 4-pentenoate, methyl 10-undecenoate and methyl methacrylate in the presence of triethylamine and a palladium acetate-triorthotolylphosphine catalyst. In general, 2,4-dienoic acid derivatives were obtained in good yield and stereochemistry of the products was determined. Using this method, four, five and eleven carbon-carbon extension with ethyl 3-butenoate, ethyl 4-pentenoate and methyl 10-undecenoate was also possible.



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