Synthesis and Antimicrobial Properties of Surfactants Contaning Phenazine Ring (Ⅱ)

Phenazine Ring을 가진 界面活性劑의 合成과 그 抗菌性 (제2보)

  • Jong Dae Kim (Department of Chemistry, Yeungnam University) ;
  • Dong Soo Kim (Department of Chemistry, Yeungnam University) ;
  • Sang Jik Lee (Department of Chemistry, Yeungnam University) ;
  • Sung Wook Han (Department of Chemistry, Yeungnam University)
  • 김종대 (영남대학교 이과대학 화학과) ;
  • 김동수 (영남대학교 이과대학 화학과) ;
  • 이상직 (영남대학교 이과대학 화학과) ;
  • 한성욱 (영남대학교 이과대학 화학과)
  • Published : 1983.12.20


-Alkyl-2-hydroxyphenazine-5,10-dioxides were synthesized from hydroquinone, and alkyl benzofuroxanes which were previously obtained through five reaction steps starting from aniline. Infrared, nuclear mangnetic resonance spectrometry and elemental analysis were employed to identify the products concerned in the synthetic processes. It was observed that these alkylated phenazine oxides lowered the surface tension of water substantially. These derivatives showed stronger antimicrobial activity against both gram positive and negative microbes than 1-carboxyphenazine which had no alkyl side chain. It was also found that the antimicrobial activity of the phenazine compound increased when the nitrogen of the ring was bound to the oxygen atom.



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