A New Route to Diethyl 3,4,5-Trimethoxybenzylmalonate, a Trimethoprim Intermediate

Trimethoprim 중간체인 Diethyl 3,4,5-Trimethoxybenzylmalonate의 새로운 합성

  • 정봉영 (고려대학교 이과대학 화학과) ;
  • 이채호 (고려대학교 이과대학 화학과)
  • Published : 1985.10.20

Abstract

Direct condensation of 3,4,5-trimethoxybenzoyl chloride with diethyl malonate followed by chlorination and hydrogenolysis afforded diethyl 3,4,5-trimethoxybenzylmalonate in 70% overall yield.

Keywords

References

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