Effect of Diallyl Disulfide on the Hepatic Glutathione S-Transferase Activity in Rat : Diallyl Disulfide Effect on the Glutathione S-Transferase

  • Huh, Keun (Dept. of Pharmacology, College of Pharmacy, Yeungnam University) ;
  • Lee, Sang-Il (Dept. of Pharmacology, College of Pharmacy, Yeungnam University) ;
  • Park, Jong-Min (Dept. of Pharmacology, College of Pharmacy, Yeungnam University) ;
  • Kim, Seok-Hwan (Dept. of Food and Nutrition, Dong-A University)
  • Published : 1986.12.01

Abstract

Glutathione s-transferase in thought to play a key role in initiating the detoxication of potential alkylating agents, including pharmacologically active compounds. It is widely accepted that garlic contained allin which is converted to allicin by allinase. Allicin is easily degraded to diallyl disulfide and other components. This report attempted to observe the effect of diallyl disulfide on some biological activities. It was observed that the activity of serum transaminase was not changed by the treatment of diallyl disulfide. The liver cytosolic glutathione s-transferase was significantly increased. where as the microsomal glutathione s-transferase was not increased.