Synthesis and Antimicrobial Properties of Surfactants Containing Phenazine Ring (III)

Phenazine Ring을 가진 界面活性劑의 合成과 그 抗菌性 (제3보)

  • Jong Dae Kim (Department of Chemistry, Teungnam University) ;
  • Ho Sik Kim (Department of Chemistry, Teacher's College, Hyosung Women's University) ;
  • Sung Wook Han (Department of Chemistry, Teungnam University)
  • 김종대 (영남대학교 이과대학 화학과) ;
  • 금호식 (효성여자대학교 사범대학 화학과) ;
  • 한성욱 (영남대학교 이과대학 화학과)
  • Published : 1986.02.20


7-Alkyl-2-aminophenazine-5,10-dioxides bearing butyl, hexyl and octyl group were synthesized by the reaction of 4-aminophenol with 6-alkylbenzofuroxans which had been obtained from aniline and n-alkyl alcohols. And 2-aminophenazine-5,10-dioxide was prepared by the reaction of 4-aminophenol with benzofuroxan. Infrared, nuclear magnetic resonance spectrophotometers, and elemental analyzer were employed to identify the products concerned with the synthetic processes. Surface tension of aqueous solutions of these phenazine derivatives was determined by surface tensiometer and it was found that the surface tension decreased with an increase of the number of carbon in the alkyl group. Antimicrobial activities were evaluated in terms of minimum inhibitory concentration by a dilution method. The butyl derivative showed the highest activity among these derivatives. It was observed that the antimicrobial activity of these alkyl substituted 2-aminophenazine-5,10-dioxides was stronger than that of 2-aminophenazine-5,10-dioxide.



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