Effects of Propylthiouracil and Thyroxine on Thyroid Function and Body Growth in Rats

Propylthiouracil 및 Thyroxine의 처리(處理)가 흰쥐의 갑상선기능(甲狀腺機能)과 체성장(體成長)에 미치는 영향(影響)

  • Seo, Kil Woong (Dept. of Dairy Science, Coll. of Agriculture, Chungnam Nat'l Univ.) ;
  • Lee, Kyu Seung (Dept. of Animal Science, Coll. of Agriculture, Chungnam Nat'l Univ.) ;
  • Park, Chang Sik (Dept. of Animal Science, Coll. of Agriculture, Chungnam Nat'l Univ.)
  • 서길웅 (충남대학교 농과대학 낙농학과) ;
  • 이규승 (충남대학교 농과대학 축산학과) ;
  • 박창식 (충남대학교 농과대학 축산학과)
  • Published : 1986.12.31


This study was conducted to find out the effects of propylthiouracil and thyroxine on thyroid function and body growth in female rats. One hundred and forty-four female rats (Wistar-imamichi albino rats) of 25 days old were divided into 4 groups; thyroidectomy (Thx), propylthiouracil (PTU), thyroxine (Thyro.)and control (Cont.) groups. Thirty-six rats were allotted to each group, and changes of body weights were weekly checked. In addition, 6 rats in each group were sacrificed at 1, 2, 3, 5 and 6 weeks after treatments with time elapse for investigating changes of thyroid weights and tissues. The results obtained were as follows: 1. The weights of thyroid gland showed significant differences among all the compared groups at all observation times. The weights of thyroid glands in PTU group were higher than those in control group, but those in the Thyro. group were lower than those in control group. 2. In the histological changes of thyroid glands in the PTU group, the follicle epithelium showed columnar cells following hype trophy and hyperplasia from 1 week after treatment. The follicle epithelium in the Thyro. group were recognized inactive showing squamous cells. 3. The body weights showed significant differences among the compared groups from 2 weeks after treatment. The body weights decreased significantly in PTU and Thx. groups, while those in Thyro. group increased significantly in comparison with those in control group. No significant difference in body weight was noted between PTU and Thx. groups.