Mutagenicities of Carbonyl Compounds Derived from Maillard Reaction and their Desmutagenicity Mechanisms

Maillard 반응 유래(由來) 저분자 카르보닐화합물의 돌연변이원성과 그 억제기구

  • Kim, Seon-Bong (Department of Food Science and Technology, National Fisheries University of Pusan) ;
  • Yeom, Dong-Min (Department of Food Science and Technology, National Fisheries University of Pusan) ;
  • Do, Jeong-Ryong (Department of Food Science and Technology, National Fisheries University of Pusan) ;
  • Yoon, Hyeung-Sik (Department of Food Science and Technology, National Fisheries University of Pusan) ;
  • Byun, Han-Seok (Department of Food Science and Technology, National Fisheries University of Pusan) ;
  • Kim, In-Soo (Department of Food Nutrition and Science, National Tong-Yeong Fisheries Technical College) ;
  • Park, Yeung-Ho (Department of Food Science and Technology, National Fisheries University of Pusan)
  • 김선봉 (부산수산대학 식품공학과) ;
  • 염동민 (부산수산대학 식품공학과) ;
  • 도정룡 (부산수산대학 식품공학과) ;
  • 윤형식 (부산수산대학 식품공학과) ;
  • 변한석 (부산수산대학 식품공학과) ;
  • 김인수 (통영수산전문대학 식품영양학과) ;
  • 박영호 (부산수산대학 식품공학과)
  • Published : 1989.06.01

Abstract

The present study was attempted to investigate the mutagenicities of carbonyl compounds(methyl glyoxal, glyoxal, diacetyl, dihydroxyacetone, glycolaldehyde, glyceraldehyde and furfural) derived from Maillard reaction toward Salmonella typhimurium TA 100(base-substitution mutant) without metabolic activation . And for further Investigation of mutagenicity mechanism including desmutagenicity, active oxygen scavengers (cysteine, ${\alpha}-tocopherol$, tris (hydroxymethyl) aminomethane, catalase, ascorbic acid) and reducing agents (glutathione, sodium bisulfite) were also used. Among carbonyl compounds tested, methyl glyoxal, glyoxal, dihydroxyacetone, glycolaldehyde and glyceraldehyde exhibited mutagenicities, and methyl glyoxal showed the strongest mutagenic activity. On the other hand , the mutagenicities of carbonyl compounds were significantly suppressed by cysteine, tris (hydroxymethyl) aminomethane, glutathione and sodium bisulfite. Also, these active oxygen scavengers and reducing agents alone did not show mutagenicity in the present study.

Keywords

mutagenicity;desmutagenicity;carbonyl compounds