Effects of Evening Primrose Oil on Plasma Cholesterol and Fatty Acid Compositions of Erythrocyte Membrane and Aorta in Rats

달맞이꽃 종자유의 섭취가 흰쥐의 혈장 콜레스테롤과 적혈구막 및 대동맥의 지방산조성에 미치는 영향

  • Choi, Im-Soon (Department of Food & Nutrition, Dongduck Women's University)
  • 최임순 (동덕여자대학교 식품영양학과)
  • Published : 1989.12.01


Weanling male Sprague-Dawley rats were divided into 4 groups according to the level of plasma cholesterol and then fed diets containing 15%(w/w) corn oil, lard or evening primrose oil (EPO) with 0.5% (w/w) of cholesterol. Corn oil without cholesterol was used as a dietary lipid source of control diet. After 4 weeks of feeding, the fatty acid compositions of the red blood cell membrane and aorta phospholipids were analyzed together with the plasma cholesterol level. The rats fed with EPO characterized by its content of gamma-linolenic acid (GLA) showed lower cholesterol concentration in plasma than the other groups . In the corn oil groups, plasma cholesterol level was not affected by the addition of dietary cholesterol. The concentrations of dihomogamma-linolenic acid and arachidonic acid, metabolites of GLA, in the tissue were increased in the EPO group compared with the other groups.


evening primrose oil;gamma-linolenic acid;plasma cholesterol;tissue fatty acid composition