Effect of Alfalfa Saponin on the Serum Cholesterol Level in Rats

알팔파 사포닌이 흰쥐 혈청 콜레스테롤 농도에 미치는 영향

  • Cho, Young-Su (The Graduate School of Natural Science and Technology, Okayama University) ;
  • Horigome, Takao (The Graduate School of Natural Science and Technology, Okayama University)
  • 조영수 (강산대학 대학원 자연과학연구과) ;
  • 굴미강남 (강산대학 대학원 자연과학연구과)
  • Published : 1989.12.30

Abstract

Alfalfa saponin was isolated from the roots of alfalfa(Medicage sativa L.) and incoporated at the level of 0.2% and 0.4% cholesterol-free diets and cholesterol enriched-diets. Wistar male rats weighing approximately 80g were fed with for 21 days. The serum lipids and fecal excretion lipids of the rats were determined and the result obtained are as follows. 1. Alfalfa saponin contained 36.4% medicagenic acid. 2. The feeding of alfalfa saponin increased cholesterol excretion but not bile acid excretion. 3. Alfalfa saponin showed hypocholesterolemic activity at 0.4% level in both the diets with and without cholesterol but the effect was not observed at 0.2% level in a diet. 4. It was indicated that the hypocholesterolemic effect of alfalfa saponin was associated with the decreased absorption of cholesterol from alimentary canal.

Keywords