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EFFECTS OF CHRONIC INGESTION OF ANTHRANILIC ACID ON LACTATION IN MICE

  • Nagasawa, H. (Animal Breeding and Experimental Animal Research Laboratory, Meiji University) ;
  • Suzuki, M. (Animal Breeding and Experimental Animal Research Laboratory, Meiji University) ;
  • Sakagami, N. (Animal Breeding and Experimental Animal Research Laboratory, Meiji University) ;
  • Inatomi, H. (Laboratory of Natural Product Chemistry, Meiji University) ;
  • Yamamoto, K. (Department of Biology, School of Education, Waseda University)
  • Received : 1988.11.10
  • Accepted : 1989.02.07
  • Published : 1989.03.01

Abstract

Treatment of mice with 0.04% anthranilic acid (AnA) as drinking water resulted in an apparent stimulation of pup's growth and food intake of mothers in their first lactations associated with an increased rearing rate and no alteration in plasma prolactin level. AnA showed no significant effects on the day of vaginal opening, the pattern of estrous cycles, plasma growth hormone level and endocrine organ weights of the female and male offspring. The growth of male offspring was significantly retarded by AnA, however, their reproductivity was quite normal. The results indicate the AnA can simulate lactation of mice through little modulation of endocrine systems.

Keywords

Anthranilic Acid;Body Growth;Food Intake;Lactation;Mouse