Effect of yohimbine and 4-aminopyridine on gastroduodenal transit time in xylazine-pentobarbital-anesthetized dogs

Xylazine과 pentobarbital로 마취한 개에서 yohimbine과 4-aminopyridine투여가 위십이지장 통과 시간에 미치는 영향

  • Kim, Dong-jun (College of Veterinary Medicine, Seoul National University) ;
  • Choi, Min-chul (College of Veterinary Medicine, Seoul National University) ;
  • Sung, Jai-ki (College of Veterinary Medicine, Seoul National University)
  • 김동준 (서울대학교 수의과대학) ;
  • 최민철 (서울대학교 수의과대학) ;
  • 성재기 (서울대학교 수의과대학)
  • Received : 1989.12.30
  • Published : 1990.01.31

Abstract

The present study was undertaken to determine the effect of xylazine-pentobarbital anesthesia on the gastroduodenal transit time of barium sulfate and whether this condition can be antagonized by yohimbine, 4-aminopyridine and yohimbine+4-aminopyridine in dogs. Xylazine-pentobarbital anesthesia prolonged the gastroduodenal transit time to $121.50{\pm}21.25$ minutes compared with $5.25{\pm}0.90$ minutes of control. Yohimbine and yohimbine+4-aminopyridine reversed $121.50{\pm}21.25$ minutes of transit time of anesthetized dog to $25.25{\pm}6.83$ and $63.25{\pm}15.69$ minutes, respectively. 4-aminopyridine alone, $115.75{\pm}$18.35 minutes, was not effective in reversing the xylazine-pentobarbital-induced prolongation of gastroduodenal transit time. Yohimbine was the most effective for reversal of xylazine-pentobarbital-induced prolongation of gastroduodenal transit time in dogs.