Antagonism of xylazine-induced hypotensive effect by yohimbine in rabbits

가토(家兎)에서 xylazine의 혈압하강(血壓下降) 효과(效果)에 대한 yohimbine의 길항작용(拮抗作用)

  • Shin, Dong-ho (College of Veterinary Medicine, Chonnam National University)
  • 신동호 (전남대학교 수의과대학)
  • Received : 1990.04.12
  • Published : 1990.07.31

Abstract

Xylazine is commonly used for anesthesia in veterinary medicine and various adverse effects are developed. To examine if the severe hypotensive response associated with xylazine-induced anesthesia might be resulted from the stimulation of presynaptic alpha-2 adrenoceptors or the increase of vagal tone, effects of yohimbine, atropine and atropine with vagotomy on xylazine-induced severe and long-lasting hypotensive responses were investigated in rabbits. The results were summarized as follows: 1) Intravenously injected xylazine(1mg/kg)-induced hypotensive responses were inhibited by yohimbine(p<0.001). 2) Intravenously injected xylazine(1mg/kg)-induced hypotensive responses were not changed by atropine. 3) Intravenously administered xylazine(1mg/kg)-induced hypotensive responses are not changed by atropine with vagotomy. These results indicate that xylazine is thought to cause severe hypotensive response during anesthesia primarily by stimulating presynaptic alpha-2 adrenoceptors and other receptors or mechanisms may participate in the hgpotensive response of xylazine.