Effect of nifedipine against carrageenan-induced paw oedema in rats

흰쥐에서 carrageenan에 의한 족부종(足浮腫)에 대한 nifedipine의 영향

  • Shin, Dong-ho (College of Veterinary Medicine, Chonnam National University)
  • 신동호 (전남대학교 수의과대학)
  • Received : 1990.05.13
  • Published : 1990.07.31


The effects of nifedipne and verapamil were compared on carrageenan-induced paw edema in rats and the results are summarized as follows: Carrageenan induced severe acute paw edema within 30 minutes and the maximum effect was achieved around 4 hours after administration. The carrageenan-induced paw edema was prominantly reduced by pretreatments of indomethacin (2mg/kg, p.o.) and nifedipine (10 and 20mg/kg, i.p.), whereas verapamil had no effect on the carrageenan-induced paw edema. These results suggest that calcium antagonists, nifedipine and verapamil, have a different effect on the inflammatory response induced by carrageenan.