Antitumor Effect of Polysaccharide Produced from a Mutant of Acetobacter pasteurianus IFO 13751-5

Acetobacter pasteurianus IFO 13751-5 변이주가 생산하는 다당류의 항암효과

  • Kim, Dong-Seuk (Department of Food Science and Technology, Kyungsung University) ;
  • Ryu, Beung-Ho (Department of Food Science and Technology, Kyungsung University)
  • 김동석 (경성대학교 공과대학 식품공학과) ;
  • 류병호 (경성대학교 공과대학 식품공학과)
  • Published : 1991.08.01

Abstract

The polysaccharide was predominantly composed of glucose (79.60%), galactose (9.68%), mannose(8.67%), fructose (1.96%;) and xylose (0.09%). Major amino acid in protein was consisted of cystein, aspartic acid, valine and glutamic acid. The tumor growth inhibition ratio of the polysaccharide against Sarcoma 180 was at highest level of 64.96%, when administerd at the concentration of 50 mg/kg and life prologation ratio showed 28.91% at the concentration of 50 mg/kg. The direct cytotoxic effect of polysaccharide was not observed in the tumor bearing mice with Sarcoma 180 in vitro.

Keywords

tumor growth inhibition ratio;life prolongation;direct cytotoxic effect