Attempts to Transfer Immunity against Clonorchis in Nude and DS Mice

근교계 nude 및 DS 마우스 폐강삼출세포와 혈청의 간흡충 감염에 대한 면역이입의 시도

  • Choe, Dong-Ik (Department of Parasitology, Kyungook National University School of Medicine) ;
  • Jeong, Dong-Il (Department of Parasitology, Kyungook National University School of Medicine) ;
  • Gang, Deok-Hui (Department of Parasitology, Kyungook National University School of Medicine)
  • 최동익 (경북대학교 의과대학 기생충학교실) ;
  • 정동일 (경북대학교 의과대학 기생충학교실) ;
  • 강덕희 (경북대학교 의과대학 기생충학교실)
  • Published : 1991.12.01

Abstract

The effects of peritoneal exudate cells(PEC) and sera of athymic nude and DS mice infected with Clonorchis sinensis metacercariae or sensitized by injection of metabolic products into footpad on transfer of immunity against the fluke to the syngeneic mice were studied. There was no significant difference in eggs per gram pattern between the sensitized and control groups, and between nude and DS mice. However, the worm burdens were slightly greater in nude mice than in DS mice. Also, a few plaque forming cells were found in only DS mice given PEC and serum from Group II DS mice. In the light of these results, it is likely that PEC and sera of nude or DS mice which are deficient, at least partially, in the cellular immune system are unable to transfer immunity against C. sinensis to syngeneic recipients.